Optimal design and experiment research of an orthogonal-parallel six-axis force/torque sensor

A novel orthogonal-parallel six-axis force/torque sensor is studied based on a modified Stewart platform architecture,and the optimal design and experiment rese...     

大跨公轨合建斜拉桥主‒引桥地震相对位移响应与控制

基于巴拿马运河四桥研究了公轨合建斜拉桥在地震下的主-引桥相对位移响应与控制问题,分别建立了漂浮抗震设计方案、仅塔梁固结方案和固结方案有限元分析模型,分析了三种约束方案的相对位移响应。基于单自由度振子研究了相邻结构周期比和阻尼特性对结构相邻位移的影响。结合理论与参数分析,研究了主-引桥相对位移的控制方法。结果显示:主、引桥纵向首阶振型周期比、等效阻尼比之比以及阻尼机制对相邻结构的相对位移影响显著,其中周期比对相对位移的影响最为显著。不同粘滞阻尼器布置方案对主-引桥梁端相对位移的减震效果不同,直接在主、引桥梁-梁之间设置粘滞阻尼器有助于改善主桥与引桥梁端位移的同步性,控制效果最好;同时在主桥各墩位处和主、引桥梁-梁之间设置阻尼器的减震效果次之,但易于设计和安装,适应性好。     

Incorporating textual and management factors into financial distress prediction: A comparative study of machine learning methods

Financial distress prediction (FDP) has been widely considered as a promising approach to reducing financial losses. While financial information comprises the traditional factors involved in FDP, nonfinancial factors have also been examined in recent studies. In light of this, the purpose of this study is to explore the integrated factors and multiple models that can improve the predictive performance of FDP models. This study proposes an FDP framework to reveal the financial distress features of listed Chinese companies, incorporating financial, management, and textual factors, and evaluating the prediction performance of multiple models in different time spans. To develop this framework, this study employs the wrapper-based feature selection method to extract valuable features, and then constructs multiple single classifiers, ensemble classifiers, and deep learning models in order to predict financial distress. The experiment results indicate that management and textual factors can supplement traditional financial factors in FDP, especially textual ones. This study also discovers that integrated factors collected 4 years prior to the predicted benchmark year enable a more accurate prediction, and the ensemble classifiers and deep learning models developed can achieve satisfactory FDP performance. This study makes a novel contribution as it expands the predictive factors of financial distress and provides new findings that can have important implications for providing early warning signals of financial risk.     

接种密度对Vero细胞在微载体表面生长的影响

研究了接种密度对Ｖｅｒｏ细胞在微载体表面生长行为的影响,发现培养过程中所获得的细胞最高密度随接种密度的增加而有所提高,当细胞的表面接种密度高于１．０×１０＾５ｃｅｌｌｓ／ｍｇＭＣ时,因贴壁后细胞扩展受到限制而不利于进入对数生长期。就整个Ｖｅｒｏ细胞培养过程,适宜的表面接种密度为３×１０＾－４－７×１０＾４ｃｅｌｌｓ／ｍｇＭＣ,此时可以获得较高的比生长速率和细胞增殖倍数。     

脱硫催化剂的酸法制备及性能研究

对用酸法进行催化剂制备，酸法制备的最佳镁铝比，分散介质的优化，引入对脱催化剂的氧化性能和还原性能的影响。以及实验室的还原温度等诸方面进行了研究。     

Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis

When they recognize a target cell, natural killer (NK) cells mount an attack to kill the target by exerting their cytotoxicity via the exocytosis of cytotoxic granules. Although the details of this process (which includes the movement of cytotoxic granules in the immune synapse and their fusion with the plasma membrane, releasing granzymes and perforin into the synaptic cleft) are relatively better understood, the post-exocytosis regulation of the process is still largely unknown. Here we show that a clathrin-dependent endocytosis stimulated by target cell occurs in NK92 cell line, which is closely correlated with granzyme B recovery. Inhibition of the endocytosis significantly attenuates the cytotoxicity of NK92 cells. The NK cell recovery of its released effector molecules, in turn, suggests that endocytosis may well play a key role in the post exocytosis regulation of immune cells.     

Exome sequencing of liver fluke-associated cholangiocarcinoma

Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O. viverrini-related tumors and matched normal tissue. We identified and validated 206 somatic mutations in 187 genes using Sanger sequencing and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA (cases). In addition to the known cancer-related genes TP53 (mutated in 44.4% of cases), KRAS (16.7%) and SMAD4 (16.7%), we identified somatic mutations in 10 newly implicated genes in 14.8-3.7% of cases. These included inactivating mutations in MLL3 (in 14.8% of cases), ROBO2 (9.3%), RNF43 (9.3%) and PEG3 (5.6%), and activating mutations in the GNAS oncogene (9.3%). These genes have functions that can be broadly grouped into three biological classes: (i) deactivation of histone modifiers, (ii) activation of G protein signaling and (iii) loss of genome stability. This study provides insight into the mutational landscape contributing to O. viverrini-related CCA.     

基于几何统计的无人机信道模型及硬件模拟

针对无人机(unmanned aerial vehicle, UAV)通信信号三维空间传播特点,提出了基于多圆柱体的非平稳几何统计模型(geometry-based stochastic channel model, GSCM),该模型通过引入天线位置变换矩阵,可支持UAV〖JP2〗和地面移动端(mobile terminal,MT)任意三维移动轨迹。在此基础上,构建了适合硬件模拟实现的离散化模型,并设计实现了模拟时变信道特性的随机簇生灭算法,以及基于线性调频叠加原理的非平稳衰落模拟方法。硬件实测结果表明,本文信道模拟器输出的衰落幅值分布、时延功率谱和多普勒功率谱等统计特性与理论结果比较吻合,有效复现了信道时变衰落、多径时延、多径功率和多普勒频率随着UAV的位置和速度变化而变化的过程。     

基于ADCensus的改进半全局匹配方法

考虑到AD相似性测度对灰度信息及纹理丰富的区域的优势和Census变换对图像辐射差异具有鲁棒性的优势,将AD和Census算法融合替代单一匹配代价来改进半全局密集匹配算法,可有效提高算法的匹配精度和抗干扰性。同时用金字塔分层匹配策略来约束视差的搜索范围,实验结果表明,该方法在保证匹配精度的同时,减少内存消耗和运行时间,适用于无人机影像的密集匹配。