基于模糊C均值聚类的二维直流电阻率与射频大地电磁联合反演

为结合直流电阻率（direct current resistivity, DCR）与射频大地电磁（radio-magnetotelluric, RMT）法反演优势,开展了二维DCR与RMT数据联合反演研究。在经典最小结构模型正则化的基础上,采用平衡算子调节两个数据间的权重,引入模糊C均值（fuzzy C-means, FCM）聚类对电阻率模型进行约束,根据数据均方根误差自动调整FCM聚类项的权重,提高了联合反演效果。通过单独反演与联合反演结果的对比,分析了两种方法的反演能力,总结了联合反演的优势。模型试算表明,DCR与RMT数据联合反演得到的电阻率模型较单独反演更接近实际模型,FCM聚类约束的应用可进一步提高联合反演的效果。     

Pharmacological versus binding analysis of receptor systems: How do they interplay? Myometrial cell receptors for oxytocin as a paradigm

Summary Binding studies in various biological systems frequently indicate the presence of several binding sites for a biologically active ligand. They differ in their affinity for the ligand in question, binding capacity, and Hill coefficient, which suggests differences in the mechanisms of the binding site-ligand interactions. Identification of the true receptors (sites initiating a cellular response) appears to be difficult. Three clusters of binding sites for oxytocin were found on rat myometrial cells. The oxytocin receptor seems to be linked to the medium-affinity site; the cooperation between the high-and medium-affinity sites in eliciting the uterotonic response seems likely, but lacks experimental proof. Dose-response analysis in partially irreversibly inhibited uterus preparations, the method of equipotent doses (Furchgott-Bursztyn method), and structure-activity analysis of oxytocin-like peptides acting as competitive inhibitors of oxytocin, turned out to be suitable for pharmacological analysis of this receptor system.     

Tamoxifen ‘sex reverses’ alligator embryos at male producing temperature,but is an antiestrogen in female hatchlings

Summary Tamoxifen is an anticancer drug widely used in the treatment of estrogen-dependent breast cancer. In hatchling alligators it acts as a pure antiestrogen in that it completely blocks the effect of estradiol-induced oviductal hypertrophy and completely blocks the estradiol-induced hepatic vitellogenin secretion. Paradoxically, when injected into alligator eggs incubated at 33°C, a temperature which would normally result in 100% male hatchlings, tamoxifen sex reverses the embryos into apparently normal female hatchlings.