锂离子电池的多状态模型剩余寿命预测方法

针对锂离子电池的容量恢复现象导致的剩余寿命预测精度不高的问题,提出了一种锂离子电池的多状态模型剩余寿命预测方法.首先通过分析锂电池的衰退数据将锂离子电池的退化过程分为正常退化、容量恢复和加速退化三种状态,然后分别对三种状态的退化过程进行建模并验证了模型的有效性,将3种状态的模型组合得到锂离子电池多状态容量衰退模型.然后...     

Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration

RNA exosomes are multi-subunit complexes conserved throughout evolution and are emerging as the major cellular machinery for processing, surveillance and turnover of a diverse spectrum of coding and noncoding RNA substrates essential for viability. By exome sequencing, we discovered recessive mutations in EXOSC3 (encoding exosome component 3) in four siblings with infantile spinal motor neuron disease, cerebellar atrophy, progressive microcephaly and profound global developmental delay, consistent with pontocerebellar hypoplasia type 1 (PCH1; MIM 607596). We identified mutations in EXOSC3 in an additional 8 of 12 families with PCH1. Morpholino knockdown of exosc3 in zebrafish embryos caused embryonic maldevelopment, resulting in small brain size and poor motility, reminiscent of human clinical features, and these defects were largely rescued by co-injection with wild-type but not mutant exosc3 mRNA. These findings represent the first example of an RNA exosome core component gene that is responsible for a human disease and further implicate dysregulation of RNA processing in cerebellar and spinal motor neuron maldevelopment and degeneration.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

DPSIR model-based evaluation index system for geographic national conditions

Establishing a reasonable evaluation index system is the basis and premise for the scientific evaluation of geographic national conditions. By analyzing the DPSIR model and its correlation and relation with the evaluation index system, the indexes for geographic national conditions were selected from the aspects of resources, ecology, environment, economy, society, etc to build an evaluation index system for geographic national conditions that consists of three hierarchies: index, criterion, and target levels. Furthermore, the index system was analyzed in terms of index integrity, low overlapping of elements, non-existence of isolated indexes, hierarchy of index system, etc., for the purpose of demonstrating that the DPSIR model-based evaluation index system for geographic national conditions meets the principles of index system establishment.     

关于关系型与面向对象型数据库管理系统的争论

本文介绍了关系型数据库管理系统(RDBMS)与面向对象数据库管理系统(OODBMS)的技术,详细评述了人们围绕这两种技术展开的争论。     

剪切闸板防喷器剪切性能评价

剪切闸板防喷器是井控设备的重要组成部分之一,其作用是在钻井过程中遇到突发情况时及时剪断钻杆并密封井口,其剪切性能直接关系到钻井作业的安全.以某新型上直下V结构的剪切闸板防喷器为研究对象,通过显示动力学模块对剪切闸板剪切钻杆的过程进行数值仿真模拟,分析研究闸板的剪切性能.并用该剪切闸板分别剪切5 in和5.5 in两种不...     

基于改进隶属云模型蚁群算法的喷涂机器人喷枪轨迹组合优化

摘要： 针对复杂曲面分片后的喷枪轨迹组合优化问题,利用哈密尔顿图将其转化为广义开环旅行商问题(OTSP),采用“问题无关的进化算法与问题相关的局部搜索相结合”的策略,首先引入隶属云模型来自适应调节蚁群算法中控制的随机性,然后引入K-opt局部搜索策略的基于改进隶属云模型蚁群算法(MCMACA)对喷枪轨迹组合优化的OTSP问题进行求解.仿真结果表明,改进隶属云模型蚁群算法的全局搜索性和局部收敛性更佳,在复杂曲面上对喷涂机器人喷枪轨迹进行优化具有明显的优越性.
关键词： 组中图分类号：文献标志码： A     

碳酸氢盐碱度对低温厌氧消化及微生物群落的影响

15℃条件下,通过投加不同浓度碳酸氢钠来控制厌氧体系的碱度,采用间歇实验进行厌氧消化研究。结果显示,碳酸氢钠投加量为0.10mol/L时,体系能维持厌氧微生物适宜生长的pH值,48h内COD去除率达到75.43%。继续增大投加量,COD去除率没有明显升高;随着碳酸氢盐碱度的增加,VFA浓度峰值升高,但积累的VFA降解速度减慢;高浓度的碳酸氢盐碱度可以缩短产甲烷的滞后时间,但最终累积甲烷产量受其影响较小;碳酸氢盐碱度的适量投加可促进低温厌氧消化过程中微生物的生长代谢,提高微生物群落的丰富度以及多样性。     

A theoretical model for mid- and low-latitude ionospheric electric fields in realistic geomagnetic fields

The geomagnetic fields, which play important roles in the ionospheric dynamo, can greatly affect the global distribution of ionospheric electric fields, currents and other ionospheric electrodynamics phenomena. In the study of ionospheric electrodynamics phenomena, such as the longitudinal variations of ionospheric electric fields, the non-dipolar component of the geomagnetic fields must be taken into account. In this paper, we deduce a theoretical electric field model for ionospheric dynamo at mid- and low-latitude which adopt a modified magnetic apex coordinates system. In the new electric field model, the geomagnetic fields can be calculated from either the IGRF model or the dipole field model, and the neutral winds and conductivities are calculated based on empirical models. Then the dynamo equation for the electric potential is finally solved in terms of the line-by-line iteration method, and the ionospheric electric fields and currents are derived from the calculated potential. Our model can reproduce the main features of the ionospheric electrodynamics processes, so it will be a useful tool for the investigation of the upper atmosphere and ionosphere.