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71.
S Tachibana SA Sullivan S Kawai S Nakamura HR Kim N Goto N Arisue NM Palacpac H Honma M Yagi T Tougan Y Katakai O Kaneko T Mita K Kita Y Yasutomi PL Sutton R Shakhbatyan T Horii T Yasunaga JW Barnwell AA Escalante JM Carlton K Tanabe 《Nature genetics》2012,44(9):1051-1055
P. cynomolgi, a malaria-causing parasite of Asian Old World monkeys, is the sister taxon of P. vivax, the most prevalent malaria-causing species in humans outside of Africa. Because P. cynomolgi shares many phenotypic, biological and genetic characteristics with P. vivax, we generated draft genome sequences for three P. cynomolgi strains and performed genomic analysis comparing them with the P. vivax genome, as well as with the genome of a third previously sequenced simian parasite, Plasmodium knowlesi. Here, we show that genomes of the monkey malaria clade can be characterized by copy-number variants (CNVs) in multigene families involved in evasion of the human immune system and invasion of host erythrocytes. We identify genome-wide SNPs, microsatellites and CNVs in the P. cynomolgi genome, providing a map of genetic variation that can be used to map parasite traits and study parasite populations. The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax. 相似文献
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74.
Sullivan S. G. Ghosh N. K. Deutsch S. I. Day D. G. Cox R. P. 《Cellular and molecular life sciences : CMLS》1983,39(7):788-790
Cellular and Molecular Life Sciences - Agglutinability by concanavalin A was measured with HeLa65 cells grown with prednisolone or sodium butyrate, 2 compounds that increase the activity of the... 相似文献
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76.
Stephen R. Goldberg Charles R. Bursey Keith B. Malmos Brian K. Sullivan Hay Cheam 《西北部美国博物学家》2011,56(4)
The gastrointestinal tracts, lungs and urinary bladders from 77 Bufo microscaphus , 61 Bufo woodhousii , and 8 of their hybrids were examined for helminthes. One species of trematode ( Glypthelmins quieta ), 1 species of cestode ( Distoichometra bufonis ), and 5 species of nematodes ( Aplectana incerta, A. itzocanensis, Rhabdias americanus, Physaloptera sp., and Physocephalus sp.) were found. The greatest prevalence (41%) and mean intensity (231.7) were recorded for Aplectana incerta in Bufo woodhousii . It appears hybrids harbor fewer parasites than either parent species. 相似文献
77.
A new feathered maniraptoran dinosaur fossil that fills a morphological gap in avian origin 总被引:3,自引:0,他引:3
Recent fossil discoveries have substantially reduced the morphological gap between non-avian and avian dinosaurs, yet avians
including Archaeopteryx differ from non-avian theropods in their limb proportions. In particular, avians have proportionally longer and more robust
forelimbs that are capable of supporting a large aerodynamic surface. Here we report on a new maniraptoran dinosaur, Anchiornis huxleyi gen. et sp. nov., based on a specimen collected from lacustrine deposits of uncertain age in western Liaoning, China. With
an estimated mass of 110 grams, Anchiornis is the smallest known non-avian theropod dinosaur. It exhibits some wrist features indicative of high mobility, presaging
the wing-folding mechanisms seen in more derived birds and suggesting rapid evolution of the carpus. Otherwise, Anchiornis is intermediate in general morphology between non-avian and avian dinosaurs, particularly with regard to relative forelimb
length and thickness, and represents a transitional step toward the avian condition. In contrast with some recent comprehensive
phylogenetic analyses, our phylogenetic analysis incorporates subtle morphological variations and recovers a conventional
result supporting the monophyly of Avialae.
Supported by Hundred Talents Project of the Chinese Academy of Sciences, National Natural Science Foundation of China (Grant
Nos. 40125006, 40472018), and National Basic Research Program of China (Grant No. 2006CB806400) 相似文献
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T. J. Sullivan 《Cellular and molecular life sciences : CMLS》1964,20(3):151-152
Zusammenfassung Reserpin verhindert sofort die elektrische Reizbarkeit des isolierten Meerschweinchenuterus. Eine Depression wurde von einigen Substanzen nur partiell bewirkt, wobei sich auffallende Wirkungsunterschiede zeigten. 相似文献
80.
Li W Moore MJ Vasilieva N Sui J Wong SK Berne MA Somasundaran M Sullivan JL Luzuriaga K Greenough TC Choe H Farzan M 《Nature》2003,426(6965):450-454
Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their target cells. Here we identify a metallopeptidase, angiotensin-converting enzyme 2 (ACE2), isolated from SARS coronavirus (SARS-CoV)-permissive Vero E6 cells, that efficiently binds the S1 domain of the SARS-CoV S protein. We found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells. 293T cells transfected with ACE2, but not those transfected with human immunodeficiency virus-1 receptors, formed multinucleated syncytia with cells expressing S protein. Furthermore, SARS-CoV replicated efficiently on ACE2-transfected but not mock-transfected 293T cells. Finally, anti-ACE2 but not anti-ACE1 antibody blocked viral replication on Vero E6 cells. Together our data indicate that ACE2 is a functional receptor for SARS-CoV. 相似文献