Ⅱ型糖尿病：不再是噩梦

由一个优势型缺陷基因或者两个隐性基因的遗传所导致的单基因异常很罕见,但也得到了较好的研究,例如囊性纤维化。但是对于哮喘、抑郁症和Ⅱ型糖尿病(T2D)这些被认为有家族遗传性的常见病,要认清其复杂的遗传学机理,在近期内几乎是不可能的。人类全基因组扫描、自动基因分型技术的进步、统计学分析新技术、国际合作、广泛的数据共享以及为了证实一些发现     

关于长方矩阵的加W权-Moore-Penrose逆的存在性

提出了长方矩阵的加形权-Moore—Penrose逆,给出了加形权-Moore—Penrose逆存在的充分必要奈件,计算方法及其应用．而且也给出了《关于长方矩阵的加权逆的存在性》一文中提出的加权群逆的存在性的新的充分必要条件．     

A hierarchical multiple criteria model for eliciting relative preferences in conflict situations

A multiple criteria decision analysis(MCDA) approach is designed for capturing the relative preference information of a decision maker involved in a conflict.More specifically,an MCDA approach based on the outranking method,ELECTRE III,is employed for ranking states or possible scenarios in the conflict from most to least preferred,where ties are allowed,for a decision maker according to his or her value system.To demonstrate how this preference elicitation methodology can be conveniently implemented in practice within the framework of the Graph Model for Conflict Resolution,it is applied to a real world water supply crisis which occurred in the town of North Battleford,located in the Canadian province of Saskatchewan.     

基于径向基函数网络或模糊系统的非线性连续时间系统的自适应调节

对于一类连续时间的非线性动态系统x=f(x)+Bu+d,当系统中的非线性函数f(x)满足有界或线性增长条件(具有未知的增长系数)时,首先证明了f(x)中的x落入一紧集中,然后根据径向基函数网络或模糊系统的逼近性质,给出了两种自适应调节器的设计方法.利用李亚普诺夫稳定性理论,证明了控制算法是全局稳定的,闭环系统的状态是一致最终有界的,且控制律是稳定的.     

Decentralized Bezout Identity and a Parametrization of Decentralized Controllers for Singular Systems

1　 IntroductionConsider a singular decentralized control system of the formEx(t) =Ax(t) ∑Ni=1Biui(t)yi =Cix(t) ,i∈ N ={ 1 ,2 ,… ,N}(1 )where x(t)∈ Rn is the state vector,ui(t)∈ Rmi and yi(t)∈ Rpi are respectively the localcontrol input and measure outputvectors of the ith control channel.The matrix E may besingular,i.e.,rank(E) 相似文献   

云计算环境中SBS应用动态资源分配方法

建立了一个SBS（基于服务的系统,service based system）应用端到端性能评价模型,并在该模型的基础上提出了SBS应用动态资源分配方法,该方法通过将静态的初始资源分配和动态的资源分配方案调整相结合,能够适应用户访问行为的动态变化,保证SBS应用端到端性能. 在SBS应用动态资源分配问题求解中,提出了服务吞吐量约束确定算法并在此基础上 给出了SBS应用动态资源分配算法,该算法根据SBS应用吞吐量约束确定服务资源需求量并在此基础上通过起始服务 到服务间的转移时间计算服务的资源分配时刻,从而能够在保证SBS应用端到端性能约束的同时提高资源利用率. 实验验证了所提出的基于SBS应用端到端性能评价模型的动态资源分配方法的有效性.     

基于集中式模型的我国各地区及三大产业的DEA效率评价

基于集中式模型, 首先在考虑地区内部三大产业的情况下, 对2010年我国31个地区展开DEA效率评价, 然后在保持各地区整体效率不变的前提下进行效率分解, 确定各产业的效率值和相对重要程度. 此外, 对各地区三大产业的规模收益问行了研究. 实证分析结果表明, 各地区的整体效率值偏低, 第一产业的效率重要程度偏低, 第二产业和第三产业的效率均值相差不大, 但大部分地区的产业比第二产业的相对重要程度高. 此外, 从规模收益角度来看, 大部分地区整体处于规模收益递减阶段, 大多数地区的第一和第三产业均处于规模收益递增阶段, 绝大多数地区的第二产业已处于规模收益递减阶段.     

The molecular sociology of the cell

Proteomic studies have yielded detailed lists of the proteins present in a cell. Comparatively little is known, however, about how these proteins interact and are spatially arranged within the 'functional modules' of the cell: that is, the 'molecular sociology' of the cell. This gap is now being bridged by using emerging experimental techniques, such as mass spectrometry of complexes and single-particle cryo-electron microscopy, to complement traditional biochemical and biophysical methods. With the development of integrative computational methods to exploit the data obtained, such hybrid approaches will uncover the molecular architectures, and perhaps even atomic models, of many protein complexes. With these structures in hand, researchers will be poised to use cryo-electron tomography to view protein complexes in action within cells, providing unprecedented insights into protein-interaction networks.