Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology

Neurofibromatosis type 2 is an autosomal dominant disorder characterized by tumors, predominantly schwannomas, in the nervous system. It is caused by mutations in the gene NF2, encoding the growth regulator schwannomin (also known as merlin). Mutations occur throughout the 17-exon gene, with most resulting in protein truncation and undetectable amounts of schwannomin protein. Pathogenic mutations that result in production of defective schwannomin include in-frame deletions of exon 2 and three independent missense mutations within this same exon. Mice with conditional deletion of exon 2 in Schwann cells develop schwannomas, which confirms the crucial nature of exon 2 for growth control. Here we report that the molecular adaptor paxillin binds directly to schwannomin at residues 50-70, which are encoded by exon 2. This interaction mediates the membrane localization of schwannomin to the plasma membrane, where it associates with beta 1 integrin and erbB2. It defines a pathogenic mechanism for the development of NF2 in humans with mutations in exon 2 of NF2.     

The prolactin releasing peptides: RF-amide peptides

Although dopamine is considered the major hypothalamic controller of prolactin release from the anterior pituitary gland, there is evidence that a yet to be discovered prolactin releasing factor (PRF) also exists in brain. Recently, two peptides were isolated, products of the same prohormone, that were reported to have significant prolactin-releasing activity. These peptides, called prolactin releasing peptides, are not accepted by all investigators to be in fact PRFs. Instead, it appears that their widespread distribution in brain and the presence of receptors for the peptides in sites unrelated to neuroendocrine function are the basis for a variety of central nervous system action including activation of the autonomic nervous system. Thus, these peptides may not be PRFs, but instead neuroactive agents that are involved in many brain circuits with divergent functions.     

我国海洋主题公园的发展阶段及其特征

通过网络、书籍、学术期刊及实地考察等渠道,共搜集了55家海洋主题公园的详细资料进行分析,从中获得了国内海洋主题公园发展的总体概况;对国内海洋主题公园的发展历程进行回顾,归纳并阐述了其不同发展阶段所表现出的主要特征,总结了海洋主题公园发展的生命周期规律及经验教训,以期为已经运营或拟建的海洋主题公园提供借鉴.     

Synopsis of ‘onychocellid’ cheilostome bryozoan genera

Genera assigned to the cheilostome bryozoan family Onychocellidae are revised based on the skeletal morphology of the type species and, when possible, the type material of these species. All genera are illustrated using scanning electron micrographs, some for the first time. Onychocellidae, which ranges from the Cenomanian stage of the Cretaceous to the Recent, has been a particularly troublesome family because of poorly defined generic concepts correlating at least in part with a paucity of morphological characters. Thirty-five genera are described in this review. Of these, two are recognised as subjective synonyms of other onychocellid genera (Rhebasia and Semieschara), one cannot be sufficiently characterised from the type material (Collura), and two are new: Aechmellina gen. nov. (type species Aechmella falcifera) and Kamilocella gen. nov. (type species Eschara latilabris). A neotype is chosen for Rhagasostoma hexagonum, the type species of Rhagasostoma. A key is provided to assist in the identification of onychocellid genera. Phylogenetic relationships between genera remain obscure and are unlikely to be fully resolved based on skeletal morphology alone. The family as an entity is loosely circumscribed and almost certainly paraphyletic, containing stem genera of other anascan familes such as Lunulitidae, Coscinopleuridae and Aspidostomatidae.

www.zoobank.org/urn:lsid:org:pub:63A31AD2-F049-42CB-A45B-557014DC286E     

面向大一学生的工程实践类课程的重要性研究

"卓越工程师教育培养计划"的提出,为高等工程教育工程技术人才的培养提出了更高的要求。基于卓越工程师培养目标,学生刚进入大学的最初阶段必须打好基础,为后续的学习和提高做准备。从大一学生工程素质现状调查入手,分析大一学生现状,阐明针对大一学生开设工程实践类课程的必要性,同时对这类面对大学新生的"导引式"工程实践课程的教学目标及其在学生工程能力培养过程中的重要作用进行分析研究。     

Fibronectin peptide DRVPHSRNSIT and fibronectin receptor peptide DLYYLMDL arrest gastrulation ofRana pipiens

Gastrulation is characterized by dramatic cell migration which is thought to require the interaction of cell adhesion molecules with extracellular molecules. We have tested two novel peptides, a fibronectin peptide and a fibronectin receptor peptide, for their effects on gastrulation of the leopard frogRana pipiens. The fibronectin peptide DRVPHSRNSIT corresponds to residues 1373–1383 of the cell-binding domain of fibronectin; the receptor peptide DLYYLMDL corresponds to residues 124–131 of 1 subunit of a variety of integrins including 51. Either of these peptides significantly inhibited gastrulation after being microinjected into mid-blastulae. These results indicate that these sequences may correspond to the ligand/receptor interaction sites of fibronectin and its receptor(s).     

战后韩国高等教育大众化与普及化动力透析

战后韩国仅经历了30年便顺利完成了高等教育大众化与普及化任务。透析韩国高等教育发展历程,不难看出政策因素和经济因素是促使韩国高等教育健康快速发展的根源推动力。以历史为纬度,将定性分析与定量分析相结合探索韩国政策、经济因素对高等教育发展的作用,以期为我国高等教育的发展提供参考借鉴。     

The Theory and Evaluation Method of the Sustainable Development System About the Harmonious Growth of Population, Resource, Environment and Economy in the County District of China

The linchpin of strategy about the Sustainable Development (SD) in Chinese county enforcement area is to accomplish the basic transformation about the mode of economic development from extensive mode to intensive mode. For most counties of China, the overmany population is an element which influences the Sustainable Development. But to achieve the Sustainable Development based on the harmonious development of population, resource, economy and environment, the most important thing is how to carry on its management and evaluation method under the guide of the Tenth Five-Year Plan of national economy and the Perspective Target of 2010. Therefore ,this paper aims at reforming the traditional judging method focusing on output value-Income and establishing a systematic management method and evaluation index system about the sustainable development based on the harmonious growth of population,resource, economy and environment.