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Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6. 总被引:12,自引:0,他引:12
Human herpesvirus type-6 (HHV-6) is a recently isolated herpesvirus which is highly prevalent in adult populations around the world. HHV-6 was first isolated from the peripheral blood of six individuals with lymphoproliferative disorders, two of whom were also infected with human immunodeficiency virus. HHV-6, in common with other herpesviruses, transactivates the HIV long terminal repeat linked to reporter genes and has in addition been shown to accelerate HIV gene expression and CD4 cell death in cultures co-infected with both viruses. The virus is tropic for CD4+ lymphocytes and persists in the peripheral blood of most seropositive individuals. We have now identified a gene in HHV-6 encoding a 490-amino-acid polypeptide homologous to the human adeno-associated virus type-2 (AAV-2) rep gene. This gene has an essential role in AAV-2 DNA replication, can trans-regulate homologous and heterologous gene expression, and inhibits cellular transformation. The acquisition of rep by HHV-6 could be due to natural transfer of genetic information between DNA viruses of eukaryotes and is likely to have important consequences for the life-cycle of HHV-6 and for the host CD4 cell. 相似文献
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Gene-target recognition among members of the myc superfamily and implications for oncogenesis 总被引:16,自引:0,他引:16
O'Hagan RC Schreiber-Agus N Chen K David G Engelman JA Schwab R Alland L Thomson C Ronning DR Sacchettini JC Meltzer P DePinho RA 《Nature genetics》2000,24(2):113-119
Myc and Mad family proteins regulate multiple biological processes through their capacity to influence gene expression directly. Here we show that the basic regions of Myc and Mad proteins are not functionally equivalent in oncogenesis, have separable E-box-binding activities and engage both common and distinct gene targets. Our data support the view that the opposing biological actions of Myc and Mxi1 extend beyond reciprocal regulation of common gene targets. Identification of differentially regulated gene targets provides a framework for understanding the mechanism through which the Myc superfamily governs the growth, proliferation and survival of normal and neoplastic cells. 相似文献
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Evidence for a selective cytotoxic effect of carrageenan on cells of the immune system in vivo and in vitro 总被引:3,自引:0,他引:3
A. W. Thomson A. R. Wilson W. J. Cruickshank Audrey H. Jeffries 《Cellular and molecular life sciences : CMLS》1976,32(4):525-526
Summary Carrageenan suppressed antibody production to sheep erythrocytes in the mouse only when injected together with or 24 h prior to antigen. Pretreatment of sensitized spleen cell cultures with carrageenan reduced the degree of stimulation obtained using antigen but not PHA. 相似文献
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Role of portal blood supply in liver regeneration 总被引:1,自引:0,他引:1
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N. F. Hayes R. H. Thomson M. St. C. Flett 《Cellular and molecular life sciences : CMLS》1955,11(2):61-61
Zusammenfassung Die Infrarotspektren verschiedener Phenylurethane zeigen, dass diese die angenommene Struktur (II) besitzen und nicht molekulare Komplexe darstellen, wieIllari
et al.
1 annehmen. 相似文献