安全性第一准则下的组合贷款模型

提出了一种在概率准则意义下的组合贷款模型,并设计了基于随机模拟的混合优化算法进行求解。 该算法突破了各种贷款收益率必须服从正态分布的假定,可对贷款收益率是任意分布形式的模型进行求解。 经数值仿真,验证了算法的可行性。     

滚压对6061铝合金微动磨损性能的影响

应用一种恒力式滚压工具,依据Box-Behnken中心组合设计原理,以车削进给量、滚压力和滚压次数为自变量,以在SRV IV实验机上实现的100℃下的无润滑条件和润滑条件下的微动磨损体积为响应值,对6061铝合金进行滚压后的微动实验,推导出了非平面微动磨损体积的计算公式,并对微动实验中的摩擦系数、试样初始表面粗糙度和磨...     

高职院校旅游英语专业国际化实用型人才培养研究

旅游英语专业国际化实用型人才培养研究目的是通过对国内外旅游企业人才需求标准的调研,确立了旅游英语专业人才培养的核心能力,通过构建课程体系和实践教学体系,改革课堂教学方法,培养国际化双师素质师资队伍,建设校内外实训基地等措施,完善旅游英语专业的人才培养模式,达到人才培养与市场需求接轨的目标,提高高职院校旅游英语专业人才培养水平.     

均匀棒纯纵向运动初值问题混合有限元方法的H(div)模误差估计

笔者继续考虑均匀棒纯纵向运动初值问题的混合有限元方法[1],利用广义混合椭圆投影的误差估计,给出了H(div)模最优误差估计,使得该问题得到进一步的解决.     

职前小学科学教师的专业发展

职前小学科学教师专业发展是教师终身专业发展的基础阶段。为了促进职前小学科学教师专业发展,提出改革与职前小学科学教师专业发展不适应的课程设置,培养职前小学科学教师自主专业发展意识,加强教育实践和教育研究,从而加速职前小学科学教师的成长和发展。     

浅谈变电站自动化系统调试

文章从变电站现场调试工作前的准备到设备投运的整个工作程序和调试方法及注意事项进行了详细介绍,并说明了细节问题应注意的事项。     

电梯安全钳检验及常见故障问题分析

文章在论述安全钳装置原理的基础上,探讨安全钳的检验检测重点,并就安全钳常见故障问题进行了分析,提出解决措施,最后结合实例,具体分析某电梯安全钳误动作故障及解决办法.     

GPON技术在网络中的应用

文章详细描述了GPON技术的组成、特点、应用模式及组网方案,并通过工程案例介绍了GPON在接入网中的应用。     

浅谈协同商务对会计信息化的影响

协同商务对会计信息化提出了新的挑战。文章探讨了协同商务的含义,并在此基础上归纳了协同商务对会计信息化的影响。     

Programming the magnitude and persistence of antibody responses with innate immunity

Many successful vaccines induce persistent antibody responses that can last a lifetime. The mechanisms by which they do so remain unclear, but emerging evidence indicates that they activate dendritic cells via Toll-like receptors (TLRs). For example, the yellow fever vaccine YF-17D, one of the most successful empiric vaccines ever developed, activates dendritic cells via multiple TLRs to stimulate proinflammatory cytokines. Triggering specific combinations of TLRs in dendritic cells can induce synergistic production of cytokines, which results in enhanced T-cell responses, but its impact on antibody responses remain unknown. Learning the critical parameters of innate immunity that program such antibody responses remains a major challenge in vaccinology. Here we demonstrate that immunization of mice with synthetic nanoparticles containing antigens plus ligands that signal through TLR4 and TLR7 induces synergistic increases in antigen-specific, neutralizing antibodies compared to immunization with nanoparticles containing antigens plus a single TLR ligand. Consistent with this there was enhanced persistence of germinal centres and of plasma-cell responses, which persisted in the lymph nodes for >1.5 years. Surprisingly, there was no enhancement of the early short-lived plasma-cell response relative to that observed with single TLR ligands. Molecular profiling of activated B cells, isolated 7 days after immunization, indicated that there was early programming towards B-cell memory. Antibody responses were dependent on direct triggering of both TLRs on B cells and dendritic cells, as well as on T-cell help. Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques.