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排序方式: 共有235条查询结果,搜索用时 15 毫秒
81.
Chapman MA Lawrence MS Keats JJ Cibulskis K Sougnez C Schinzel AC Harview CL Brunet JP Ahmann GJ Adli M Anderson KC Ardlie KG Auclair D Baker A Bergsagel PL Bernstein BE Drier Y Fonseca R Gabriel SB Hofmeister CC Jagannath S Jakubowiak AJ Krishnan A Levy J Liefeld T Lonial S Mahan S Mfuko B Monti S Perkins LM Onofrio R Pugh TJ Rajkumar SV Ramos AH Siegel DS Sivachenko A Stewart AK Trudel S Vij R Voet D Winckler W Zimmerman T Carpten J Trent J Hahn WC Garraway LA Meyerson M Lander ES Getz G 《Nature》2011,471(7339):467-472
Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. Several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set. These include the mutation of genes involved in protein translation (seen in nearly half of the patients), genes involved in histone methylation, and genes involved in blood coagulation. In addition, a broader than anticipated role of NF-κB signalling was indicated by mutations in 11 members of the NF-κB pathway. Of potential immediate clinical relevance, activating mutations of the kinase BRAF were observed in 4% of patients, suggesting the evaluation of BRAF inhibitors in multiple myeloma clinical trials. These results indicate that cancer genome sequencing of large collections of samples will yield new insights into cancer not anticipated by existing knowledge. 相似文献
82.
83.
Antigens are generally thought to be recognized by cytotoxic T lymphocytes as peptides in the context of class I major histocompatibility proteins complex, which are heterodimers of heavy chains noncovalently associated with beta 2-microglobulin (beta 2m). The highly polymorphic nature of the heavy chains and their resulting ability to present different sets of peptides has presumably evolved to allow potent immune responses against most pathogens. By contrast, the polymorphism of beta 2m is limited; seven alleles are known in the mouse and only one has been identified in humans. beta 2-Microglobulin was consequently thought to have only structural functions: namely, to ensure correct folding of class I molecules and their transport to the cell surface. Although beta 2m is not implicated directly in the formation of the peptide binding site, we report here that it participates in the selection of MHC class I molecule-associated peptides. 相似文献
84.
陈式 《暨南大学学报(自然科学与医学版)》1994,(3)
从广东省花都市产银环蛇(Bungarusmulticintus)蛇毒纯化得到两个K-神经毒素(K-NT):Ⅵ2d峰及Ⅷ1b峰。两者的分子量均为6500,等电聚焦PI值均为9.1。Ⅵ2d峰N端部分43个氨基酸顺序与台湾姐环蛇的K-BGT完全一致,后者是当前唯一可用于神经元烟碱乙酰胆碱受体分型的毒素探针。至此,从中国大陆产的银环蛇毒中找到K-NT家族中3个成员即:K-BGT、K_2-BGT及K_3-BGT. 相似文献
85.
S. Abrahamsson R. J. Gryglewski L. Hellgren J. Splawinski J. Vincent B. Wojtaszek 《Cellular and molecular life sciences : CMLS》1981,37(2):164-166
Summary The activity spectrum of prostaglandin-like substances (PLS) fromP. acnes was investigated with cascade superfusion technique and by platelet aggregation assay. The biological activity of PLS resembles that of PGI2: both relax bovine coronary artery, rabbit mesentric and coeliac arteries; both contract the rat stomach strip as well as both typically inhibit spontaneous movements of isolated guinea pig ileum. Also, similarly to PGI2, PLS inhibits platelet aggregation regardless the inducer used. However, PLS possesses a specific antiaggregatory pattern on platelet, which indicates that these compounds are not indentical with primary prostaglandins or PGI2. 相似文献
86.
L. Dufy-Barbe F. Rodriguez J. D. Vincent 《Cellular and molecular life sciences : CMLS》1982,38(6):706-707
Summary Intracerebroventricular injections of angiotensin II (A II) induced a sharp and dose-dependent increase in plasma prolactin (PRL) levels in the awake Rhesus monkey. Our results suggest that in primates, A II may be involved in the mechanisms controlling PRL secretion.Acknowledgments. We thank Mrs. J. Arsaut and D. Verrier for excellent technical assistance. This work was supported by grants from INSERM (CRL No. 78.1.2656), DGRST (77.7.9654) and CNRS (ERA 493). 相似文献
87.
Heart failure is the leading cause of death worldwide, and current therapies only delay progression of the disease. Laboratory experiments and recent clinical trials suggest that cell-based therapies can improve cardiac function, and the implications of this for cardiac regeneration are causing great excitement. Bone-marrow-derived progenitor cells and other progenitor cells can differentiate into vascular cell types, restoring blood flow. More recently, resident cardiac stem cells have been shown to differentiate into multiple cell types present in the heart, including cardiac muscle cells, indicating that the heart is not terminally differentiated. These new findings have stimulated optimism that the progression of heart failure can be prevented or even reversed with cell-based therapy. 相似文献
88.
Subbaiah Annadurai Thiyagarajan Kalyani Vincent Rajkumar Dare Durairaj Gnanaraj Thomas 《自然科学进展(英文版)》2008,18(5):617-622
P systems generating rectangular arrays and hexagonal arrays have been studied in the literature, bringing together the two areas of theoretical computer science, namely membrane computing and picture languages. Recently, a new class of picture languages called the class of iso-picture languages generating interesting picture languages has been introduced. In this paper, we develop a class of tissue-like P systems with active membranes as a generative device for iso-picture languages. 相似文献
89.
Subbaiah Annadurai Thiyagarajan Kalyani Vincent Rajkumar Dare Durairaj Gnanaraj Thomas 《自然科学进展(英文版)》2008,18(5)
P systems generating rectangular arrays and hexagonal arrays have been studied in the literature,bringing together the two areas of theoretical computer science,namely membrane computing and picture languages.Recently,a new class of picture languages called the class of iso-picture languages generating interesting picture languages has been introduced.In this paper,we develop a class of tissue-like P systems with active membranes as a generative device for iso-picture languages. 相似文献
90.
Subbaiah Annadurai Thiyagarajan Kalyani Vincent Rajkumar Dare Durairaj Gnanaraj Thomas 《自然科学进展》2008,18(5):2008611-2008616
Membrane Computing is a branch of natural computing aiming to abstract computing ideas for the structure and the functioning of living cells as well as from the way the cells are organized in tissues or higher order structures. Trajectories are used as a tool for modeling language operations and other related objects. A trajectory P system consists of a membrane structure in which the object in each membrane is a collection of words and the evolutionary rules are given in terms of trajectories. In this paper, we present some properties of trajectory P systems. 相似文献