Micturition behaviour of neonatally testosterone treated female dogs

Résumé Nous avons montré que si l'on traite des chiens nouveau-nés de sexe féminin par la testostérone, même durant peu de temps, on peut changer leur attitude femelle de miction qui devient, après la puberté, du type charactérisant le mâle adulte, avec élévation d'une patte postérieure. Il semble que la testostérone, avant ou peu après la naissance, joue un rôle dans l'organisation ou l'activation des centres nerveux génétiquement prédéterminés et en relation avec les voies réflexes liées au comportement de l'animal adulte selon son sexe.     

Über die Chemodifferenzierung der Stammganglien der Ratte

Summary In foetal rat stem ganglia originating from the diencephalon, chemodifferentiation and morphogenesis take place earlier than in those from the telencephalon. Between 3 and 10 days postnatally, enzyme activities of all regions largely level up; later, the structures from the telencephalon show higher activities. Exceptions are acid phosphatase and thiamine pyrophosphatase, whose activities are higher in the stem ganglia from the diencephalon than in those from the telencephalon. The globus pallidus behaves in every respect like the structures from the diencephalon.     

Effect of soaking and sowing of lentil seeds (Lens culinaris Med.) with or without seedcoats on seedling growth

Résumé Des substances inhibitrices de la croissance radiculaire sont présentés dans les téguments et les cotylédons des graines de Lentille. Leurs effets sont mis en évidence dans des germinations de graines préalablement imbibées et (ou) semées avec ou sans téguments.     

Effects ofα-amanition of nucleolar structure and metabolism inDrosophila hydei

Zusammenfassung Fünf Stunden nach Injektion von 0.5 g -Amanitin in Larven des III. Stadiums vonDrosophila hydei zeigen viele Nukleolen der Speicheldrüsenzellen eine Fragmentierung und die meisten eine erhöhte Markierung mit³H-Uridin. In Tieren, die mit -Amanitin behandelt wurden ist der Grad des³H-Uridin-Einbaus in 28 S- und 18 S-RNS geringer, während der Einbau in niedermolekulare RNS (3–7 S) im Vergleich mit Kontroltieren stark zugenommen hat.     

An approach for the in vitro screening of drugs for activity against leprosy

Summary Slow growing strains of mycobacteria isolated from leprous tissues present a characteristic resistance pattern to antibacterial agents that is comparable to drug sensitivity ofM. leprae in man.The Hansen Chair of Research is a foundation of Le Secours aux Lépreux (Canada) Inc..     

Amaninamide,a new toxin ofAmanita virosa mushrooms

Summary Amaninamide, a toxin closely related to the family of amatoxins, was found exclusively inAmanita virosa mushrooms. It differs from the well known toxin -amanitin in that it lacks the 6-hydroxyl group of the tryptophan unit, and from the toxin amanin found inAmanita phalloides by the presence of a carboxamide group instead of a carboxylic acid group.Communication No. 57 of the series: Components of the green deathcap toadstool Amanita phalloides. No. 56: E. Munekata, H. Faulstich and Th. Wieland, Liebigs Ann. Chem., in press.     

JAK3 mediatesc-myc gene expression induced by interleukin-2

C myc gene expression can be rapidly induced by IL 2 through intracellular signal transduction which is triggered by the interaction between IL 2 and its receptor (IL 2R). JAK3 which associates to the intracellular domain of IL_2R γ may play a critical role in this process. To reveal the action of JAK3 in c myc induction, a chimeric receptor gene IL_2R α/γ/Δ NJAK3 is constructed which consists of extracellular domain derived from IL 2R α subunit (IL_2R α), the transmembrane sequence derived from IL_2R γ and the cytoplasmic domain derived from the catalytic domain of JAK3 (Δ NJAK3), and then transfected this chimeric gene into mouse fibroblast cell line L929 β which had been transfected with IL_2R β gene and stably expressed IL_2R β in high level. In the transfectants coexpressing IL_2R β and α/γ/Δ NJAK3, the stimulation of IL_2 could intensively induce c myc gene expression. Because the whole cytoplasmic domain of IL_2R γ which could recruit signaling molecules was replaced by JAK3 and the c myc could be still induced by IL_2 in this situation, the results here gave the direct evidence demonstrating that JAK3 plays an important role in c myc gene expression induced by IL_2.