实用电子镇流器的设计

介绍一套简易的日光灯电子镇流器实用电路,阐明了它的电路组成、工作原理,并进行了简单的电路分析     

技术要求集成处理方法的实现

本文提出了一种对技术要求进行集成处理的方法，简化了ＣＡＤ系统中标注技术要求的过程．     

江西高等职业技术教育发展的探讨

江西省职业技术教育要发展必须要有龙头带动，以龙头为主建设一所集培训中心、专科职业技术学院、本科企业管理学院以及研究生层次的师范学院为一体的规模大的综合性多层次的职业技术大学或昌北职教城，大学采取目标模块教育方式才能使职业技术教育办出特点，具有竞争力。     

一类目标函数的单机随机调度问题

本文讨论了目标函数具有一般形式（一些调度问题的目标函数可归结为此形式）的单机随机调度问题，对此问题最优解的特征进行了研究，并在一定条件下将结果推广到机器随机故障的情形。     

工程造价案例教学研究

文章分析了工程造价专业实施案例教学的必要性,设计出了工程造价案例的教学内容,并详细阐述了实施过程和实施后的总结评价,对工程造价专业实施案例教学具有很好的参考价值。     

中美20世纪90年代高等教育财政来源比较

通过对中美20世纪90年代高等教育财政来源构成状况的比较分析,试图为解决我国高等教育筹措经费难的问题提供借鉴和启示.     

一类自适应随机搜索算法及DEDS优化

采用常规的优化方法难以解决一般ＤＥＤＳ的优化问题，本文提出了一种新的基于仿真的自适应随机搜索技术，用于解决这类问题。实践表明，这种方法具有较高的搜索速度及广泛的适用性。     

Localization of Golgi-resident glycosyltransferases

For many glycosyltransferases, the information that instructs Golgi localization is located within a relatively short sequence of amino acids in the N-termini of these proteins comprising: the cytoplasmic tail, the transmembrane spanning region, and the stem region (CTS). Also, one enzyme may be more reliant on a particular region in the CTS for its localization than another. The predominance of these integral membrane proteins in the Golgi has seen these enzymes become central players in the development of membrane trafficking models of transport within this organelle. It is now understood that the means by which the characteristic distributions of glycosyltransferases arise within the subcompartments of the Golgi is inextricably linked to the mechanisms that cells employ to direct the flow of proteins and lipids within this organelle.     

Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the involvement of CtrB in apoptosis. Exposure of RH-35 cells to H₂O₂ or palmitate induced the redistribution of lysosomal CtrB into the cytoplasm as a result of lysosomal membrane permeabilization (LMP). Suppression of CtrB significantly blocked apoptosis, while overexpression of CtrB sensitized apoptosis markedly. CtrB could cleave Bid under neutral conditions. In RH-35 cells with Bid silenced, apoptosis induced by CtrB protein was attenuated, suggesting that CtrB mediates apoptosis of RH-35 cells mainly through processing Bid. Our data also suggest that LMP occurs earlier than mitochondrial outer membrane permeabilization; Bid activation initiated by caspase-8 might be reinforced by CtrB in consequence of LMP, which causes a positive feedback loop leading to the accumulation of tBid, and results in lysosome- and mitochondrion-dependent apoptosis.