全文获取类型
收费全文 | 124篇 |
免费 | 1篇 |
专业分类
系统科学 | 4篇 |
理论与方法论 | 1篇 |
现状及发展 | 20篇 |
研究方法 | 15篇 |
综合类 | 85篇 |
出版年
2020年 | 2篇 |
2018年 | 1篇 |
2017年 | 1篇 |
2016年 | 3篇 |
2015年 | 3篇 |
2013年 | 1篇 |
2012年 | 12篇 |
2011年 | 4篇 |
2010年 | 3篇 |
2009年 | 3篇 |
2008年 | 3篇 |
2007年 | 4篇 |
2006年 | 3篇 |
2005年 | 3篇 |
2004年 | 3篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 3篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1996年 | 8篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 5篇 |
1989年 | 6篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 4篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1970年 | 2篇 |
排序方式: 共有125条查询结果,搜索用时 15 毫秒
81.
Ruth Nussinov Hyunbum Jang Chung-Jung Tsai Tsung-Jen Liao Shuai Li David Fushman Jian Zhang 《Cellular and molecular life sciences : CMLS》2017,74(17):3245-3261
How Ras, and in particular its most abundant oncogenic isoform K-Ras4B, is activated and signals in proliferating cells, poses some of the most challenging questions in cancer cell biology. In this paper, we ask how intrinsically disordered regions in K-Ras4B and its effectors help promote proliferative signaling. Conformational disorder allows spanning long distances, supports hinge motions, promotes anchoring in membranes, permits segments to fulfil multiple roles, and broadly is crucial for activation mechanisms and intensified oncogenic signaling. Here, we provide an overview illustrating some of the key mechanisms through which conformational disorder can promote oncogenesis, with K-Ras4B signaling serving as an example. We discuss (1) GTP-bound KRas4B activation through membrane attachment; (2) how farnesylation and palmitoylation can promote isoform functional specificity; (3) calmodulin binding and PI3K activation; (4) how Ras activates its RASSF5 cofactor, thereby stimulating signaling of the Hippo pathway and repressing proliferation; and (5) how intrinsically disordered segments in Raf help its attachment to the membrane and activation. Collectively, we provide the first inclusive review of the roles of intrinsic protein disorder in oncogenic Ras-driven signaling. We believe that a broad picture helps to grasp and formulate key mechanisms in Ras cancer biology and assists in therapeutic intervention. 相似文献
82.
83.
含卡宾或烯酮基铁簇合物作为乙醇合成机理模型的研究 总被引:4,自引:0,他引:4
用含卡宾或烯酮的铁簇合物为模型,在模拟多相反应的条件下,研究了它们与H_2,H_2/CO,H_2/CO/CH_3OH 和H_2/CO/CD_3OD 的反应行为。在95℃和2.0 MPa的条件下,Fe_2(μ-CH_2)(CO)_8/SiO_2与含有合成气的甲醇反应可得 43%的醋酸甲酯,同时伴有甲烷、乙烷、乙烯、乙醛和乙醇等产物。与引入全氘代甲醇的合成气反应后,可得到氘代产物DCH_2COOCD_3和CH_3 COOCD_3.DCH_2 COOCD_3与A_cOCD_3(=DCH_2COOCD_3+CH_3COOCD_3)的相对丰度比随CD_3OD与H_2比值的减小而降低,由此可推测烯酮加成与烯酮氢化成乙酰基中间体这一对竞争反应。 相似文献
84.
85.
14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome 总被引:4,自引:0,他引:4
Toyo-oka K Shionoya A Gambello MJ Cardoso C Leventer R Ward HL Ayala R Tsai LH Dobyns W Ledbetter D Hirotsune S Wynshaw-Boris A 《Nature genetics》2003,34(3):274-285
Heterozygous deletions of 17p13.3 result in the human neuronal migration disorders isolated lissencephaly sequence (ILS) and the more severe Miller-Dieker syndrome (MDS). Mutations in PAFAH1B1 (the gene encoding LIS1) are responsible for ILS and contribute to MDS, but the genetic causes of the greater severity of MDS are unknown. Here, we show that the gene encoding 14-3-3epsilon (YWHAE), one of a family of ubiquitous phosphoserine/threonine-binding proteins, is always deleted in individuals with MDS. Mice deficient in Ywhae have defects in brain development and neuronal migration, similar to defects observed in mice heterozygous with respect to Pafah1b1. Mice heterozygous with respect to both genes have more severe migration defects than single heterozygotes. 14-3-3epsilon binds to CDK5/p35-phosphorylated NUDEL and this binding maintains NUDEL phosphorylation. Similar to LIS1, deficiency of 14-3-3epsilon results in mislocalization of NUDEL and LIS1, consistent with reduction of cytoplasmic dynein function. These results establish a crucial role for 14-3-3epsilon in neuronal development by sustaining the effects of CDK5 phosphorylation and provide a molecular explanation for the differences in severity of human neuronal migration defects with 17p13.3 deletions. 相似文献
86.
87.
M. T. Lin W. Y. Chia C. T. Tsai T. H. Yin 《Cellular and molecular life sciences : CMLS》1978,34(6):756-757
Summary Intraventricular administration of 6-OHDA or 5,6-DHT suppressed food intake, whereas their effect on active avoidance produced a suppression with the former and an enhancement with the latter. The increased water intake was specifically associated with 5,6-DHT treatment in rats.This work supported by grants from the National Science Council (Republic of China), J. Aron Charitable Foundation (USA) and John B. Pierce Foundation (USA). The authors are grateful to Drs C.Y. Chai and H. H. Lu for their support and advice. 相似文献
88.
Actively transcribed genes are associated with the nuclear matrix 总被引:13,自引:0,他引:13
89.
应用群分解BHMO程序,研究了含S_2的固氮酶活性中心模型和N_2的络合活化模式.结果表明,在结构参数优化的情况下,平躺式络合与微斜插入式络合的键能差别不大(前者仅高约1ev),实际的络合方式很可能是直插式的或微斜插入式的,这样在加进1个H或两个H后,μ_3-H_2就转化为端基络合在Mo上的-N=NH或=N-NH_2。对奇数电子体系,由于其LUMO和NHOMO之间能级差别小,如对称性相同,易于产生d—d跃迁,从而为S=3/2的实验事实提供了可能的解释. 相似文献
90.
K. Wiesner E. W. K. Jay C. Demerson T. Kanno J. Křepinský Lizzie Poon T. Y. R. Tsai A. Vilím C. S. Wu 《Cellular and molecular life sciences : CMLS》1970,26(9):1030-1033
Zusammenfassung Die stereoselektive Totalsynthese eines Delphininabbauproduktes wird beschrieben. Dieses Produkt, das 5 Ringe und 5 Substituenten besitzt, ist von Delphinin aus leicht zugänglich und kann deshalb als Relais-Verbindung für die Totalsynthese dieses Alkaloids dienen.
Presented at a seminar at the Organic Chemistry Laboratory, ETH, Zurich, Switzerland on June 24, 1969. 相似文献
Presented at a seminar at the Organic Chemistry Laboratory, ETH, Zurich, Switzerland on June 24, 1969. 相似文献