高校图书馆文化活动中心建设构想

阐述了高校图书馆建设文化活动中心的意义和作用,分析了目前建设文化活动中心遇到的困境,并提出了解决困难的相应对策。     

基于计算实验的流感大流行预防策略

流感是人类健康的重大威胁之一.为探索预防新型流感大流行的有效策略,建立了北京市计算流行病模型,评估了边境口岸检疫,病例治疗,病例隔离,社会关系抗病毒预防以及免疫接种措施对四种新型流感大流行的预防效能.结果表明:边境口岸检疫对于预防新型流感大流行的作用非常有限;积极的病例治疗可预防传播能力类似于2009年A(H1N1)的新型流感大流行;高强度的病例治疗和病例隔离可预防传播能力类似于1957年A(H2N2)的新型流感大流行;对于传播能力类似于1918年A(H1N1)的新型流感,在高强度病例治疗和病例隔离的基础上须对病例的社会关系进行抗病毒预防才有可能预防大流行;而对于具有超级传播能力的新型流感(R_03.3),必须依靠有效的广谱疫苗才能预防大流行.研究结果对于进一步完善我国应对流感大流行的应急准备与处置计划具有参考价值.     

Modeling eBay price using stochastic differential equations

Online auctions have become increasingly popular in recent years. There is a growing body of research on this topic, whereas modeling online auction price curves constitutes one of the most interesting problems. Most research treats price curves as deterministic functions, which ignores the random effects of external and internal factors. To account for the randomness, a more realistic model using stochastic differential equations is proposed in this paper. The online auction price is modeled by a stochastic differential equation in which the deterministic part is equivalent to the second‐order differential equation model proposed in Wang et al. (Journal of the American Statistical Association, 2008, 103, 1100–1118). The model also includes a component representing the measurement errors. Explicit expressions for the likelihood function are also obtained, from which statistical inference can be conducted. Forecast accuracy of the proposed model is compared with the ODE (ordinary differential equation) approach. Simulation results show that the proposed model performs better.     

Aristotle Said “Happiness is a State of Activity” — Predicting Mood Through Body Sensing with Smartwatches

We measure and predict states of Activation and Happiness using a body sensing application connected to smartwatches. Through the sensors of commercially available smartwatches we collect individual mood states and correlate them with body sensing data such as acceleration, heart rate, light level data, and location, through the GPS sensor built into the smartphone connected to the smartwatch. We polled users on the smartwatch for seven weeks four times per day asking for their mood state. We found that both Happiness and Activation are negatively correlated with heart beats and with the levels of light. People tend to be happier when they are moving more intensely and are feeling less activated during weekends. We also found that people with a lower Conscientiousness and Neuroticism and higher Agreeableness tend to be happy more frequently. In addition, more Activation can be predicted by lower Openness to experience and higher Agreeableness and Conscientiousness. Lastly, we find that tracking people’s geographical coordinates might play an important role in predicting Happiness and Activation. The methodology we propose is a first step towards building an automated mood tracking system, to be used for better teamwork and in combination with social network analysis studies.     

Early SIV and HIV infection promotes the LILRB2/MHC-I inhibitory axis in cDCs

Classical dendritic cells (cDCs) play a pivotal role in the early events that tip the immune response toward persistence or viral control. In vitro studies indicate that HIV infection induces the dysregulation of cDCs through binding of the LILRB2 inhibitory receptor to its MHC-I ligands and the strength of this interaction was proposed to drive disease progression. However, the dynamics of the LILRB2/MHC-I inhibitory axis in cDCs during early immune responses against HIV are yet unknown. Here, we show that early HIV-1 infection induces a strong and simultaneous increase of LILRB2 and MHC-I expression on the surface of blood cDCs. We further characterized the early dynamics of LILRB2 and MHC-I expression by showing that SIVmac251 infection of macaques promotes coordinated up-regulation of LILRB2 and MHC-I on cDCs and monocytes/macrophages, from blood and lymph nodes. Orientation towards the LILRB2/MHC-I inhibitory axis starts from the first days of infection and is transiently induced in the entire cDC population in acute phase. Analysis of the factors involved indicates that HIV-1 replication, TLR7/8 triggering, and treatment by IL-10 or type I IFNs increase LILRB2 expression. Finally, enhancement of the LILRB2/MHC-I inhibitory axis is specific to HIV-1 and SIVmac251 infections, as expression of LILRB2 on cDCs decreased in naturally controlled chikungunya virus infection of macaques. Altogether, our data reveal a unique up-regulation of LILRB2 and its MHC-I ligands on cDCs in the early phase of SIV/HIV infection, which may account for immune dysregulation at a critical stage of the anti-viral response.     

基于小波分析对地面电场信号的去噪及闪电信息提取

基于小波分析方法,通过对7种小波函数在误差控制和阈值方法选取上的对比,参考信噪比及均方误差等计算结果,选取了较为合理的Rigrsure阈值分析方法和sym5小波函数作为地面大气电场信号的去噪处理方法.该方法不仅能够较好地对电场信号波形平滑处理,降低电场波形中噪声信号的叠加度,还可保留闪电引起的电场的快速变化.在此基础上,利用差分计算方法实现了对闪电信号的自动识别,引入了总闪电频数误差及分时段闪电频数与人工分析结果的相关系数等2个参考量来选取差分计算方法中电场差分阈值,通过该方法可以实现闪电频数和极性等有关信息的提取.     

Notch Effect and Frequency Compensation of Dual-Sensor OBC Data in Shallow Water

Reverberation is significant in shallow water and produces obvious notches in OBC spec-tra. It also degrades the quality of sections and increases the difficulty of processing and interpretation. This ...     

河南农业科技创新联盟建设与发展的思考

农业科技创新联盟是联盟发展的新产物,是农业科技创新进行协作的组织形式。本文主要通过对农业科技创新联盟及其重要作用和农业科技创新联盟功能定位、管理体制与存在问题进行了分析论述,提出了河南农业科技创新联盟建设发展的对策建议