The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor–glutamate NMDA receptor cross-regulation

A series of pharmacological and physiological studies have demonstrated the functional cross-regulation between MOR and NMDAR. These receptors coexist at postsynaptic sites in midbrain periaqueductal grey (PAG) neurons, an area implicated in the analgesic effects of opioids like morphine. In this study, we found that the MOR-associated histidine triad nucleotide-binding protein 1 (HINT1) is essential for maintaining the connection between the NMDAR and MOR. Morphine-induced analgesic tolerance is prevented and even rescued by inhibiting PKC or by antagonizing NMDAR. However, in the absence of HINT1, the MOR becomes supersensitive to morphine before suffering a profound and lasting desensitization that is refractory to PKC inhibition or NMDAR antagonism. Thus, HINT1 emerges as a key protein that is critical for sustaining NMDAR-mediated regulation of MOR signaling strength. Thus, HINT1 deficiency may contribute to opioid-intractable pain syndromes by causing long-term MOR desensitization via mechanisms independent of NMDAR.     

Universal Distributed Estimation Scheme for a Bandwidth Constrained Ad Hoc Sensor Network

This paper describes a distributed estimation scheme (DES) for a bandwidth constrained ad hoc sensor network.The DES is universal in the sense that operations on all sensors are identical and independent of noise distribution.The scheme requires each sensor to transmit just a 1-bit message per observation.Simulation results show that the scheme achieves much better mean-squares error (MSE) performance than the simplified isotropic universal DES and even outperforms the isotropic universal DES which requires more than twice the bandwidth of this scheme.     

智能型电冰箱断电延迟保护器

本文介绍了一种智能型电冰箱断电保护器的电路、工作原理及其优点。     

试论散手运动中蹬腿技术的特点及其训练

散手运动中蹬腿技术有杀伤力大,有利于近距离击打,隐蔽性强,不易被对方防守等特点,其训练方法包括基本技术训练、针对性训练和实战性训练三个步骤.     

Response ofPhloeotribus scarabaeoides (Coleoptera,Scolytidae) to ethylene in an olfactometer

The role of ethylene, pure or in formulation, in the colonization behaviour of the olive bark beetle,Phloeotribus scarabaeoides (Coleoptera, Scolytidae) has been investigated in the laboratory. Ethylene has been found to be attractive in both sexes; the formulation ethrel 48 was active in an olfactometer up to several months. Ethylene, whose concentration varies with the developmental stage or the condition of the tree or its wood, may play an important role in the primary attraction of these scolytids to their host.     

Effect of copulation or vaginal stimulation on melanocyte-stimulating hormone content of the hypophysis

Résumé Dans le rat, 1 h après la copulation, la concentration de l'MSH de l'hypophyse présente une diminution statistiquement significative, autant chez le mâle que chez la femelle. La stimulation vaginale avec une baguette de verre provoqua 60 et 120 min plus tard une diminution de la concentration de plus de 50% de l'MSH de l'hypophyse. Au bout de 30 min, on n'a observé aucun changement. On en déduit que la copulation ou la stimulation vaginale libère l'MSH.

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This investigation was supported by grant No. NB 04732-03 from the NIH, US. Public health Service.