Influence of operational parameters on the photocatalytic performance of DE-NOx process Via MIL-101(Fe)

Metal organic framework(MOF)has been paid great attention as a potential candidate for various applications in the field of energy and environment,particularly in air purification.Among various MOFs,MIL-101(Fe) represents an interesting material possessing many advantages,including the ease of fabrication,high porosity,high specific surface area with open metal sites,making it a promising material in the field of harmful gas treatment.Taking these advantages,MIL-101(Fe) was synthesized by facile microwave-solvothermal method and applied as a photocatalyst for the degradation of NO_x.The de-NO_x efficiency of the synthesized powder was evaluated with respect to various operating parameters including substrates,sample doses,light spectrum and light intensity,initial NO concentration,and relative humidity.The results have shown that the efficiency of NO_x photocatalytic degradation reaches to 77%under solar irradiation via 0.1 g of MIL-101(Fe) with optimum condition of reaction,(alumina substrate,350 ppb of initial NO concentration,40–50%of relative humidity).Then this work provides the optimum condition for the efficient photocatalytic degradation of NO_x.     

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca<Superscript>2+</Superscript> signalling

Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce invasivity of CRC. Understanding the mechanisms of metastatic CRC is crucial for successful intervention. Therefore, we studied pro-invasive contributions of stromal cells in physiologically relevant three-dimensional in vitro assays consisting of CRC spheroids, CAFs, extracellular matrix and endothelial cells, as well as in reductionist models. In order to elucidate how CAFs support CRC invasion, tumour spheroid-induced CAF retraction and free intracellular Ca²⁺ levels were measured and pharmacological- or siRNA-based inhibition of selected signalling cascades was performed. CRC spheroids caused the retraction of CAFs, generating entry gates in the adjacent surrogate stroma. The responsible trigger factor 12(S)-HETE provoked a signal, which was transduced by PLC, IP3, free intracellular Ca²⁺, Ca²⁺-calmodulin-kinase-II, RHO/ROCK and MYLK which led to the activation of myosin light chain 2, and subsequent CAF mobility. RHO activity was observed downstream as well as upstream of Ca²⁺ release. Thus, Ca²⁺ signalling served as central signal amplifier. Treatment with the FDA-approved drugs carbamazepine, cinnarizine, nifedipine and bepridil HCl, which reportedly interfere with cellular calcium availability, inhibited CAF-retraction. The elucidation of signalling pathways and identification of approved inhibitory drugs warrant development of intervention strategies targeting tumour–stroma interaction.     

语言死亡:语言的安全与不安全

语言的死亡,就是指一种语言在一个国家当前全球一体化和都市化两种社会因素影响下从安全到不安全的过程。从安全到不安全从而导致语言死亡是一段危机程度各不相同的距离,且语言的不安全不仅只对人口稀少的少数民族语言而言,也对人口众多的少数民族语言而言,甚至还可用于在当前全球一体化趋势下国家语言所面临的英语危机,以及在国家都市化趋势下方言所面临的消亡危机。     

Effects of gamma irradiation on dermal equivalents in vitro

Summary Dermal equivalents (DE), collagen lattices, were produced in vitro and used as a model for studying the possible role of a pure population of fibroblasts in post-radiotherapeutic dermal fibrosis. Single doses of gamma irradiation induced a partial inhibition of the collagen lattice retraction and of protein synthesis. The collagen production was less inhibited than was synthesis of non-collagen protein, which resulted in an increase of the relative amount of collagen synthesized by irradiated fibroblasts. These data suggest that gamma irradiation might be able to select some fibroblast clones able to produce increasing amounts of collagen. This selection process could be involved in the development of tissue fibrosis after therapeutic radiation.     

Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population

Leprosy, a chronic infectious disease caused by Mycobacterium leprae, affects an estimated 700,000 persons each year. Clinically, leprosy can be categorized as paucibacillary or multibacillary disease. These clinical forms develop in persons that are intrinsically susceptible to leprosy per se, that is, leprosy independent of its specific clinical manifestation. We report here on a genome-wide search for loci controlling susceptibility to leprosy per se in a panel of 86 families including 205 siblings affected with leprosy from Southern Vietnam. Using model-free linkage analysis, we found significant evidence for a susceptibility gene on chromosome region 6q25 (maximum likelihood binomial (MLB) lod score 4.31; P = 5 x 10(-6)). We confirmed this by family-based association analysis in an independent panel of 208 Vietnamese leprosy simplex families. Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively).     

Functional study of cultured bone cells]

Osseous cells in culture synthesize and excrete glycosaminoglycans, collagen and alkaline phosphatases, revealed by the classical histochemical reactions. Observation of the living cells iwth the polarizing microscope, after a five day-culture, reveals the presence of micro-crystals of mineral salts only at the level of cells and cellular groupings.