Exome sequencing of liver fluke-associated cholangiocarcinoma

Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O. viverrini-related tumors and matched normal tissue. We identified and validated 206 somatic mutations in 187 genes using Sanger sequencing and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA (cases). In addition to the known cancer-related genes TP53 (mutated in 44.4% of cases), KRAS (16.7%) and SMAD4 (16.7%), we identified somatic mutations in 10 newly implicated genes in 14.8-3.7% of cases. These included inactivating mutations in MLL3 (in 14.8% of cases), ROBO2 (9.3%), RNF43 (9.3%) and PEG3 (5.6%), and activating mutations in the GNAS oncogene (9.3%). These genes have functions that can be broadly grouped into three biological classes: (i) deactivation of histone modifiers, (ii) activation of G protein signaling and (iii) loss of genome stability. This study provides insight into the mutational landscape contributing to O. viverrini-related CCA.     

武汉市"十一五"规划战略环境评价实践

以武汉市"十一五"规划战略环境评价为例,探讨了我国城市国民经济和社会发展规划战略环境评价的技术路线、指标体系与评价方法.研究表明,对城市空间布局、产业布局、产业结构以及城市交通的环境适宜性进行综合评价是这类规划战略环境评价的重要特征;互动式的评价模式能使环境因素及时、有效地纳入到决策过程中;指标体系是预测评价的基础,指标的选择除考虑科学性、代表性外还应强调可获得性、可量化性及可考核性.     

A novel process for comprehensive utilization of vanadium slag

Traditional processes for treating vanadium slag generate a huge volume of solid residue and a large amount of harmful gas, which cause serious environmental problems. In this study, a new process for the comprehensive utilization of vanadium slag was proposed, wherein zeolite A and a V₂O₅/TiO₂ system were synthesized. The structural properties of the as-synthesized zeolite A and the V₂O₅/TiO₂ system were characterized using various experimental techniques, including X-ray diffraction, X-ray fluorescence, scanning electron microscopy, and infrared spectroscopy. The results reveal that zeolite A and the V₂O₅/TiO₂ system are successfully obtained with high purity. The results of gas adsorption measurements indicate that the prepared zeolite A exhibits high selectivity for CO₂ over N₂ and is a candidate material for CO₂ capture from flue-gas streams.     

就业导向下高校新闻传播学实践教学的思考

根据当前就业形势对以实践性、应用性为主要特色的新闻传播学专业人才的要求，在分析高校专业实践教学存在的问题的基础上，提出高校新闻传播学专业实践教学应加强新闻传播学专业实践教学的规划，创新实践教学的模式，完善专业实践教学基地的建设。     

三生教育对大学生就业的影响

生命教育、生存教育、生活教育通过整合学校教育、家庭教育、社会教育的力量,激发学生的主体认知和行为实践,本文通过对生命教育、生存教育、生活教育内涵及其意义的探析,提出三生教育的实施必将推进大学生就业工作的顺利开展.     

岩溶隧道衬砌水压力分布规律研究

长期以来隧道衬砌水压力问题，一直是人们争论的焦点。依托宜万铁路岩溶隧道工程，对不同防排水方式（即全封堵、堵排结合及排放方式）的隧道衬砌水压力分布规律进行研究，研究方法主要采用模型试验及现场测试方法，模型试验的比例尺为1∶16，试验台架可同时施加土压和水压。通过模型试验得出水压力分布规律：全封堵条件下衬砌背后水压力不能折减，注浆圈也不能有效减小水压力；隧道内排水后衬砌背后水压力明显减小，并随着排水量的增加，水压力基本成直线下降；相同排水量时，注浆效果越好，衬砌背后水压力减小越明显；隧道采用全排导方式时，衬砌仍承受一定的水压。由模型试验得出的水压分布规律的部分结论，在现场水压力测试中得到了验证。     

Preparation and performance of dye-sensitized solar cells based on ZnO-modified TiO<Subscript>2</Subscript> electrodes

The ZnO-modified TiO₂ electrode was prepared by adding Zn(CH₃COO)₂·2H₂O to the TiO₂ colloid during the sol-gel production process, and was used in dye-sensitized solar cells (DSCs). The open circuit voltage (V _OC) and fill factor (ff) of the cells were improved significantly. The performances of the ZnO-modified TiO₂ electrode such as dark current, transient photocurrent, impedance, absorption spectra, and flat band potential (V _fb) were investigated. It is found that the interface charge recombination impedance increases and V _fb shifts about 200 mV toward the cathodic potential. The effect mechanism of ZnO modification on the performance of DSCs may be that ZnO occupies the surface states of the TiO₂ film.     

中华主流文化与文化软实力的提升

要使我国从文化大国成为文化强国，从经济大国成为经济强国，必须着力构建中华主流文化，提升文化软实力。其途径一是要正确认识中华主流文化在软实力建设中的核心地位，二是要发挥好文化软实力的积极作用。     

分层介质中原子电四极辐射速率的计算

利用平面分层介质中电磁场Green函数的解析形式,求解位于复杂分层介质结构中的原子电四极自发辐射速率.考虑一特例,结果表明与特殊介质结构中由电磁场模式求解的电四极子衰减速率相同.