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61.
In its December 1990 fly-by of Earth, the Galileo spacecraft found evidence of abundant gaseous oxygen, a widely distributed surface pigment with a sharp absorption edge in the red part of the visible spectrum, and atmospheric methane in extreme thermodynamic disequilibrium; together, these are strongly suggestive of life on Earth. Moreover, the presence of narrow-band, pulsed, amplitude-modulated radio transmission seems uniquely attributable to intelligence. These observations constitute a control experiment for the serach for extraterrestrial life by modern interplanetary spacecraft. 相似文献
62.
p53 mutant mice that display early ageing-associated phenotypes. 总被引:56,自引:0,他引:56
Stuart D Tyner Sundaresan Venkatachalam Jene Choi Stephen Jones Nader Ghebranious Herbert Igelmann Xiongbin Lu Gabrielle Soron Benjamin Cooper Cory Brayton Sang Hee Park Timothy Thompson Gerard Karsenty Allan Bradley Lawrence A Donehower 《Nature》2002,415(6867):45-53
The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment. This mutation confers phenotypes consistent with activated p53 rather than inactivated p53. Mutant (p53+/m) mice exhibit enhanced resistance to spontaneous tumours compared with wild-type (p53+/+) littermates. As p53+/m mice age, they display an early onset of phenotypes associated with ageing. These include reduced longevity, osteoporosis, generalized organ atrophy and a diminished stress tolerance. A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing. 相似文献
63.
ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles 总被引:13,自引:0,他引:13
Renwick A Thompson D Seal S Kelly P Chagtai T Ahmed M North B Jayatilake H Barfoot R Spanova K McGuffog L Evans DG Eccles D;Breast Cancer Susceptibility Collaboration 《Nature genetics》2006,38(8):873-875
We screened individuals from 443 familial breast cancer pedigrees and 521 controls for ATM sequence variants and identified 12 mutations in affected individuals and two in controls (P = 0.0047). The results demonstrate that ATM mutations that cause ataxia-telangiectasia in biallelic carriers are breast cancer susceptibility alleles in monoallelic carriers, with an estimated relative risk of 2.37 (95% confidence interval (c.i.) = 1.51-3.78, P = 0.0003). There was no evidence that other classes of ATM variant confer a risk of breast cancer. 相似文献
64.
Hurley K Boggs SE Smith DM Duncan RC Lin R Zoglauer A Krucker S Hurford G Hudson H Wigger C Hajdas W Thompson C Mitrofanov I Sanin A Boynton W Fellows C von Kienlin A Lichti G Rau A Cline T 《Nature》2005,434(7037):1098-1103
Soft-gamma-ray repeaters (SGRs) are galactic X-ray stars that emit numerous short-duration (about 0.1 s) bursts of hard X-rays during sporadic active periods. They are thought to be magnetars: strongly magnetized neutron stars with emissions powered by the dissipation of magnetic energy. Here we report the detection of a long (380 s) giant flare from SGR 1806-20, which was much more luminous than any previous transient event observed in our Galaxy. (In the first 0.2 s, the flare released as much energy as the Sun radiates in a quarter of a million years.) Its power can be explained by a catastrophic instability involving global crust failure and magnetic reconnection on a magnetar, with possible large-scale untwisting of magnetic field lines outside the star. From a great distance this event would appear to be a short-duration, hard-spectrum cosmic gamma-ray burst. At least a significant fraction of the mysterious short-duration gamma-ray bursts may therefore come from extragalactic magnetars. 相似文献
65.
Larsson P Oyston PC Chain P Chu MC Duffield M Fuxelius HH Garcia E Hälltorp G Johansson D Isherwood KE Karp PD Larsson E Liu Y Michell S Prior J Prior R Malfatti S Sjöstedt A Svensson K Thompson N Vergez L Wagg JK Wren BW Lindler LE Andersson SG Forsman M Titball RW 《Nature genetics》2005,37(2):153-159
Francisella tularensis is one of the most infectious human pathogens known. In the past, both the former Soviet Union and the US had programs to develop weapons containing the bacterium. We report the complete genome sequence of a highly virulent isolate of F. tularensis (1,892,819 bp). The sequence uncovers previously uncharacterized genes encoding type IV pili, a surface polysaccharide and iron-acquisition systems. Several virulence-associated genes were located in a putative pathogenicity island, which was duplicated in the genome. More than 10% of the putative coding sequences contained insertion-deletion or substitution mutations and seemed to be deteriorating. The genome is rich in IS elements, including IS630 Tc-1 mariner family transposons, which are not expected in a prokaryote. We used a computational method for predicting metabolic pathways and found an unexpectedly high proportion of disrupted pathways, explaining the fastidious nutritional requirements of the bacterium. The loss of biosynthetic pathways indicates that F. tularensis is an obligate host-dependent bacterium in its natural life cycle. Our results have implications for our understanding of how highly virulent human pathogens evolve and will expedite strategies to combat them. 相似文献
66.
One of the great mysteries of the high-energy gamma-ray sky is the group of approximately 170 unidentified point sources found along the Galactic plane. They are more numerous than all other high-energy gamma-ray sources combined and, despite 20 years of effort, no clear counterparts have been found at other wavelengths. Here we report a new population of such objects. A cluster of approximately 20 faint sources appears north of the Galactic Centre, which is part of a broader class of faint objects at mid-latitudes. In addition, we show in a model-independent way that the mid-latitude sources are distinct from the population of bright unidentified sources along the Galactic plane. The distribution on the sky indicates that the faint mid-latitude sources are associated with the Gould belt of massive stars and gas clouds at approximately 600 light years distance, as has been previously suggested. 相似文献
67.
Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa 总被引:14,自引:0,他引:14
Gal A Li Y Thompson DA Weir J Orth U Jacobson SG Apfelstedt-Sylla E Vollrath D 《Nature genetics》2000,26(3):270-271
Mutation of a receptor tyrosine kinase gene, Mertk, in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration. We screened the human orthologue, MERTK, located at 2q14.1 (ref. 10), in 328 DNA samples from individuals with various retinal dystrophies and found three mutations in three individuals with retinitis pigmentosa (RP). Our findings are the first conclusive evidence implicating the RPE phagocytosis pathway in human retinal disease. 相似文献
68.
Growth patterns in the developing brain detected by using continuum mechanical tensor maps 总被引:19,自引:0,他引:19
The dynamic nature of growth and degenerative disease processes requires the design of sensitive strategies to detect, track and quantify structural change in the brain in its full spatial and temporal complexity. Although volumes of brain substructures are known to change during development, detailed maps of these dynamic growth processes have been unavailable. Here we report the creation of spatially complex, four-dimensional quantitative maps of growth patterns in the developing human brain, detected using a tensor mapping strategy with greater spatial detail and sensitivity than previously obtainable. By repeatedly scanning children (aged 3-15 years) across time spans of up to four years, a rostro-caudal wave of growth was detected at the corpus callosum, a fibre system that relays information between brain hemispheres. Peak growth rates, in fibres innervating association and language cortices, were attenuated after puberty, and contrasted sharply with a severe, spatially localized loss of subcortical grey matter. Conversely, at ages 3-6 years, the fastest growth rates occurred in frontal networks that regulate the planning of new actions. Local rates, profiles, and principal directions of growth were visualized in each individual child. 相似文献
69.
70.