抑制素及相关肽

换制素一直被认为是一种性腺激素,它对垂体促性腺细胞FSH的分泌具有一定的负馈调节作用。本文综述了近年来抑制素及其相关肽的最新研究。从抑制素的检测方法到结构描述,从抑制素的产生调节到可能的生物作用,本文都做了详尽的叙述。     

甘肃省珙桐的地理分布及群落组成

本文论述和比较了甘肃省的珙桐与全国珙桐的地理分布、生态环境及群落组成特征,对深入研究该植物在我国古植物区系的发生和演化中的意义有参考价值。     

聚乙炔一维共轭多烯半导体

本文介绍了有机共轭体系的结构特点和利用简单Huckel分子轨道(HMO)理论对聚乙炔的电子结构予以处理,以展示其半导体的能带结构和分子中具有长短键交替的特征。并试图从化学角度理解拓扑激发(即孤子)的导电机理。     

疏松含油砂岩薄片的制备

对胜利油田不同类型的储集砂岩的制片方法进行了研究.研究表明.选择低温烤油煮胶和抽真空常压下浸环氧树脂固结样品是制作饱和含油岩样薄片的较理想方案;用502胶形成外套膜后再用低温烤油煮胶,是完成急需样品制片的快速方法;在载物片上用502胶或环氧树脂固结砂粒,制成平面,是解决散砂制片的有效方案.     

Correlation between geometrical parameters of electrical tree and corresponding partial discharge parameters in XLPE

This paper deals with the experimental study on the correlation between the geometrical parameters of electrical tree and corresponding partial discharge (PD) characteristic parameters in the course of electrical tree aging within cross linked polyethylene (XLPE) insulation. The electrical tree aging tests were performed on specimens removed from a section of 220 kV transmission cable. The PD macroscopic characteristic parameters were found to be significantly dependent on the corresponding geometrical parameters of electrical tree channels in the course of aging of XLPE, and different kind of electrical tree has different characteristics, and there is obvious correlation between the type of electrical tree and the pre-applied power-frequency stress. Beside, using regression analysis, the expression of the relation between them were obtained, and from which it can be seen that there is significant nonlinear correlation between geometrical parameters of electrical tree and corresponding PD characteristic parameters in the course of aging of XLPE. Therefore, the aging degree of XLPE can be effectively evaluated by recognizing the changing regularity of the PD rnacroscopic characteristic parameters.     

Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse

Rab3a is the most abundant Rab (ras-associated binding) protein in the brain and has a regulatory role in synaptic vesicle trafficking. Mice with a targeted loss-of-function mutation in Rab3a have defects in Ca(2+)-dependent synaptic transmission: the number of vesicles released in response to an action potential is greater than in wildtype mice, resulting in greater synaptic depression and the abolishment of CA3 mossy-fiber long term potentiation. The effect of these changes on behavior is unknown. In a screen for mouse mutants with abnormal rest-activity and sleep patterns, we identified a semidominant mutation, called earlybird, that shortens the circadian period of locomotor activity. Sequence analysis of Rab3a identified a point mutation in the conserved amino acid (Asp77Gly) within the GTP-binding domain of this protein in earlybird mutants, resulting in significantly reduced levels of Rab3a protein. Phenotypic assessment of earlybird mice and a null allele of Rab3a revealed anomalies in circadian period and sleep homeostasis, providing evidence that Rab3a-mediated synaptic transmission is involved in these behaviors.     

Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development

To rapidly identify genes required for early vertebrate development, we are carrying out a large-scale, insertional mutagenesis screen in zebrafish, using mouse retroviral vectors as the mutagen. We will obtain mutations in 450 to 500 different genes--roughly 20% of the genes that can be mutated to produce a visible embryonic phenotype in this species--and will clone the majority of the mutated alleles. So far, we have isolated more than 500 insertional mutants. Here we describe the first 75 insertional mutants for which the disrupted genes have been identified. In agreement with chemical mutagenesis screens, approximately one-third of the mutants have developmental defects that affect primarily one or a small number of organs, body shape or swimming behavior; the rest of the mutants show more widespread or pleiotropic abnormalities. Many of the genes we identified have not been previously assigned a biological role in vivo. Roughly 20% of the mutants result from lesions in genes for which the biochemical and cellular function of the proteins they encode cannot be deduced with confidence, if at all, from their predicted amino-acid sequences. All of the genes have either orthologs or clearly related genes in human. These results provide an unbiased view of the genetic construction kit for a vertebrate embryo, reveal the diversity of genes required for vertebrate development and suggest that hundreds of genes of unknown biochemical function essential for vertebrate development have yet to be identified.