The suitability of intracutaneous infection in guinea pigs induced by virulent tubercle bacilli for the use in chemotherapeutic trials

Zusammenfassung Versuche mit intrakutan infizierten Meerschweinchen ergaben eine lineare Abhängigkeit zwischen der Flächengrösse der entstandenen Läsionen und dem Zeitinterval nach der Infektion. Modellversuche mit Isoniazid haben die gute Brauchbarkeit dieser Methode für chemotherapeutische Zwecke bewiesen.     

Mucosal growth effect of Vitamin D on the duodenum

Zusammenfassung Nach mehrmonatiger Vitamin-D-freier Diät erhielt eine Testgruppe von Ratten Vitamin D. Diese zeigte in Vergleich zur Kontrollgruppe eine Zunahme des Schleimhautgewichtes im Duodenum, nicht aber im Ileum.

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This work was supported in part by Training Grant No. T₁AM 5390 and Research Grant No. AM 02354 from the National Institutes of Health.     

“数据铁笼”:技术反腐的新探索

文章按照理论研究与实证研究相结合的方法,介绍“数据铁笼”的内涵,研究“数据铁笼”如何制约及监督权力,分析“数据铁笼”反腐的主要做法与进展,总结了“数据铁笼”贵阳模式的探索经验和取得的成效。     

浅议超高层建筑密集区域消防规划设计编制——以天津滨海新区于家堡金融区为例

随着我国城镇化建设的快速发展,国内很多城市都在规划建设中央商务区,文中基于高层建筑火灾蔓延快、人员疏散难、消防扑救难等难题,探讨如何从规划设计层面优化解决高层建筑密集区域的消防应急灭火救援体系,利用天津滨海新区于家堡金融区消防专项规划的编制实践,从消防队站选址优化,“空中、地面、地下”立体消防力量的科学合理布置,消防水池合建条件,施工期消防保障体系以及消防应急指挥信息整合等5个方面提出消防规划设计的具体措施,以期为相关区域消防系统规划建设提供借鉴.     

会计电算化、网络化对未来会计工作产生的影响

从会计本质的目标定位，会计报告内容的重要定义，会计报告传递方式的变化几个方面论述了会计电算化、网络化对未来会计工作产生的影响。实行会计信息系统、管理信息系统和信息集成己成为网络化经济中的必然趋势。     

我国绿色节能建筑发展的综述

本文从多角度,阐述我国绿色建筑的发展状况,并指出目前我国在绿色建筑方面存在的问题,提出推动绿色建筑发展的若干建议,为我区绿色节能建筑的发展提供参考依据。     

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

Ovarian carcinomas with mutations in the tumour suppressor BRCA2 are particularly sensitive to platinum compounds. However, such carcinomas ultimately develop cisplatin resistance. The mechanism of that resistance is largely unknown. Here we show that acquired resistance to cisplatin can be mediated by secondary intragenic mutations in BRCA2 that restore the wild-type BRCA2 reading frame. First, in a cisplatin-resistant BRCA2-mutated breast-cancer cell line, HCC1428, a secondary genetic change in BRCA2 rescued BRCA2 function. Second, cisplatin selection of a BRCA2-mutated pancreatic cancer cell line, Capan-1 (refs 3, 4), led to five different secondary mutations that restored the wild-type BRCA2 reading frame. All clones with secondary mutations were resistant both to cisplatin and to a poly(ADP-ribose) polymerase (PARP) inhibitor (AG14361). Finally, we evaluated recurrent cancers from patients whose primary BRCA2-mutated ovarian carcinomas were treated with cisplatin. The recurrent tumour that acquired cisplatin resistance had undergone reversion of its BRCA2 mutation. Our results suggest that secondary mutations that restore the wild-type BRCA2 reading frame may be a major clinical mediator of acquired resistance to platinum-based chemotherapy.     

δ~(13)C and water-use efficiency indicated by δ~(13)C of different plant functional groups on Changbai Mountains, Northeast China

Leaf δ13C of different plant functional groups (trees, shrubs and forbs; evergreen and deciduous; annual, biennial and perennial) were examined on the Changbai Mountains, China. Life form has a significant influence on plant δ13C, suggesting that leaf δ13C is also ideal for distinguishing functional groups species in temperate and frigid zones with high humidity. Additionally, the difference of water-use efficiency (WUE) is significant among different plant functional groups. δ13C and WUE are in the followi...