信息系统外包:主要研究方向和未来发展趋势

近年来,信息系统外包已经成为众多美国财富500强的公司和一些欧洲大型跨国公司(M NC s)所关注的问题。一份最新的调查报告显示接近1/3的财富500强公司选择了印度作为它们外包业务的所在地。自1990年以来,印度政府一直致力于支持和推动信息系统外包产业的发展,并取得了巨大的成效。该文试通过对一些关键问题的讨论来探索这个重要的研究领域,这些问题包括:欧美公司为何将信息系统外包,印度怎样成为了全球信息系统外包的领导国家,中国的IT产业如何迎头赶上加入信息系统外包这个有利可图的市场的竞争。     

Global warming： Take action or wait？

Of all the changes wrought by human activity, the buildup in our atmosphere of the greenhouse gases, carbon dioxide, methane and nitrous oxide, has gener- ated the most contentious debate. Environmentalists warn that in the absence of firm action, over th…     

智能住宅中消防给水系统设计探讨

根据智能住宅火灾形成的特点，简述了消火栓给水系统与自动喷水灭火系统的设置方式与特点，并结合实例对消防给水方式的选择等问题进行了探讨。     

指纹识别系统的分析与研究

介绍了一种新型的指纹识别装置(晶体传感器的指纹识别装置)，并借此分析和研究了指纹识别系统的识别原理和设计方法，这些原理和方法对指导和优化指纹识别系统的设计提供了依据。     

科技创新是时代发展的永恒主题

从科技创新的基本特征、类型分析入手，总结介绍了国际科技创新的发展经验与启示，并结合我国国情，提出现阶段我国科技创新的战略框架和基本对策。     

过江光缆施工技术

以新长铁路为例，从施工前、施工中及施工后的具体情况出发，对过江光缆施工技术进行了详细的说明，就如何减小风险提出了一些建议。     

Growth of Magnetite Nanoparticles under Magnetic Fields

1 Introduction Over the past several years, the preparation and characterization ofnanoscale magnetic materials, especially one-dimensional (1D) nanostructure, have attracted much attention as the nanomaterials would allow investigating the fundamental aspects of magnetic-ordering phenomena in magnetic materials with reduced dimensions and could lead to new potential applications such as data storage technology[1-6].     

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Among these tyrosine residues, Y842 is located in the so-called activation loop. The position of this tyrosine residue is well conserved in all receptor tyrosine kinases. It has been reported that phosphorylation of the activation loop tyrosine is critical for catalytic activity for some but not all receptor tyrosine kinases. The role of Y842 residue in FLT3 signaling has not yet been studied. In this report, we show that Y842 is not important for FLT3 activation or ubiquitination but plays a critical role in regulating signaling downstream of the receptor as well as controlling receptor stability. We found that mutation of Y842 in the FLT3-ITD oncogenic mutant background reduced cell viability and increased apoptosis. Furthermore, the introduction of the Y842 mutation in the FLT3-ITD background led to a dramatic reduction in in vitro colony forming capacity. Additionally, mice injected with cells expressing FLT3-ITD/Y842F displayed a significant delay in tumor formation, compared to FLT3-ITD expressing cells. Microarray analysis comparing gene expression regulated by FLT3-ITD versus FLT3-ITD/Y842F demonstrated that mutation of Y842 causes suppression of anti-apoptotic genes. Furthermore, we showed that cells expressing FLT3-ITD/Y842F display impaired activity of the RAS/ERK pathway due to reduced interaction between FLT3 and SHP2 leading to reduced SHP2 activation. Thus, we suggest that Y842 is critical for FLT3-mediated RAS/ERK signaling and cellular transformation.