Preparation of rare-earth-modified medical stone powders and their application as conductive fillers

Traditional metal conductive fillers are expensive and prone to oxidation. Thus, the development of new conductive powders as fillers is urgently needed. A novel gaseous penetration technology was adopted to prepare La-doped medical stone powders(La-MSPs), which are inexpensive mesoporous materials, as a new kind of conductive filler material. The prepared La-MSPs attained a resistivity of 450 ?·m and were used as a filler to prepare conductive coatings with epoxy resin as the resin matrix. The influence of the La-MSPs dosage on the resistance and hardness of the coatings was also determined. The resistance and the hardness both decreased with increasing filler dosage. Finally, the optimum recipe of the conductive coatings with the most suitable fillers dosage(55 wt%) was obtained. The hardness and resistance of the coatings with 55 wt% La-MSPs were HV 4 and 5.5 × 10~7 ?, respectively.     

阳离子钴催化剂的合成及其对1,3-丁二烯聚合行为的影响

合成了一系列带有含氮中性配体(1,10-邻菲咯啉(Phen)、2,2-联吡啶、咪唑、吡啶)以及阴离子配体(三氟甲烷磺酸、甲烷磺酸)的阳离子钴化合物,同时Co(Phen)2Cl2化合物也被合成出来作为参比物。通过元素分析以及红外光谱特征分析确定了所有化合物的结构,其中部分化合物的结构通过单晶X-射线晶体学分析得以进一步证实。在以倍半乙基铝为助催化剂的情况下,这些阳离子钴化合物被用于丁二烯聚合时表现出很好的催化活性。最后通过对丁二烯聚合行为的研究,分析了不同反应条件、不同配体的空间效应以及电子效应对其活性的影响。     

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Among these tyrosine residues, Y842 is located in the so-called activation loop. The position of this tyrosine residue is well conserved in all receptor tyrosine kinases. It has been reported that phosphorylation of the activation loop tyrosine is critical for catalytic activity for some but not all receptor tyrosine kinases. The role of Y842 residue in FLT3 signaling has not yet been studied. In this report, we show that Y842 is not important for FLT3 activation or ubiquitination but plays a critical role in regulating signaling downstream of the receptor as well as controlling receptor stability. We found that mutation of Y842 in the FLT3-ITD oncogenic mutant background reduced cell viability and increased apoptosis. Furthermore, the introduction of the Y842 mutation in the FLT3-ITD background led to a dramatic reduction in in vitro colony forming capacity. Additionally, mice injected with cells expressing FLT3-ITD/Y842F displayed a significant delay in tumor formation, compared to FLT3-ITD expressing cells. Microarray analysis comparing gene expression regulated by FLT3-ITD versus FLT3-ITD/Y842F demonstrated that mutation of Y842 causes suppression of anti-apoptotic genes. Furthermore, we showed that cells expressing FLT3-ITD/Y842F display impaired activity of the RAS/ERK pathway due to reduced interaction between FLT3 and SHP2 leading to reduced SHP2 activation. Thus, we suggest that Y842 is critical for FLT3-mediated RAS/ERK signaling and cellular transformation.     

基于可接受性标准的复杂产品仿真系统在线评估框架

针对当前复杂仿真系统评估的滞后性问题,提出了基于可接受性标准(Acceptability Criteria,AC)的仿真在线评估方法。通过定性和定量AC到指标的映射模型来建立评估指标体系;引入指标集和评估函数,提出了仿真评估流程有限自动机七元组模型,给出仿真流程到评估自动机的映射关系和基于数据驱动的状态转移机制,实现评估过程自动化执行过程;基于上述成果设计了在线评估工具,通过案例验证了在线评估方法的有效性,表明该方法能够有效解决仿真系统评估滞后性问题。     

The predictability of stock market volatility in emerging economies: Relative roles of local,regional, and global business cycles

This paper explores the role of business cycle proxies, measured by the output gap at the global, regional, and local levels, as potential predictors of stock market volatility in the emerging BRICS nations. We observe that the emerging BRICS nations display a rather heterogeneous pattern when it comes to the relative role of idiosyncratic factors as a predictor of stock market volatility. While domestic output gap is found to capture significant predictive information for India and China particularly, the business cycles associated with emerging economies and the world in general are strongly important for the BRIC countries and weakly for South Africa, especially in the postglobal financial crisis era. The findings suggest that despite the increase in the financial integration of world capital markets, emerging economies can still bear significant exposures to idiosyncratic risk factors, an issue of high importance for the profitability of global diversification strategies.     

On implementing the symbolic preprocessing function over Boolean polynomial rings in Gröbner basis algorithms using linear algebra

Some techniques using linear algebra was introduced by Faugère in F4 to speed up the reduction process during Gr?bner basis computations.These techniques can also be used in fast implementations of F5 and some other signature-based Gr?bner basis algorithms.When these techniques are applied,a very important step is constructing matrices from critical pairs and existing polynomials by the Symbolic Preprocessing function(given in F4).Since multiplications of monomials and polynomials are involved in the Symbolic Preprocessing function,this step can be very costly when the number of involved polynomials/monomials is huge.In this paper,multiplications of monomials and polynomials for a Boolean polynomial ring are investigated and a specific method of implementing the Symbolic Preprocessing function over Boolean polynomial rings is reported.Many examples have been tested by using this method,and the experimental data shows that the new method is very efficient.     

Advance selling in the presence of product diffusion effect

Product diffusion refers to the phenomenon that the later demand is dependent on the early sales. To investigate how a firm’s advance selling strategy is affected by the effect of product diffusion, we consider a monopolist seller who sells a fashionable product in a market that comprises of myopic and strategic consumers over two periods (i.e., the advance selling season and the regular selling season). For a linear product diffusion effect we find that, when the effect of product diffusion is positive, the seller may set an extremely high advance selling price to induce the strategic consumers to purchase in the regular selling season, which is counter-intuitive. Moreover, the optimal procurement quantity for the seller may increase in the negative effect of product diffusion and decrease in the amount of strategic consumers. When we extend our model to consider a concave quadratic product diffusion effect, however, the optimal procurement quantity is concave in the amount of strategic consumers. Numerical studies are further presented to discuss the managerial insights.     

朝鲜崖柏生境及高生长规律分析

采用标准地调查法测定朝鲜崖柏的土壤特征、林下植被和高生长规律.结果表明:朝鲜崖柏生长于土层较薄且呈弱酸性的山地暗棕壤,不同标准地林下植被差异明显;不同标准地朝鲜崖柏树高的年生长量均呈逐年下降趋势.     

基于局部紧耦合结构的模块性优化社区检测方法

利用局部紧耦合结构提升社区检测的模块性优化质量.首先,定义了4类边缘紧耦合结构,并提出了一种具有线性复杂度的边缘紧耦合结构挖掘算法.其次,分别选择k-clique,k-clan,k-plex结构作为核心紧耦合结构,并以长结构优先和短结构优先2种策略将边缘与核心紧耦合结构合并.然后,将合并后的局部紧耦合结构融入模块性优化过程,提出了一种NFN算法.该算法将每个局部紧耦合结构初始化为独立社区,不断凝聚模块性增量最大的2个社区,直至找到预定义数量的社区.6个真实数据集上针对外部指标和内部指标的实验结果均表明,相比于传统的FN算法,NFN算法能发现更高质量的社区.在参数设置方面,长结构优先策略优于短结构优先策略,且采用k-clique结构作为核心紧耦合结构优于采用其他结构.因此,长结构优先策略结合k-clique成为NFN算法的最佳参数组合.