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231.
Asymmetry has been well documented in the business cycle literature. The asymmetric business cycle suggests that major macroeconomic series, such as a country's unemployment rate, are non‐linear and, therefore, the use of linear models to explain their behaviour and forecast their future values may not be appropriate. Many researchers have focused on providing evidence for the non‐linearity in the unemployment series. Only recently have there been some developments in applying non‐linear models to estimate and forecast unemployment rates. A major concern of non‐linear modelling is the model specification problem; it is very hard to test all possible non‐linear specifications, and to select the most appropriate specification for a particular model. Artificial neural network (ANN) models provide a solution to the difficulty of forecasting unemployment over the asymmetric business cycle. ANN models are non‐linear, do not rely upon the classical regression assumptions, are capable of learning the structure of all kinds of patterns in a data set with a specified degree of accuracy, and can then use this structure to forecast future values of the data. In this paper, we apply two ANN models, a back‐propagation model and a generalized regression neural network model to estimate and forecast post‐war aggregate unemployment rates in the USA, Canada, UK, France and Japan. We compare the out‐of‐sample forecast results obtained by the ANN models with those obtained by several linear and non‐linear times series models currently used in the literature. It is shown that the artificial neural network models are able to forecast the unemployment series as well as, and in some cases better than, the other univariate econometrics time series models in our test. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
232.
Weir BA Woo MS Getz G Perner S Ding L Beroukhim R Lin WM Province MA Kraja A Johnson LA Shah K Sato M Thomas RK Barletta JA Borecki IB Broderick S Chang AC Chiang DY Chirieac LR Cho J Fujii Y Gazdar AF Giordano T Greulich H Hanna M Johnson BE Kris MG Lash A Lin L Lindeman N Mardis ER McPherson JD Minna JD Morgan MB Nadel M Orringer MB Osborne JR Ozenberger B Ramos AH Robinson J Roth JA Rusch V Sasaki H Shepherd F Sougnez C Spitz MR Tsao MS Twomey D Verhaak RG Weinstock GM Wheeler DA Winckler W 《Nature》2007,450(7171):893-898
233.
The question of the existence of intelligent life on other worlds has never been a purely scientific one. Philosophical, religious and literary issues have been intertwined with scientific ones throughout the history of the “plurality of worlds” debate. This collection of papers in –Studies in History and Philosophy of Science– explores the interrelation of science, philosophy, religion and literature in debates about extraterrestrial life. 相似文献
234.
Jacob A. Bikker Laura Spierdijk Roy P. M. M. Hoevenaars Pieter Jelle Van der Sluis 《Journal of forecasting》2008,27(1):21-39
Often, a relatively small group of trades causes the major part of the trading costs on an investment portfolio. Consequently, reducing the trading costs of comparatively few expensive trades would already result in substantial savings on total trading costs. Since trading costs depend to some extent on steering variables, investors can try to lower trading costs by carefully controlling these factors. As a first step in this direction, this paper focuses on the identification of expensive trades before actual trading takes place. However, forecasting market impact costs appears notoriously difficult and traditional methods fail. Therefore, we propose two alternative methods to form expectations about future trading costs. Applied to the equity trades of the world's second largest pension fund, both methods succeed in filtering out a considerable number of trades with high trading costs and substantially outperform no‐skill prediction methods. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
235.
Spectrin mutations cause spinocerebellar ataxia type 5 总被引:12,自引:0,他引:12
Ikeda Y Dick KA Weatherspoon MR Gincel D Armbrust KR Dalton JC Stevanin G Dürr A Zühlke C Bürk K Clark HB Brice A Rothstein JD Schut LJ Day JW Ranum LP 《Nature genetics》2006,38(2):184-190
We have discovered that beta-III spectrin (SPTBN2) mutations cause spinocerebellar ataxia type 5 (SCA5) in an 11-generation American kindred descended from President Lincoln's grandparents and two additional families. Two families have separate in-frame deletions of 39 and 15 bp, and a third family has a mutation in the actin/ARP1 binding region. Beta-III spectrin is highly expressed in Purkinje cells and has been shown to stabilize the glutamate transporter EAAT4 at the surface of the plasma membrane. We found marked differences in EAAT4 and GluRdelta2 by protein blot and cell fractionation in SCA5 autopsy tissue. Cell culture studies demonstrate that wild-type but not mutant beta-III spectrin stabilizes EAAT4 at the plasma membrane. Spectrin mutations are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling. 相似文献
236.
Deficiency of hyccin, a newly identified membrane protein, causes hypomyelination and congenital cataract 总被引:1,自引:0,他引:1
Zara F Biancheri R Bruno C Bordo L Assereto S Gazzerro E Sotgia F Wang XB Gianotti S Stringara S Pedemonte M Uziel G Rossi A Schenone A Tortori-Donati P van der Knaap MS Lisanti MP Minetti C 《Nature genetics》2006,38(10):1111-1113
We describe a new autosomal recessive white matter disorder ('hypomyelination and congenital cataract') characterized by hypomyelination of the central and peripheral nervous system, progressive neurological impairment and congenital cataract. We identified mutations in five affected families, resulting in a deficiency of hyccin, a newly identified 521-amino acid membrane protein. Our study highlights the essential role of hyccin in central and peripheral myelination. 相似文献
237.
238.
Several years ago, we described Myc as “the oncogene from hell”, since evidence had just emerged that Myc, aside from being
responsible for cell-cycle progression and tumor expansion, was also able to induce genomic instability in culture, wreaking
havoc in tumor cells and accelerating tumor progression (Soucek and Evan, Cancer Cell 1:406–408, 2002; Vafa et al., Mol Cell 9:1031–1044, 2002). In this review, we discuss recent publications that expand Myc’s evil armory to include coordination of the crosstalk between
tumor and microenvironment. Indeed, endogenous Myc, acting as a client for upstream oncogenic lesions, instructs the tumor
stroma, engages a complex inflammatory response and induces angiogenesis, thus allowing the tumor to thrive. This is highly
topical in light of the fact that Hanahan and Weinberg have recently redefined the hallmarks of cancer and pointed out that
genomic instability and inflammation are essential for both their acquisition and development (Hanahan and Weinberg, Cell
144:646–674, 2011). Myc, it seems, is behind it all. 相似文献
239.
Groesser L Herschberger E Ruetten A Ruivenkamp C Lopriore E Zutt M Langmann T Singer S Klingseisen L Schneider-Brachert W Toll A Real FX Landthaler M Hafner C 《Nature genetics》2012,44(7):783-787
Nevus sebaceous is a common congenital cutaneous malformation. Affected individuals may develop benign and malignant secondary tumors in the nevi during life. Schimmelpenning syndrome is characterized by the association of nevus sebaceous with extracutaneous abnormalities. We report that of 65 sebaceous nevi studied, 62 (95%) had mutations in the HRAS gene and 3 (5%) had mutations in the KRAS gene. The HRAS c.37G>C mutation, which results in a p.Gly13Arg substitution, was present in 91% of lesions. Nonlesional tissues from 18 individuals had a wild-type sequence, confirming genetic mosaicism. The HRAS c.37G>C mutation was also found in 8 of 8 associated secondary tumors. Mosaicism for HRAS c.37G>C and KRAS c.35G>A mutations was found in two individuals with Schimmelpenning syndrome. Functional analysis of HRAS c.37G>C mutant cells showed constitutive activation of the MAPK and PI3K-Akt signaling pathways. Our results indicate that nevus sebaceous and Schimmelpenning syndrome are caused by postzygotic HRAS and KRAS mutations. These mutations may predispose individuals to the development of secondary tumors in nevus sebaceous. 相似文献
240.