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171.
Ong CK Subimerb C Pairojkul C Wongkham S Cutcutache I Yu W McPherson JR Allen GE Ng CC Wong BH Myint SS Rajasegaran V Heng HL Gan A Zang ZJ Wu Y Wu J Lee MH Huang D Ong P Chan-on W Cao Y Qian CN Lim KH Ooi A Dykema K Furge K Kukongviriyapan V Sripa B Wongkham C Yongvanit P Futreal PA Bhudhisawasdi V Rozen S Tan P Teh BT 《Nature genetics》2012,44(6):690-693
Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O. viverrini-related tumors and matched normal tissue. We identified and validated 206 somatic mutations in 187 genes using Sanger sequencing and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA (cases). In addition to the known cancer-related genes TP53 (mutated in 44.4% of cases), KRAS (16.7%) and SMAD4 (16.7%), we identified somatic mutations in 10 newly implicated genes in 14.8-3.7% of cases. These included inactivating mutations in MLL3 (in 14.8% of cases), ROBO2 (9.3%), RNF43 (9.3%) and PEG3 (5.6%), and activating mutations in the GNAS oncogene (9.3%). These genes have functions that can be broadly grouped into three biological classes: (i) deactivation of histone modifiers, (ii) activation of G protein signaling and (iii) loss of genome stability. This study provides insight into the mutational landscape contributing to O. viverrini-related CCA. 相似文献
172.
A rare penetrant mutation in CFH confers high risk of age-related macular degeneration 总被引:1,自引:0,他引:1
173.
Tan L Li X Liu F Sun X Li C Zhu Z Fu Y Cai H Wang X Xie D Sun C 《Nature genetics》2008,40(11):1360-1364
The transition from the prostrate growth of ancestral wild rice (O. rufipogon Griff.) to the erect growth of Oryza sativa cultivars was one of the most critical events in rice domestication. This evolutionary step importantly improved plant architecture and increased grain yield. Here we find that prostrate growth of wild rice from Yuanjiang County in China is controlled by a semi-dominant gene, PROG1 (PROSTRATE GROWTH 1), on chromosome 7 that encodes a single Cys(2)-His(2) zinc-finger protein. prog1 variants identified in O. sativa disrupt the prog1 function and inactivate prog1 expression, leading to erect growth, greater grain number and higher grain yield in cultivated rice. Sequence comparison shows that 182 varieties of cultivated rice, including 87 indica and 95 japonica cultivars from 17 countries, carry identical mutations in the prog1 coding region that may have become fixed during rice domestication. 相似文献
174.
用大时宽带宽信号是提高雷达距离、速度及其联合分辨性能的最常用方法之一。频率编码脉冲是一种大时宽带信号,具有良好的距离分辨性能和较窄的瞬时带宽。推导了频率编码脉冲信号及步进频率脉冲信号的模糊函数,分析了其距离、速度分辨性能及其相应关系,并就有效解决其距离-速度联合测量问题进行了讨论。 相似文献
175.
Traditional processes for treating vanadium slag generate a huge volume of solid residue and a large amount of harmful gas, which cause serious environmental problems. In this study, a new process for the comprehensive utilization of vanadium slag was proposed, wherein zeolite A and a V2O5/TiO2 system were synthesized. The structural properties of the as-synthesized zeolite A and the V2O5/TiO2 system were characterized using various experimental techniques, including X-ray diffraction, X-ray fluorescence, scanning electron microscopy, and infrared spectroscopy. The results reveal that zeolite A and the V2O5/TiO2 system are successfully obtained with high purity. The results of gas adsorption measurements indicate that the prepared zeolite A exhibits high selectivity for CO2 over N2 and is a candidate material for CO2 capture from flue-gas streams. 相似文献
176.
根据当前就业形势对以实践性、应用性为主要特色的新闻传播学专业人才的要求,在分析高校专业实践教学存在的问题的基础上,提出高校新闻传播学专业实践教学应加强新闻传播学专业实践教学的规划,创新实践教学的模式,完善专业实践教学基地的建设。 相似文献
177.
178.
长期以来隧道衬砌水压力问题,一直是人们争论的焦点。依托宜万铁路岩溶隧道工程,对不同防排水方式(即全封堵、堵排结合及排放方式)的隧道衬砌水压力分布规律进行研究,研究方法主要采用模型试验及现场测试方法,模型试验的比例尺为1∶16,试验台架可同时施加土压和水压。通过模型试验得出水压力分布规律:全封堵条件下衬砌背后水压力不能折减,注浆圈也不能有效减小水压力;隧道内排水后衬砌背后水压力明显减小,并随着排水量的增加,水压力基本成直线下降;相同排水量时,注浆效果越好,衬砌背后水压力减小越明显;隧道采用全排导方式时,衬砌仍承受一定的水压。由模型试验得出的水压分布规律的部分结论,在现场水压力测试中得到了验证。 相似文献
179.
Sheng-jun Li Yuan Lin Wei-wei Tan Jing-bo Zhang Xiao-wen Zhou Jin-mao Chen Zeng Chen 《矿物冶金与材料学报》2010,17(1):92-97
The ZnO-modified TiO2 electrode was prepared by adding Zn(CH3COO)2·2H2O to the TiO2 colloid during the sol-gel production process, and was used in dye-sensitized solar cells (DSCs). The open circuit voltage
(V
OC) and fill factor (ff) of the cells were improved significantly. The performances of the ZnO-modified TiO2 electrode such as dark current, transient photocurrent, impedance, absorption spectra, and flat band potential (V
fb) were investigated. It is found that the interface charge recombination impedance increases and V
fb shifts about 200 mV toward the cathodic potential. The effect mechanism of ZnO modification on the performance of DSCs may
be that ZnO occupies the surface states of the TiO2 film. 相似文献
180.
要使我国从文化大国成为文化强国,从经济大国成为经济强国,必须着力构建中华主流文化,提升文化软实力。其途径一是要正确认识中华主流文化在软实力建设中的核心地位,二是要发挥好文化软实力的积极作用。 相似文献