Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.     

大规模复杂决策问题求解的2+3模型及其分形性质

<正> 决策过程的任务是,选择一组互相联系的决策变量(决策行动、决策函数),在给定的环境条件或初始条件下,使一组互相冲突的要求得到某种意义上的满足。 研究决策方法的目的,是为了发现控制成功的复杂决策过程的一般规律,尤其是涉及开放的复杂巨系统的决策过程的一般规律,以便能     

知识管理与张謇研究特色数据库建设

以张謇研究特色数据库建设为例，简要论述了如何应用知识管理的工具和理念建设特色数据库。     

Abnormal pattern detected in fragile-X patients by pulsed-field gel electrophoresis.

The fragile-X syndrome is the most frequent inherited form of mental retardation, with an incidence of 1 in 1,500 males. It is characterized by the presence of a fragile site at Xq27.3 induced in vitro by folate deprivation or by inhibitors of deoxynucleotide synthesis. Its mode of inheritance is unusual for an X-linked trait, with incomplete penetrance in both males and females. Some phenotypically normal males transmit the mutation to all their daughters who rarely express any symptoms, but penetrance is high in sons and daughters of these carrier women. Genetic and physical mapping of the Xq27-q28 region has confirmed that the disease locus is located at or very near the fragile site. Hypotheses proposed to account for the abnormalities in the inheritance of the disease include sequence rearrangements by meiotic recombination or a mutation that affects reactivation of an inactive X chromosome during differentiation of female germ cells. To detect such rearrangements, or methylation changes that may reflect a locally inactive X chromosome, we used pulsed-field gel analysis of DNA from fragile-X patients with probes close to the fragile-X locus. The probe Do33 (DXS465) detected abnormal patterns in fragile-X patients, but not in normal controls or in non-expressing male transmitters.     

用测量模态阻尼和振型的方法对复合材料薄平板进行无损质量检测

复合材料薄平板经热压制成后,都需要进行质量检测。本文探索用测量模态阻尼和振型的方法,对复合材料薄平板的制作质量进行无损检测,作为对其它昂贵的无损检测方法的补充。略述用振动方法进行无损检测的原理,测量薄平板阻尼的方法以及提高测量精度的措施。还讨论在测量薄平板阻尼时可能遇到的一些特殊问题(如非线性刚度、拍、模态密集等问题);以云母基复合材料薄平板作为例子,从测量其阻尼和振型的结果,对这种板的制作质量进行讨论。     

Leaning Towards Agile in 21~(st) Century

Background: During the last fifteen years there ha s been an increased drive for organisations to reduce costs. From a production po int, this has often centred on lean manufacturing and JIT waste elimination proc esses. However, in 1991, the Iaccocca Institute Bethlehem P.A commissioned a re port specifically to analyse the changing nature of the marketplace. As a result , in the following year, the Agile Manufacturing Forum was initiated and the ter m ‘agile or responsive manufacturing‘ was first intr...     

无格式设计观

当 Kjell Ekhorn 还在学校学习图形设计,Jon Forss 已在这个行业里工作了不少年头。1989年 Jon Forss 于1LeicesterPolytechnic 毕业后就在 Bath 为一家广告代理商工作,四年之后他移居伦敦为 namara 设计公司设计图书封面。五年以后,他遇到从伦敦 Centrl St.Martins 学校毕业不过两年,正以自由职业者身份从事图书封面设计、图片制作和摄影工作的 Kjell Ekhorn。两人惊讶于互相对图书封面设计的看法,一时相见恨晚,然后自然而然的开始了两人合作的NON-FORMAT 时代。     

分块三级及矢量量化图像编码

本文提出了一种新的称为分块三级及矢量量化图像压缩编码方法。该方法是以分块截断编码技术和矢量量化技术为基础的编码方法。对两幅512×512×8静态测试图像进行的计算机模拟实验表明:平均编码率低于0.91比特/像素,即图像数据压缩比大于8.8倍,而信噪比不低于37dB,复原图像的主观质量较好。     

混合稀土氯化物催化合成了氧基吡喃的Diels－Alder反应

报道了混合稀土氯化物催化丙烯酸和乙烯基丁醚环加成反应的动力学行为．在温和条件下，反应收率可由非催化反应的５％提高到７４％，反应为二级反应。