排序方式: 共有33条查询结果,搜索用时 18 毫秒
1.
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer 总被引:1,自引:0,他引:1
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Zusammenfassung Es wird gezeigt, dass Injektion von Rizinus-Extrakt die Plaque-Bildung im Jerne-Test fördert, was dafür spricht, dass die zytostatische Wirkung des Rizinus mit der Adjuvansfähigkeit gekoppelt ist.
We are greatly indebted to Drs. M.Funatsu and G.Funatsu for their supply for ricin and to Miss Y.Nagakawa for her excellent technical assistance. 相似文献
We are greatly indebted to Drs. M.Funatsu and G.Funatsu for their supply for ricin and to Miss Y.Nagakawa for her excellent technical assistance. 相似文献
3.
RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing 总被引:10,自引:0,他引:10
Noma K Sugiyama T Cam H Verdel A Zofall M Jia S Moazed D Grewal SI 《Nature genetics》2004,36(11):1174-1180
4.
Inductive cell-cell interactions are essential for controlling cell fate determination in both plants and animals; however, the chemical basis of inductive signals in plants remains little understood. A proteoglycan-like factor named xylogen mediates local and inductive cell-cell interactions required for xylem differentiation in Zinnia cells cultured in vitro. Here we describe the purification of xylogen and cloning of its complementary DNA, and present evidence for its role in planta. The polypeptide backbone of xylogen is a hybrid-type molecule with properties of both arabinogalactan proteins and nonspecific lipid-transfer proteins. Xylogen predominantly accumulates in the meristem, procambium and xylem. In the xylem, xylogen has a polar localization in the cell walls of differentiating tracheary elements. Double knockouts of Arabidopsis lacking both genes that encode xylogen proteins show defects in vascular development: discontinuous veins, improperly interconnected vessel elements and simplified venation. Our results suggest that the polar secretion of xylogen draws neighbouring cells into the pathway of vascular differentiation to direct continuous vascular development, thereby identifying a molecule that mediates an inductive cell-cell interaction involved in plant tissue differentiation. 相似文献
5.
An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene 总被引:40,自引:0,他引:40
Hirotsune S Yoshida N Chen A Garrett L Sugiyama F Takahashi S Yagami K Wynshaw-Boris A Yoshiki A 《Nature》2003,423(6935):91-96
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K Sugiyama 《Nature》1977,270(5638):614-615
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S. Sugiyama M. Kitazawa T. Ozawa K. Suzuki Y. Izawa 《Cellular and molecular life sciences : CMLS》1980,36(8):1002-1003
Summary Coenzyme Q10 is effective as an anti-oxidant like -tocopherol, especially in the heart. 相似文献
9.
Hoshino K Sugiyama T Matsumoto M Tanaka T Saito M Hemmi H Ohara O Akira S Kaisho T 《Nature》2006,440(7086):949-953
The Toll-like receptor (TLR) family has important roles in microbial recognition and dendritic cell activation. TLRs 7 and 9 can recognize nucleic acids and trigger signalling cascades that activate plasmacytoid dendritic cells to produce interferon-alpha (IFN-alpha) (refs 7, 8). TLR7/9-mediated dendritic cell activation is critical for antiviral immunity but also contributes to the pathogenesis of systemic lupus erythematosus, a disease in which serum IFN-alpha levels are elevated owing to plasmacytoid dendritic cell activation. TLR7/9-induced IFN-alpha induction depends on a molecular complex that contains a TLR adaptor, MyD88, and IFN regulatory factor 7 (IRF-7) (refs 10-14), but the underlying molecular mechanisms are as yet unknown. Here we show that IkappaB kinase-alpha (IKK-alpha) is critically involved in TLR7/9-induced IFN-alpha production. TLR7/9-induced IFN-alpha production was severely impaired in IKK-alpha-deficient plasmacytoid dendritic cells, whereas inflammatory cytokine induction was decreased but still occurred. Kinase-deficient IKK-alpha inhibited the ability of MyD88 to activate the Ifna promoter in synergy with IRF-7. Furthermore, IKK-alpha associated with and phosphorylated IRF-7. Our results identify a role for IKK-alpha in TLR7/9 signalling, and highlight IKK-alpha as a potential target for manipulating TLR-induced IFN-alpha production. 相似文献
10.
Erika Gucciardo Nami Sugiyama Kaisa Lehti 《Cellular and molecular life sciences : CMLS》2014,71(19):3685-3710
The erythropoietin-producing hepatocellular (Eph) receptors comprise the largest family of receptor tyrosine kinases (RTKs). Initially regarded as axon-guidance and tissue-patterning molecules, Eph receptors have now been attributed with various functions during development, tissue homeostasis, and disease pathogenesis. Their ligands, ephrins, are synthesized as membrane-associated molecules. At least two properties make this signaling system unique: (1) the signal can be simultaneously transduced in the receptor- and the ligand-expressing cell, (2) the signaling outcome through the same molecules can be opposite depending on cellular context. Moreover, shedding of Eph and ephrin ectodomains as well as ligand-dependent and -independent receptor crosstalk with other RTKs, proteases, and adhesion molecules broadens the repertoire of Eph/ephrin functions. These integrated pathways provide plasticity to cell–microenvironment communication in varying tissue contexts. The complex molecular networks and dynamic cellular outcomes connected to the Eph/ephrin signaling in tumor–host communication and stem cell niche are the main focus of this review. 相似文献