预应力混凝土结构孔道摩擦系数κ和μ值实测分析

文章通过预应力混凝土梁实测数据并参考了国内外的相关研究资料。对预应力束的孔道摩擦系数κ和μ值进行了较深入的分析。对影响摩擦系数的因素进行了探讨,认为我国规范取值偏小,文章给出了实际摩擦系数取值的建议。     

Experimental studies on oxidizing removal of Cyclops of zooplankton

0 IntroductionCyclops couldn’t be effectively inactivated by theconventional disinfection such as chlorination due to itsstronger resistance to oxidation.In addition,the motilityof Cyclops makes it easily penetrate sand filter into theclean water tank in waterworks , even municipal servicepipe .Adult Cyclops , with body length of one to severalmillimeters, may be caught by naked eye to bring con-sumers unsanitary sense and may become disease trans-mission mediumas the host of pathogenic para…     

Application of meshless method to electromagnetic NDT

0 Introduction Finite element methods have been successfully pliedfor solving different kinds of problemsinelectrom netic NDT. The domain under study is divided into mesh of element inthis method.For complicated geom tries or in variable geometry problemsthe mesh present high computational cost due to the reevaluation of e newgeometry. Meshless methods are nowproven as a robust te nique to study field problems in which large geometri deformations areto be modeled,since such methods av the on…     

Genome-wide association studies of 14 agronomic traits in rice landraces

Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified ～ 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained ～ 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice.     

Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

外源性H2S通过调节β-位淀粉样前体蛋白裂解酶1表达对PC12细胞APP／Aβ代谢的影响

目的观察外源性硫化氢对嗜铬细胞瘤细胞β-位淀粉样前体蛋白裂解酶1（BACE1）的调节作用,进而探讨其对淀粉样前体蛋白／β-位淀粉样蛋白代谢途径的影响。方法用硫氢化钠作外源性H2s供体,实验设空白对照组、NaHs50μmol／L组、NaHS100μmol／L组和NariS200μmol／L组,按分组浓度处理PC12细胞24h后,RT-PCR和Western blot法检测细胞内BACE1 mRNA及蛋白表达,并用Western blot法继而检测APP代谢过程中关键蛋白APP、C99、C83表达变化,EusA法检测细胞培养液中AB40和AB42水平。结果NaHS在实验浓度范围内从基因与蛋白两个水平上呈剂量依赖性下调BACE1表达,并下调C99、Ap40和Ap42蛋白表达,上调C83蛋白,各NaHS组分别与对照组比较,差别均有统计学意义（P〈0．05）,而对APP蛋白表达没有影响,各组间比较差别无显著性（P〉0．05）。结论外源性H2s具有通过调节PC12细胞BACE1表达下调APP／Aβ代谢的作用。     

离心压缩机的扩压器内部流场分析及其结构优化

首先对等宽型无叶扩压器内部流动情况进行了较为详细的分析,在此分析基础上进行了两处改进：1）将等宽型无叶扩压器改为收缩型无叶扩压器;2）在原等宽无叶扩压器中加装导向叶片,并利用CFD软件（FLUENT）对改进后的扩压器内部流场进行数值模拟。从模拟结果上看：改进后的扩压器其内部流动不均匀情况得到明显改善,拥有了良好的气动性,从而有效地提高了压缩机整体性能。     

金属矿床和油气藏:沉积盆地中的两个亲兄弟

越来越多的证据揭示,沉积盆地中的很多金属矿床之中及附近发现有油气显示和沥青残斑,甚至油气藏。沉积盆地中的大多数金属矿床的流体包裹体中检测到甲烷和乙烷等有机气体,甚至一些矿床包裹体中还检测出原油。反过来,在很多油田的原油中也发现高含量金属元素。然而,长期以来,大多数研究者对沉积盆地金属矿床或者油气藏的研究是孤立进行的。文章对沉积盆地中金属矿床与油气藏这两个看似风马牛不相及的地质体进行了空间关系、物质关系和时间关系的分析,结果认为盆地中上述地质体的形成是对统一地质事件的响应,即在构造应力或者岩石静压力驱动下,成矿流体和油气向沉积盆地的隆起以及其他有利部位运移并成藏成矿。该认识对沉积盆地中金属矿床和油气藏的勘查也有指导意义。     

基于BP-AsymBoost的医疗诊断模型

本文主要研究BP神经网络以及AdaBoost算法在医疗诊断中的应用,在分析标准AdaBoost算法的基础上提出改进的AdaBoost算法,即BP-AsymBoost.针对UCI数据库中的威斯康星乳腺癌数据集设计结合BP网络以及改进后的AdaBoost算法的诊断模型,并且通过多个指标将其与BP模型,遗传算法优化的BP模型,未经改进的BP-AdaBoost模型进行比较,验证BP-AsymBoost模型的有效性.