The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.     

Reconsideration on Homogeneous Quadratic Riemann Boundary Value Problem

The homogeneous quadratic Riemann boundary value problem (1) with Hoelder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained.     

高考走向的争鸣与思考

高考走向何方,成为人们热议的话题。有人主张废除高考,有人反对废除,主张改革;有人赞成统一高考,有人赞成高校单独招考……笔者认为高考要改不宜废,但改革要考虑国情,要遵循一定原则,要有比较稳定的思路,要有灵活应变的策略和科学的方法。     

Abrupt climate change：Debate or action

Global abrupt climate changes have been documented by various climate records, including ice cores, ocean sediment cores, lake sediment cores, cave deposits, loess deposits and pollen records. The climate system prefers to be in one of two stable states, i.e. interstadial or stadial conditions, but not in between. The transition between two states has an abrupt character. Abrupt climate changes are, in general, synchronous in the northern hemisphere and tropical regions. The timescale for abrupt climate changes can be as short as a decade. As the impacts may be potentially serious, we need to take actions such as reducing CO2 emissions to the atmosphere.     

The Optimal Solution of the Model with Physical and Human Capital Adjustment Costs

We prove that the model with physical and human capital adjustment costs has optimal solution when the production function is increasing return and the structure of vetor fields of the model changes substantially when the prodution function from decreasing return turns to increasing return. And it is shown that the economy is improved when the coefficients of adjustment costs become small.     

Hamilton线图中的泛圈性

对于图Ｇ的边ｅ＝ｕｖ，定义ｄ（ｅ）－ｄ（ｕ）＋ｄ（ｖ），这里ｄ（ｕ）和ｄ（ｖ）分分别表示ｕ和ｖ的度，该文的主要结果是：对阶为ｎ（ｎ≥４０）的简单连通图Ｇ，如果对Ｇ中任意两条边距离为２的边ｅ１，ｅ２都有ｄ（ｅ１）＋ｄ（ｅ２）≥ｎ，并且线图Ｌ（Ｇ）是Ｈａｍｉｌｔｏｎ的，则Ｌ（Ｇ）是泛圈的，并且条件Ｌ（Ｇ）是Ｈａｍｉｌｔｏｎ是必要的。     

并行工程产品开发过程的建模方法学

在并行工程中，为了实现产品开发过程的集成、并行和最优化，首先要建立能够充分反映产品开发过程各方面信息的产品开发过程模型。通过对模型的仿真分析和优化，指导产品开发过程的实施。本文首先提出了并行工程产品开发过程模型是集成多视图模型，随后提出了采用集成多视图建模理论的并行工程产品开发过程建模、分析和管理的方法学框架     

借助Matlab遗传算法反演火山区压力源参数

首先分析了Mogi模型的经典最小二乘反演由于出现矩阵奇异或接近奇异而发散的局限性,决定采用具有全局高效搜索性和优化计算时不需要求导的遗传算法来反演火山区压力源参数。反演程序调用Matlab7.0 Release14工具箱中的选择、交叉和变异等相关程序。最后应用该程序和长白山天池火山区水准和GPS观测资料联合反演火山区压力源参数,经过比较遗传算法和阻尼最小二乘方法的反演结果,可看出2种方法结果近似,可见此方法方便快捷地实现了目标函数的最小化。     

Static extracting method of software intended behavior based on API functions invoking

The method of extracting and describing the intended behavior of software precisely has become one of the key points in the fields of software behavior＇s dynamic and trusted authentication. In this paper, the author proposes a specified measure of extracting SIBDS （software intended behaviors describing sets） statically from the binary executable using the software＇s API functions invoking, and also introduces the definition of the structure used to store the SIBDS in detail. Experimental results demonstrate that the extracting method and the storage structure definition offers three strong properties： （i） it can describe the software＇s intended behavior accurately; （ii） it demands a small storage expense; （iii） it provides strong capability to defend against mimicry attack.     

Comparison of Drought-Resistance about Three Wild Rocky-Grasses

In this experiment, using the methods of drought-stress in the pot and PEG simulative drought-stress, three native rocky-slope grasses Pogonatherum panideum（Lam.） Hack, Erioophorum comosum nees and Cynodon dactylon cultivated in the pots were selected as materials to study their drought-resistance by analyzing the indexes such as the leaf area index, the drying roots accumulation, the holding water ability of leaf, the relative conductance of leaf, the soluble protein, chlorophyll. At the same time, by comparing with membership function value of each index, the order of each grass drought-resistance was decided. The results showed that the drought-resistance of Erioophorum comosum nees was stronger than Cynodon dactylon and drought-resistance of Cynodon dactylon was stronger than Pogonatherum panideum （Lam.） Hack. The purpose of the experimental results was to find theoretical foundations for selecting and cultivating native protecting-slope vegetations to adapt to rocky slopes.