全文获取类型
收费全文 | 12660篇 |
免费 | 34篇 |
国内免费 | 41篇 |
专业分类
系统科学 | 77篇 |
丛书文集 | 32篇 |
教育与普及 | 64篇 |
理论与方法论 | 76篇 |
现状及发展 | 4893篇 |
研究方法 | 573篇 |
综合类 | 6729篇 |
自然研究 | 291篇 |
出版年
2012年 | 197篇 |
2011年 | 509篇 |
2010年 | 86篇 |
2009年 | 94篇 |
2008年 | 216篇 |
2007年 | 250篇 |
2006年 | 249篇 |
2005年 | 246篇 |
2004年 | 322篇 |
2003年 | 248篇 |
2002年 | 247篇 |
2001年 | 370篇 |
2000年 | 379篇 |
1999年 | 277篇 |
1992年 | 237篇 |
1991年 | 175篇 |
1990年 | 183篇 |
1989年 | 195篇 |
1988年 | 195篇 |
1987年 | 202篇 |
1986年 | 184篇 |
1985年 | 268篇 |
1984年 | 191篇 |
1983年 | 150篇 |
1982年 | 121篇 |
1981年 | 123篇 |
1980年 | 153篇 |
1979年 | 361篇 |
1978年 | 274篇 |
1977年 | 260篇 |
1976年 | 246篇 |
1975年 | 264篇 |
1974年 | 325篇 |
1973年 | 303篇 |
1972年 | 254篇 |
1971年 | 379篇 |
1970年 | 504篇 |
1969年 | 353篇 |
1968年 | 343篇 |
1967年 | 352篇 |
1966年 | 381篇 |
1965年 | 243篇 |
1964年 | 113篇 |
1959年 | 122篇 |
1958年 | 233篇 |
1957年 | 137篇 |
1956年 | 142篇 |
1955年 | 107篇 |
1954年 | 92篇 |
1948年 | 134篇 |
排序方式: 共有10000条查询结果,搜索用时 265 毫秒
941.
942.
A general survey of the information presently available on the osteology and myology of the hyobranchial apparatus. Included in the survey are examples of the hyobranchial skeleton of the major groups of reptiles, including the Chelonia, Crocodilia, Rhynchocephalia, and Squamata. The myology treats the muscles directly associated with the hyoid as well as those associated with the functioning of the apparatus, but not arising or inserted directly on or from the hyoid. The innervation of the hyobranchial apparatus is reviewed and briefly discussed based on the information available in a few major studies. An attempt is made to cite all pertinent literature references, and in Tables 1 and 2 the references to basic areas are indicated. Twenty - nine plates and figures are included, some of which represent original research. 相似文献
943.
944.
Grace W. C. Cheung Andrea Kokorovic Tony K. T. Lam 《Cellular and molecular life sciences : CMLS》2009,66(18):3023-3027
Upon the entry of nutrients into the small intestine, nutrient sensing mechanisms are activated to allow the body to adapt
appropriately to the incoming nutrients. To date, mounting evidence points to the existence of an upper intestinal lipid-induced
gut–brain neuronal axis to regulate energy homeostasis. Moreover, a recent discovery has also revealed an upper intestinal
lipid-induced gut–brain–liver neuronal axis involved in the regulation of glucose homeostasis. In this mini-review, we will
focus on the mechanisms underlying the activation of these respective neuronal axes by upper intestinal lipids. 相似文献
945.
Thirty-nine previously unpublished reports of the endangered black-footed ferret from Wyoming are listed with dates, locations, number of animals, sources, and comments. 相似文献
946.
947.
Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. 总被引:19,自引:0,他引:19
P J Miettinen J R Chin L Shum H C Slavkin C F Shuler R Derynck Z Werb 《Nature genetics》1999,22(1):69-73
Craniofacial malformations are among the most frequent congenital birth defects in humans; cleft palate, that is inadequate fusion of the palatal shelves, occurs with an annual incidence of 1 in 700 to 1 in 1,000 live births among individuals of European descent. The secondary palate arises as bilateral outgrowths from the maxillary processes, and its formation depends on the coordinated development of craniofacial structures including the Meckel's cartilage and the mandible. Cleft lip and palate syndromes in humans are associated with polymorphisms in the gene (TGFA) encoding transforming growth factor-alpha (TGF-alpha), an epidermal growth factor receptor (EGFR) ligand made by most epithelia. Here we have characterized craniofacial development in Egfr-deficient (Egfr-/-) mice. Newborn Egfr-/- mice have facial mediolateral defects including narrow, elongated snouts, underdeveloped lower jaw and a high incidence of cleft palate. Palatal shelf explants from Egfr-/- mice fused, but frequently had residual epithelium in the midline. In addition, morphogenesis of Meckel's cartilage was deficient in cultured mandibular processes from Egfr-/- embryos. The secretion of matrix metalloproteinases (MMPs) was diminished in Egfr-/- explants, consistent with the ability of EGF to increase MMP secretion and with the decreased MMP expression caused by inhibition of Egfr signalling in wild-type explants. Accordingly, inactivation of MMPs in wild-type explants phenocopied the defective morphology of Meckel's cartilage seen in Egfr-/- explants. Our results indicate that EGFR signalling is necessary for normal craniofacial development and that its role is mediated in part by its downstream targets, the MMPs, and may explain the genetic correlation of human cleft palate with polymorphisms in TGFA. 相似文献
948.
In rats, the vertebral artery make only a minor contribution to the blood perfusion of the ponto-medullary area. This was measured with radioactive microspheres and was confirmed by methylmetacrylate casts and local injection of a centrally acting hypotensive drug. 相似文献
949.
A family of mammalian Na+-dependent L-ascorbic acid transporters. 总被引:10,自引:0,他引:10
H Tsukaguchi T Tokui B Mackenzie U V Berger X Z Chen Y Wang R F Brubaker M A Hediger 《Nature》1999,399(6731):70-75
Vitamin C (L-ascorbic acid) is essential for many enzymatic reactions, in which it serves to maintain prosthetic metal ions in their reduced forms (for example, Fe2+, Cu+), and for scavenging free radicals in order to protect tissues from oxidative damage. The facilitative sugar transporters of the GLUT type can transport the oxidized form of the vitamin, dehydroascorbic acid, but these transporters are unlikely to allow significant physiological amounts of vitamin C to be taken up in the presence of normal glucose concentrations, because the vitamin is present in plasma essentially only in its reduced form. Here we describe the isolation of two L-ascorbic acid transporters, SVCT1 and SVCT2, from rat complementary DNA libraries, as the first step in investigating the importance of L-ascorbic acid transport in regulating the supply and metabolism of vitamin C. We find that SVCT1 and SVCT2 each mediate concentrative, high-affinity L-ascorbic acid transport that is stereospecific and is driven by the Na+ electrochemical gradient. Despite their close sequence homology and similar functions, the two isoforms of the transporter are discretely distributed: SVCT1 is mainly confined to epithelial systems (intestine, kidney, liver), whereas SVCT2 serves a host of metabolically active cells and specialized tissues in the brain, eye and other organs. 相似文献
950.