人胎儿小脑皮质蒲肯野细胞发育的定量观察

本文应用体视学方法，对３５例不同月龄组的胎儿，观察其小脑皮质蒲肯野细胞在发育过程中的变化．结果发现蒲肯野细胞层在胚胎第６个月时出现，其数密度和核体密度随月龄的增长逐渐减少，细胞的体积则随月龄的增长而逐渐增大．体密度与表面积密度变化不明显．     

提高铝电解槽磁场计算精度的研究

本文讨论了计算铝电解槽磁场的各种数学模型,指出了等效数学模型存在的问题及其在计算中产生误差的原因,提出了提高磁场计算精度应采用实际数学模型,即按母线的实际形状计算各载流母线产生的磁场.     

20CrMo钢化学成份和机械性能关系的统计分析

本文用逐步回归分析方法对生产中的48炉20CrMo钢的机械性能与主要化学成份之间的关系给出了最优的线性数学模型,与生产实测结果比较表明所得的回归模型是满意的。     

新四电极法测定离子溶液和熔体电导率的研究

在Van der Pauw公式基础上,导出了用正方形排列的四电极法测量溶液或熔体电导率的计算公式和测量方法。并设计和制造了DC—1型电导仪,对比实验表明该方法较方便可靠。     

玻璃管空气预热器管内沿程阻力特性的研究

本文指出了目前套用钢管式空气预热器的经验公式计算玻璃管空气预热器管内沿程阻力系数的缺陷,介绍了作者关于硼硅玻璃管空气预热器管内沿程阻力特性的试验研究结果,提出了相应的计算式。     

定常流中立管的多参数分叉

本文讨论立管在拉力、自重及定常流的影响下的非线性分叉问题.奇摄动法用于求解多个独立参数的摄动分叉解.获得了模拟非对称平衡的分叉曲面.文中同时研究了各分叉曲面的稳定性.     

TMS32010数字信号处理器的系统设计与应用

一、TMS32010主要特点 TMS32010是一种新型的数字处理芯片,内部有16×16的硬件乘法器、32比特字长的算逻运算单元ALU、144个数据寄存器以及移位寄存器、辅助寄存器、堆栈和指令计数器等。TMS32010封装在40腿的DIP中,它的寻址能力为4K,对外数据字长为16比特。 TMS32010共有60条指令,可归纳为6类,即累加器操作指令18条;辅助寄存器及数据器指针操作指令7条;程序分支指令13条;T寄存器、P寄存器及乘法指令8条;中断控制及状态寄存器控制指令9条;I/O及存贮器操作指令5条。TMS32010的机器周期为200ns。     

煤层底板采动影响的研究

本文应用相似材料模似方法,研究了煤层底板采动影响。对模型底板岩体进行了综合观测,得到了底板岩体位移及应力的变化规律;並且观测了底板岩体声速变化,用以评价岩体的完整性,指出了底板不同部位裂隙发展变化状况。     

Glioma cell activation by Alzheimer's peptide Abeta1-42, alpha1-antichymotrypsin,and their mixture

We compared the effects ofAlzheimer's peptide (Abeta1-42), a,-antichymotrypsin (ACT) and an ACT/Abeta1-42 mixture on human glioma DK-MG cells. The solution of Abeta (5 microM) formed by 2-h incubation at room temperature induced tumour necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 levels by 55 and 45%, respectively, and increased gelatinase B activity by 67%, while exposure of cells to the ACT/Abeta1-42 mixture (1:10 molar ratio ACT: Abeta1-42) under the same experimental conditions showed no effect on IL-6 levels or gelatinase B activity, but strongly induced TNF-alpha (by 190%), compared to the controls. Stimulation of the cells with Abeta1-42 alone, but not with ACT, increased by about 20% low-density lipoprotein (LDL) uptake and mRNA levels for LDL receptor and HMG-CoA reductase, while the ACT/Abeta1-42 mixture significantly increased LDL uptake (by 50%), up-regulated mRNA levels for LDL receptor and HMG-CoA reductase by 48 and 63%, respectively, and increased lipid accumulation by about 20-fold. These data suggest a possible new role for Abeta in Alzheimer's disease through its interaction with the inflammatory reactant, ACT.     

Spectroscopic investigation on the telomeric DNA base sequence repeat

Telomeres are protein-DNA complexes at the terminals of linear chromosomes, which protect chromosomal integrity and maintain cellular replicative capacity. From single-cell organisms to advanced animals and plants, structures and functions of telomeres are both very conservative. In cells of human and vertebral animals, telomeric DNA base sequences all are (TTAGGG)n. In the present work, we have obtained absorption and fluorescence spectra measured from seven synthesized oligonucleotides to simulate the telomeric DNA system and calculated their relative fluorescence quantum yields on which not only telomeric DNA characteristics are predicted but also possibly the shortened telomeric sequences during cell division are implied. Oligonucleotide 5′-TTAGGGTTAGGG holds a low relative fluorescence quantum yield and remarkable excitation energy innerconversion, which tallies with the telomeric sequence of (TTAGGG)n. This result shows that telomeric DNA has a strong non-radiative or innerconvertible capability.