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901.
Thomas H. Lee 《国外科技新书评介》2005,(6):18-19
本书是《10^9赫射频(RF)集成电路设计指南》修订后的第二版。自1998年第一版问世后,RFCMOS的商品化突飞猛进,不少公司用CMOS技术制造RF线路,大学也把CMOS作为教学内容,10^9赫频率上的噪声系数在实际线路中已低于1dB,优良的RF器件模型也相继出现……这些都为本书的适时修订提供了充分条件。 相似文献
902.
Alan Berkeley Thomas 《Systemic Practice and Action Research》1997,10(6):681-701
The aim of this paper is to explore the contention that Western Management Education has entered a period of “crisis” and
to examine the implications of such a development. Drawing on historical studies of management education in America and Europe,
four modes of management “formation” are identified, each of which has been dominant in a particular period. From its preparadigmatic
beginnings management education has been successively transformed under an “old” and latterly a “new” paradigm. Current changes
in and critiques of the “new” paradigm imply that Western Management Education is entering a postparadigmatic mode. The implications
of this postparadigmatic turn are considered in relation to management practice, management knowledge, and management “formation.”
An earlier version of this paper was presented to the Annual Conference of the British Academy of Management, Aston University,
Birmingham, September 16–18, 1996. 相似文献
903.
904.
Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers 总被引:1,自引:0,他引:1
Sarkar AK Luijten M Miyashima S Lenhard M Hashimoto T Nakajima K Scheres B Heidstra R Laux T 《Nature》2007,446(7137):811-814
Throughout the lifespan of a plant, which in some cases can last more than one thousand years, the stem cell niches in the root and shoot apical meristems provide cells for the formation of complete root and shoot systems, respectively. Both niches are superficially different and it has remained unclear whether common regulatory mechanisms exist. Here we address whether root and shoot meristems use related factors for stem cell maintenance. In the root niche the quiescent centre cells, surrounded by the stem cells, express the homeobox gene WOX5 (WUSCHEL-RELATED HOMEOBOX 5), a homologue of the WUSCHEL (WUS) gene that non-cell-autonomously maintains stem cells in the shoot meristem. Loss of WOX5 function in the root meristem stem cell niche causes terminal differentiation in distal stem cells and, redundantly with other regulators, also provokes differentiation of the proximal meristem. Conversely, gain of WOX5 function blocks differentiation of distal stem cell descendents that normally differentiate. Importantly, both WOX5 and WUS maintain stem cells in either a root or shoot context. Together, our data indicate that stem cell maintenance signalling in both meristems employs related regulators. 相似文献
905.
Korn T Bettelli E Gao W Awasthi A Jäger A Strom TB Oukka M Kuchroo VK 《Nature》2007,448(7152):484-487
On activation, naive T cells differentiate into effector T-cell subsets with specific cytokine phenotypes and specialized effector functions. Recently a subset of T cells, distinct from T helper (T(H))1 and T(H)2 cells, producing interleukin (IL)-17 (T(H)17) was defined and seems to have a crucial role in mediating autoimmunity and inducing tissue inflammation. We and others have shown that transforming growth factor (TGF)-beta and IL-6 together induce the differentiation of T(H)17 cells, in which IL-6 has a pivotal function in dictating whether T cells differentiate into Foxp3+ regulatory T cells (T(reg) cells) or T(H)17 cells. Whereas TGF-beta induces Foxp3 and generates T(reg) cells, IL-6 inhibits the generation of T(reg) cells and induces the production of IL-17, suggesting a reciprocal developmental pathway for T(H)17 and T(reg) cells. Here we show that IL-6-deficient (Il6-/-) mice do not develop a T(H)17 response and their peripheral repertoire is dominated by Foxp3+ T(reg) cells. However, deletion of T(reg) cells leads to the reappearance of T(H)17 cells in Il6-/- mice, suggesting an additional pathway by which T(H)17 cells might be generated in vivo. We show that an IL-2 cytokine family member, IL-21, cooperates with TGF-beta to induce T(H)17 cells in naive Il6-/- T cells and that IL-21-receptor-deficient T cells are defective in generating a T(H)17 response. 相似文献
906.
907.
908.
Cavalier-Smith T 《Nature》2007,446(7133):257
909.
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project 总被引:2,自引:0,他引:2
ENCODE Project Consortium Birney E Stamatoyannopoulos JA Dutta A Guigó R Gingeras TR Margulies EH Weng Z Snyder M Dermitzakis ET Thurman RE Kuehn MS Taylor CM Neph S Koch CM Asthana S Malhotra A Adzhubei I Greenbaum JA Andrews RM Flicek P Boyle PJ Cao H Carter NP Clelland GK Davis S Day N Dhami P Dillon SC Dorschner MO Fiegler H Giresi PG Goldy J Hawrylycz M Haydock A Humbert R James KD Johnson BE Johnson EM Frum TT Rosenzweig ER Karnani N Lee K Lefebvre GC Navas PA Neri F Parker SC Sabo PJ 《Nature》2007,447(7146):799-816
910.
Evans MJ von Hahn T Tscherne DM Syder AJ Panis M Wölk B Hatziioannou T McKeating JA Bieniasz PD Rice CM 《Nature》2007,446(7137):801-805
Hepatitis C virus (HCV) is a leading cause of cirrhosis and liver cancer worldwide. A better understanding of the viral life cycle, including the mechanisms of entry into host cells, is needed to identify novel therapeutic targets. Although HCV entry requires the CD81 co-receptor, and other host molecules have been implicated, at least one factor critical to this process remains unknown (reviewed in refs 1-3). Using an iterative expression cloning approach we identified claudin-1 (CLDN1), a tight junction component that is highly expressed in the liver, as essential for HCV entry. CLDN1 is required for HCV infection of human hepatoma cell lines and is the first factor to confer susceptibility to HCV when ectopically expressed in non-hepatic cells. Discrete residues within the first extracellular loop (EL1) of CLDN1, but not protein interaction motifs in intracellular domains, are critical for HCV entry. Moreover, antibodies directed against an epitope inserted in the CLDN1 EL1 block HCV infection. The kinetics of this inhibition indicate that CLDN1 acts late in the entry process, after virus binding and interaction with the HCV co-receptor CD81. With CLDN1 we have identified a novel key factor for HCV entry and a new target for antiviral drug development. 相似文献