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951.
952.
Comparison of the localization of several muscle proteins in relaxed and contracted myofibrils. 总被引:1,自引:0,他引:1
The localization of several muscle proteins in relaxed and contracted myofibrils is compared. The morphology of the myofibrils and the behavior of these proteins was also investigated under extraction conditions. 相似文献
953.
954.
955.
Multiple regulatory sites in large-conductance calcium-activated potassium channels 总被引:28,自引:0,他引:28
Large conductance, Ca(2+)- and voltage-activated K(+) channels (BK) respond to two distinct physiological signals -- membrane voltage and cytosolic Ca(2+) (refs 1, 2). Channel opening is regulated by changes in Ca(2+) concentration spanning 0.5 micro M to 50 mM (refs 2-5), a range of Ca(2+) sensitivity unusual among Ca(2+)-regulated proteins. Although voltage regulation arises from mechanisms shared with other voltage-gated channels, the mechanisms of Ca(2+) regulation remain largely unknown. One potential Ca(2+)-regulatory site, termed the 'Ca(2+) bowl', has been located to the large cytosolic carboxy terminus. Here we show that a second region of the C terminus, the RCK domain (regulator of conductance for K(+) (ref. 12)), contains residues that define two additional regulatory effects of divalent cations. One site, together with the Ca(2+) bowl, accounts for all physiological regulation of BK channels by Ca(2+); the other site contributes to effects of millimolar divalent cations that may mediate physiological regulation by cytosolic Mg(2+) (refs 5, 13). Independent regulation by multiple sites explains the large concentration range over which BK channels are regulated by Ca(2+). This allows BK channels to serve a variety of physiological roles contingent on the Ca(2+) concentration to which the channels are exposed. 相似文献
956.
Qiuli?Li Shuguang?LiEmail author Hongying?Zhou Huimin?Li Ji’an?Hong Qingchen?Wang H.?J.?Massonne 《科学通报(英文版)》2002,47(1):62-65
The U-Pb isotope compositions of rutile, omphacite and garnet in the eclogite from the Jinheqiao area in the Southern Dabie ultrahigh-pressure metamorphic zone were analyzed. The consistent high precision U-Pb age (218 ± 1.2) Ma of rutile in eclogite from the Dabie Mountains was obtained by two ways of isochron and common Pb correction based on the composition of omphacite. This proves that the omphacite in eclogite has a U/Pb ratio (m = 2.8) low enough to be used for common Pb correction in the analyses of rutile. Under the rapid cooling condition (40℃/Ma) the closure temperature for U-Pb diffusion in rutile is about 470℃. Thus, this U-Pb age of rutile proves that 218 Ma should be the cooling age of eclogite at 470℃ instead of the peak metamorphic age. 相似文献
957.
Calcineurin (CN) is thought to play a role in the synaptic plastivity and long-term potentiation (LTP) in the hippocampus.
Based on two LTP models in vivo, a specific inhibitor cyclosporin A (CsA) of CN was observed, which affected LTP in the hippocampal dentate gyrus of the
rats. The results indicated that CsA blocked LTP induced by high frequency stimulation (HFS) partly, but it had no effect
on the decrease of the onset and peak latency of population spikes (PS) except that it reduced the increase of the amplitude
after HFS. On the other hand, CsA blocked LTP induced by ginsenosides (GSS) completely. It suppressed the GSS-enhanced amplitude
of PS reversibly and blocked the decrease of the peak latency of PS induced by the GSS. These results suggest that the postsynaptic
CN plays a role in the induction of LTP in the hippocampus of the rats. 相似文献
958.
Zhuo?XuEmail author Shuguang?Zheng Zhenxing?Yue Yujun?Feng An?Jin Xi?Yao 《科学通报(英文版)》2002,47(6):513-518
The dielectric properties of Pb(Zn11/3Nb2/3)O3− BaTiO3−PbTiO3 relaxor ferroelectric ceramics near the rhombohedral and tetragonal phase boundary were investigated under hydrostatic pressure.
It was found that hydrostatic pressure made their phase transition temperature T
c and the peak temperature T
m decreased, and the frequency dispersion and relaxor behavior enhanced. In these disorder systems of composite pervoskite
structures, there appeared polar clusters or nanodomains. The unique physical characteristics, which made the relaxor behavior
enhanced, is that the correlation length among these nanodomains decreases greatly with the pressure increasing. 相似文献
959.
In eukaryotes, the ubiquitin-mediated protein degradation pathway has been shown to control several key biological processes such as cell division, development, metabolism and immune response. F-box proteins, as a part of SCF (Skp1-Cullin (or Cdc53)-F-box) complex, functioned by interacting with substrate proteins, leading to their subsequent degradation by the 26S proteasome. To date, several F-box proteins identified in Arabidopsis and Antirrhinum have been shown to play important roles in auxin signal transduction, floral organ formation, flowering and leaf senescence. Arabidopsis genome sequence analysis revealed that it encodes over 1000 predicted F-box proteins accounting for about 5% of total predicted proteins. These results indicate that the ubiquitin-mediated protein degradation involving the F-box proteins is an important mechanism controlling plant gene expression. Here, we review the known F-box proteins and their functionsin flowering plants. 相似文献
960.
Peat record reflecting Holocene climatic change in the Zoigê Plateau and AMS radiocarbon dating 总被引:2,自引:0,他引:2
Weijian?ZhouEmail author Xuefeng?Lu Zhengkun?Wu Lin?Deng A.?J.?T.?Jull D.?Donahue W.?Beck 《科学通报(英文版)》2002,47(1):66-70
Through the use of reliable AMS dating of high resolution (15–30 years) peat and the establishment of monsoon climate proxies
sequence, we have been able to recognize several cold, dry events in the Tibetan Plateau during the Holocene. The more obvious
ones occurred around 12800, 11300, 10200, 9580, 8900, 6400, 4400, 3700, 2800 and 1500 cal. aBP. These events correlate well
with both ice rafting events recorded in high latitude North Atlantic Ocean sediment cores and cooling events in the low latitude
SST. Spectral analysis indicates high frequency climate variation on centennial-millennial time scale during the Holocene.
This further reflects Holocene climate instability and the existence of centennial-millenium scale rhythm in mid latitude
areas as well. 相似文献