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101.
根据古里雅冰芯中NO^-3浓度可以揭示太阳活动变化的事实,研究了长期以来存在争议的Maunder极小期(1645~1715年)的太阳活动状况,结果不仅证实这一时期太阳活动极小期的存在,而且也证实这一时期内太阳活动周期是正常的,即存在11a左右的黑子周期。研究还发现,太阳活动可能存在36a左右的周期,这一结果对于日地关系研究具有重要的意义。 相似文献
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c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells 总被引:10,自引:0,他引:10
Several lines of evidence suggest a role for the myc oncogene in cell proliferation. Most recently, mitogenic stimulation of quiescent lymphoid, fibroblast and epithelial cells has been demonstrated to lead to a sharp increase in c-myc RNA levels. To determine how c-myc expression is linked to the cell proliferative cycle, we have used centrifugal elutriation to enrich for populations of avian and human cells at different stages of the cell cycle. Centrifugal elutriation is a counterflow centrifugation method that separates cells on the basis of volume, a parameter correlating well with progression through the cell cycle. Using myc-specific anti-peptide antibodies, we show here that the synthesis, half-life and modification of c-myc proteins are constant throughout the cell cycle of normal and transformed cells. 相似文献
106.
Persistent neuronal plasticity, including that observed at some hippocampal synapses, requires N-methyl-D-aspartate (NMDA)-mediated transmission. NMDA receptor activation may be necessary for hippocampus-dependent learning as antagonists block acquisition in many such tasks. The behavioural effects of NMDA agonists are less well defined. We have shown that a monoclonal antibody (B6B21) displaced [3H]-glycine that was bound specifically to the NMDA receptor, and enhanced the opening of its integral cation channel in a glycine-like fashion, effects that were competitively antagonized by 7-chlorokynurenic acid. B6B21 also enhanced long-term potentiation in hippocampal slices. We report here that intraventricular infusions of B6B21 significantly enhances acquisition rates in hippocampus-dependent trace eye blink conditioning in rabbits, halving the number of trials required to reach a criterion of 80% conditioned responses. Peripheral injections of D-cycloserine, a partial agonist of the glycine site on the NMDA receptor which crosses the blood-brain barrier, also doubles rabbits' learning rates. Pseudoconditioning control experiments indicated a lack of nonspecific behavioural sensitization effects. Our data suggest that enhanced activation of the glycine coagonist site on the NMDA receptor/channel complex facilitates one form of associative learning and may be used in other learning tasks. 相似文献
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Structure of ferroverdin 总被引:2,自引:0,他引:2
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Mutator genes--pacemakers of evolution. 总被引:1,自引:0,他引:1
Initially a genetic oddity, male recombination in Drosophilaelanogaster is now being viewed as a means of detecting mutator activity and chromosome breakage in hybridising populations and is causing us to reconsider the source and rate at which genetic variability may be generated in nature. 相似文献
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Santorelli LA Thompson CR Villegas E Svetz J Dinh C Parikh A Sucgang R Kuspa A Strassmann JE Queller DC Shaulsky G 《Nature》2008,451(7182):1107-1110
Cooperation is central to many major transitions in evolution, including the emergence of eukaryotic cells, multicellularity and eusociality. Cooperation can be destroyed by the spread of cheater mutants that do not cooperate but gain the benefits of cooperation from others. However, cooperation can be preserved if cheaters are facultative, cheating others but cooperating among themselves. Several cheater mutants have been studied before, but no study has attempted a genome-scale investigation of the genetic opportunities for cheating. Here we describe such a screen in a social amoeba and show that cheating is multifaceted by revealing cheater mutations in well over 100 genes of diverse types. Many of these mutants cheat facultatively, producing more than their fair share of spores in chimaeras, but cooperating normally when clonal. These findings indicate that phenotypically stable cooperative systems may nevertheless harbour genetic conflicts. The opportunities for evolutionary moves and countermoves in such conflicts may select for the involvement of multiple pathways and numerous genes. 相似文献