Glioma cell activation by Alzheimer's peptide Abeta1-42, alpha1-antichymotrypsin,and their mixture

We compared the effects ofAlzheimer's peptide (Abeta1-42), a,-antichymotrypsin (ACT) and an ACT/Abeta1-42 mixture on human glioma DK-MG cells. The solution of Abeta (5 microM) formed by 2-h incubation at room temperature induced tumour necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 levels by 55 and 45%, respectively, and increased gelatinase B activity by 67%, while exposure of cells to the ACT/Abeta1-42 mixture (1:10 molar ratio ACT: Abeta1-42) under the same experimental conditions showed no effect on IL-6 levels or gelatinase B activity, but strongly induced TNF-alpha (by 190%), compared to the controls. Stimulation of the cells with Abeta1-42 alone, but not with ACT, increased by about 20% low-density lipoprotein (LDL) uptake and mRNA levels for LDL receptor and HMG-CoA reductase, while the ACT/Abeta1-42 mixture significantly increased LDL uptake (by 50%), up-regulated mRNA levels for LDL receptor and HMG-CoA reductase by 48 and 63%, respectively, and increased lipid accumulation by about 20-fold. These data suggest a possible new role for Abeta in Alzheimer's disease through its interaction with the inflammatory reactant, ACT.     

连续正整数立方和为素数方幂仅有唯一解

证明了连续正整数的立方和为素数或素数方幂仅有惟一解.     

煤矿工业以太网网络模型研究及应用

在介绍煤矿井下安全监控现状及其信息源特点的基础上,提出了一种与工业现场总线/智能设备相结合的基于交换式工业以太网的煤矿工业控制网络模型,并对其性能进行了分析讨论.结合煤矿的应用实例对其性能参数进行了测试和分析,结果表明该模型可以满足煤矿井下工业控制网络的需要.     

尼卡地平和VM-26逆转C6/VM-26耐药性研究

目的阐明胶质瘤耐药发生的机制,克服耐药性的产生,提高手术后化疗的效果,增加胶质瘤细胞对化疗药物的敏感性,最大限度地抑制胶质瘤细胞增殖,延缓肿瘤复发.方法模拟临床的给药方法,利用VM-26(威猛)在不同条件下的诱导建立了鼠胶质瘤C6细胞株对VM-26的耐药模型,通过钙离子拮抗剂尼卡地平(NCDP)作用,提高了VM-26对耐药的C6细胞株的敏感性.结果利用尼卡地平(5 mg/L)与VM-26协同作用时,使VM-26对C6/VM-26的抑制率从33.45%分别提高到70.25%,与VM-26组之间有显著差异(P<0.01).结论尼卡地平通过与化疗药物竞争地结合肿瘤细胞膜上的P-170糖蛋白,使化疗药物从细胞内泵出减少,细胞内药物积聚增多,增加了化疗药物的细胞毒性,逆转耐药.     

RH-问题在特殊非正则情况下的一种求解方法

在文[1]基础上讨论了当R－问题正则，而H－问题非正则情况下的RH－问题求解方法，得到了一般解的显式及可解条件。     

PGE patterns of ores of Dajing Cu-polymetallic deposit in Linxi County,Inner Mongolia: Indicator to source of metallogenic elements

By comparing PGE patterns of sulfide ores with that of basic-ultrabasic dikes occurring in the Dajing Cu-polymetallic deposit, we discover that there are similar positive slopes between the basic-ultrabasic dikes and the black ores composed mainly of sphalerite and galena, reflecting affinity of their source. The PGE patterns of the yellow ores composed basically of chalcopyrite, arsenopyrite and pyrite are actually different. One is close to the pattern of the mantle lherzolite, and others resemble the pattern of the basic rocks. However, the concentrations of Ru are higher in the yellow ores, reflecting that sulfur attains or approaches saturation in their parent magma. The PGE characteristics of ores and dikes show that the magmas derived from the deep of crust and the metallogenic elements were supplied mainly by growth material of the crust. In addition, the mantle-derived magma also offered some elements.     

北祁连山西段石炭二叠系界线初析兼论对大黄沟群的再研究

在大量野外工作和充分讨论国内外石炭——二叠系界线划分意见的基础上,本文初步分析了北祁连山西段石炭——二叠系界线,讨论了该区大黄沟群、大黄沟组和山西组的关系及时代,指明早二叠世早期地层在北祁连山西段确实存在,没有缺失。     

结构·形态发生与热力学诠解

不同形态能量对物质分布具有不同的作用方向。对孤立系变化过程,体系物质分布与能量形态聚集总量守恒、发散总量守恒。当聚集形态能量对物质分布发生聚集作用时,物质分布将趋向聚集;当发散形态能量对物质分布发生作用时,物质分布将趋于发散。对这两类变化过程,都有量热产生diS>0,这表明量热滴变dS不能作为体系物质分布特征变化（方向）的判断依据。     

电场诱导细胞融合产生杂交瘤

摸索和探讨了HPES-1型高级基因转移仪在BALB/C小鼠脾细胞与小鼠骨髓瘤细胞SP2/0电融合中的应用,获得了一组选择参数,采用短脉冲输出方式,脉冲幅度6kV,脉冲宽度50μs,脉冲数2~9,循环数50×2及脉冲休止时间2s的电融合参数,纳合高细胞密度(10~5cell/200μl)增加细胞间聚集的方法,可较容易地获得杂交瘤,并应用该技术成功地制备了分泌人血清白蛋白单克隆抗体的杂交瘤。     

磁性超微粒的线度效应和分形特性

讨论了磁性超微粒磁结构的线度效应(单畴结构,超顺磁驰豫)、磁特性的线度效应(饱和磁化强度、矫顽力、磁化率及磁转变温度)、磁聚集的分形特性以及线度效应对粒子分形聚集的影响,并介绍了目前有关的实验研究和理论工作进展.