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82.
Human gut microbiome viewed across age and geography 总被引:2,自引:0,他引:2
Yatsunenko T Rey FE Manary MJ Trehan I Dominguez-Bello MG Contreras M Magris M Hidalgo G Baldassano RN Anokhin AP Heath AC Warner B Reeder J Kuczynski J Caporaso JG Lozupone CA Lauber C Clemente JC Knights D Knight R Gordon JI 《Nature》2012,486(7402):222-227
Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono- and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization. 相似文献
83.
H Pälike MW Lyle H Nishi I Raffi A Ridgwell K Gamage A Klaus G Acton L Anderson J Backman J Baldauf C Beltran SM Bohaty P Bown W Busch JE Channell CO Chun M Delaney P Dewangan T Dunkley Jones KM Edgar H Evans P Fitch GL Foster N Gussone H Hasegawa EC Hathorne H Hayashi JO Herrle A Holbourn S Hovan K Hyeong K Iijima T Ito S Kamikuri K Kimoto J Kuroda L Leon-Rodriguez A Malinverno TC Moore BH Murphy DP Murphy H Nakamura K Ogane C Ohneiser C Richter R Robinson EJ Rohling O Romero K Sawada H Scher 《Nature》2012,488(7413):609-614
Atmospheric carbon dioxide concentrations and climate are regulated on geological timescales by the balance between carbon input from volcanic and metamorphic outgassing and its removal by weathering feedbacks; these feedbacks involve the erosion of silicate rocks and organic-carbon-bearing rocks. The integrated effect of these processes is reflected in the calcium carbonate compensation depth, which is the oceanic depth at which calcium carbonate is dissolved. Here we present a carbonate accumulation record that covers the past 53 million years from a depth transect in the equatorial Pacific Ocean. The carbonate compensation depth tracks long-term ocean cooling, deepening from 3.0-3.5?kilometres during the early Cenozoic (approximately 55?million years ago) to 4.6 kilometres at present, consistent with an overall Cenozoic increase in weathering. We find large superimposed fluctuations in carbonate compensation depth during the middle and late Eocene. Using Earth system models, we identify changes in weathering and the mode of organic-carbon delivery as two key processes to explain these large-scale Eocene fluctuations of the carbonate compensation depth. 相似文献
84.
Fünfschilling U Supplie LM Mahad D Boretius S Saab AS Edgar J Brinkmann BG Kassmann CM Tzvetanova ID Möbius W Diaz F Meijer D Suter U Hamprecht B Sereda MW Moraes CT Frahm J Goebbels S Nave KA 《Nature》2012,485(7399):517-521
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity. However, the underlying support mechanisms are not understood. Here we identify a metabolic component of axon-glia interactions by generating conditional Cox10 (protoheme IX farnesyltransferase) mutant mice, in which oligodendrocytes and Schwann cells fail to assemble stable mitochondrial cytochrome c oxidase (COX, also known as mitochondrial complex IV). In the peripheral nervous system, Cox10 conditional mutants exhibit severe neuropathy with dysmyelination, abnormal Remak bundles, muscle atrophy and paralysis. Notably, perturbing mitochondrial respiration did not cause glial cell death. In the adult central nervous system, we found no signs of demyelination, axonal degeneration or secondary inflammation. Unlike cultured oligodendrocytes, which are sensitive to COX inhibitors, post-myelination oligodendrocytes survive well in the absence of COX activity. More importantly, by in vivo magnetic resonance spectroscopy, brain lactate concentrations in mutants were increased compared with controls, but were detectable only in mice exposed to volatile anaesthetics. This indicates that aerobic glycolysis products derived from oligodendrocytes are rapidly metabolized within white matter tracts. Because myelinated axons can use lactate when energy-deprived, our findings suggest a model in which axon-glia metabolic coupling serves a physiological function. 相似文献
85.
Tirichine L Imaizumi-Anraku H Yoshida S Murakami Y Madsen LH Miwa H Nakagawa T Sandal N Albrektsen AS Kawaguchi M Downie A Sato S Tabata S Kouchi H Parniske M Kawasaki S Stougaard J 《Nature》2006,441(7097):1153-1156
Induced development of a new plant organ in response to rhizobia is the most prominent manifestation of legume root-nodule symbiosis with nitrogen-fixing bacteria. Here we show that the complex root-nodule organogenic programme can be genetically deregulated to trigger de novo nodule formation in the absence of rhizobia or exogenous rhizobial signals. In an ethylmethane sulphonate-induced snf1 (spontaneous nodule formation) mutant of Lotus japonicus, a single amino-acid replacement in a Ca2+/calmodulin-dependent protein kinase (CCaMK) is sufficient to turn fully differentiated root cortical cells into meristematic founder cells of root nodule primordia. These spontaneous nodules are genuine nodules with an ontogeny similar to that of rhizobial-induced root nodules, corroborating previous physiological studies. Using two receptor-deficient genetic backgrounds we provide evidence for a developmentally integrated spontaneous nodulation process that is independent of lipochitin-oligosaccharide signal perception and oscillations in Ca2+ second messenger levels. Our results reveal a key regulatory position of CCaMK upstream of all components required for cell-cycle activation, and a phenotypically divergent series of mutant alleles demonstrates positive and negative regulation of the process. 相似文献
86.
Sabine D. Jordan A. Christine Könner Jens C. Brüning 《Cellular and molecular life sciences : CMLS》2010,67(19):3255-3273
The central nervous system (CNS) is capable of gathering information on the body’s nutritional state and it implements appropriate
behavioral and metabolic responses to changes in fuel availability. This feedback signaling of peripheral tissues ensures
the maintenance of energy homeostasis. The hypothalamus is a primary site of convergence and integration for these nutrient-related
feedback signals, which include central and peripheral neuronal inputs as well as hormonal signals. Increasing evidence indicates
that glucose and lipids are detected by specialized fuel-sensing neurons that are integrated in these hypothalamic neuronal
circuits. The purpose of this review is to outline the current understanding of fuel-sensing mechanisms in the hypothalamus,
to integrate the recent findings in this field, and to address the potential role of dysregulation in these pathways in the
development of obesity and type 2 diabetes mellitus. 相似文献
87.
Sluijs A Schouten S Pagani M Woltering M Brinkhuis H Sinninghe Damsté JS Dickens GR Huber M Reichart GJ Stein R Matthiessen J Lourens LJ Pedentchouk N Backman J Moran K;Expedition Scientists 《Nature》2006,441(7093):610-613
The Palaeocene/Eocene thermal maximum, approximately 55 million years ago, was a brief period of widespread, extreme climatic warming, that was associated with massive atmospheric greenhouse gas input. Although aspects of the resulting environmental changes are well documented at low latitudes, no data were available to quantify simultaneous changes in the Arctic region. Here we identify the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence obtained during the Arctic Coring Expedition. We show that sea surface temperatures near the North Pole increased from 18 degrees C to over 23 degrees C during this event. Such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming. At the same time, sea level rose while anoxic and euxinic conditions developed in the ocean's bottom waters and photic zone, respectively. Increasing temperature and sea level match expectations based on palaeoclimate model simulations, but the absolute polar temperatures that we derive before, during and after the event are more than 10 degrees C warmer than those model-predicted. This suggests that higher-than-modern greenhouse gas concentrations must have operated in conjunction with other feedback mechanisms--perhaps polar stratospheric clouds or hurricane-induced ocean mixing--to amplify early Palaeogene polar temperatures. 相似文献
88.
Episodic fresh surface waters in the Eocene Arctic Ocean 总被引:1,自引:0,他引:1
Brinkhuis H Schouten S Collinson ME Sluijs A Sinninghe Damsté JS Dickens GR Huber M Cronin TM Onodera J Takahashi K Bujak JP Stein R van der Burgh J Eldrett JS Harding IC Lotter AF Sangiorgi F van Konijnenburg-van Cittert H de Leeuw JW Matthiessen J Backman J Moran K;Expedition Scientists 《Nature》2006,441(7093):606-609
It has been suggested, on the basis of modern hydrology and fully coupled palaeoclimate simulations, that the warm greenhouse conditions that characterized the early Palaeogene period (55-45 Myr ago) probably induced an intensified hydrological cycle with precipitation exceeding evaporation at high latitudes. Little field evidence, however, has been available to constrain oceanic conditions in the Arctic during this period. Here we analyse Palaeogene sediments obtained during the Arctic Coring Expedition, showing that large quantities of the free-floating fern Azolla grew and reproduced in the Arctic Ocean by the onset of the middle Eocene epoch (approximately 50 Myr ago). The Azolla and accompanying abundant freshwater organic and siliceous microfossils indicate an episodic freshening of Arctic surface waters during an approximately 800,000-year interval. The abundant remains of Azolla that characterize basal middle Eocene marine deposits of all Nordic seas probably represent transported assemblages resulting from freshwater spills from the Arctic Ocean that reached as far south as the North Sea. The termination of the Azolla phase in the Arctic coincides with a local sea surface temperature rise from approximately 10 degrees C to 13 degrees C, pointing to simultaneous increases in salt and heat supply owing to the influx of waters from adjacent oceans. We suggest that onset and termination of the Azolla phase depended on the degree of oceanic exchange between Arctic Ocean and adjacent seas. 相似文献
89.
Moran K Backman J Brinkhuis H Clemens SC Cronin T Dickens GR Eynaud F Gattacceca J Jakobsson M Jordan RW Kaminski M King J Koc N Krylov A Martinez N Matthiessen J McInroy D Moore TC Onodera J O'Regan M Pälike H Rea B Rio D Sakamoto T Smith DC Stein R St John K Suto I Suzuki N Takahashi K Watanabe M Yamamoto M Farrell J Frank M Kubik P Jokat W Kristoffersen Y 《Nature》2006,441(7093):601-605
The history of the Arctic Ocean during the Cenozoic era (0-65 million years ago) is largely unknown from direct evidence. Here we present a Cenozoic palaeoceanographic record constructed from >400 m of sediment core from a recent drilling expedition to the Lomonosov ridge in the Arctic Ocean. Our record shows a palaeoenvironmental transition from a warm 'greenhouse' world, during the late Palaeocene and early Eocene epochs, to a colder 'icehouse' world influenced by sea ice and icebergs from the middle Eocene epoch to the present. For the most recent approximately 14 Myr, we find sedimentation rates of 1-2 cm per thousand years, in stark contrast to the substantially lower rates proposed in earlier studies; this record of the Neogene reveals cooling of the Arctic that was synchronous with the expansion of Greenland ice (approximately 3.2 Myr ago) and East Antarctic ice (approximately 14 Myr ago). We find evidence for the first occurrence of ice-rafted debris in the middle Eocene epoch (approximately 45 Myr ago), some 35 Myr earlier than previously thought; fresh surface waters were present at approximately 49 Myr ago, before the onset of ice-rafted debris. Also, the temperatures of surface waters during the Palaeocene/Eocene thermal maximum (approximately 55 Myr ago) appear to have been substantially warmer than previously estimated. The revised timing of the earliest Arctic cooling events coincides with those from Antarctica, supporting arguments for bipolar symmetry in climate change. 相似文献
90.
For animals that forage or travel in groups, making movement decisions often depends on social interactions among group members. However, in many cases, few individuals have pertinent information, such as knowledge about the location of a food source, or of a migration route. Using a simple model we show how information can be transferred within groups both without signalling and when group members do not know which individuals, if any, have information. We reveal that the larger the group the smaller the proportion of informed individuals needed to guide the group, and that only a very small proportion of informed individuals is required to achieve great accuracy. We also demonstrate how groups can make consensus decisions, even though informed individuals do not know whether they are in a majority or minority, how the quality of their information compares with that of others, or even whether there are any other informed individuals. Our model provides new insights into the mechanisms of effective leadership and decision-making in biological systems. 相似文献