蚕丝蛋白仿生多肽RAGA16的纳米结构与性能研究

利用天然蛋白质氨基酸序列设计生物仿生材料是近年来兴起的一个热门研究领域.本文中将蚕丝蛋白特征氨基酸序列(Gly-Ala-Gly-Ala-Gly-Ser)部分引入离子互补型多肽RA-DA16-Ⅰ中,设计了新型多肽RAGA16.采用原子力显微镜(AFM)、旋转流变仪(Rheometer)、傅立叶变换红外光谱仪(FTIR)、倒置荧光显微镜等技术对多肽RAGA16的自组装结构、肽链的二级结构、流变学性能以及细胞相容性等进行研究.结果表明,蚕丝蛋白多肽序列引入后,多肽RAGA16具有自组装特性,能够自组装形成致密的纳米级三维网络结构,所形成的水凝胶力学性能明显提高,通过分析得知这可能是由于多肽二级结构中Silk Ⅰ结构成分比例增加所致.荧光染色显示,绝大多数接种于多肽水凝胶中的小鼠前成骨细胞MC3T3-E1能存活,且在不同的三维平面上生长增殖.综上,利用蚕丝蛋白特征序列对RADA16-Ⅰ进行仿生改性后,对拓展多肽材料在生物医学领域的应用具有重要意义.     

Petrogenesis of Aoyougou high-silica adakite in the North Qilian orogen, NW China: Evidence for decompression melting of oceanic slab

A trondhjemitic body occurs in the Aoyougou area,the western part of the North Qilian orogen.It is geochemically characterized by high SiO 2,Na 2 O (high Na/K),elevated Sr/Y and (La/Yb) N,positive Sr anomaly,relatively enriched large ion lithophile elements (LILEs) and light rare earth elements (LREEs),and depleted Nb,Ta,Ti,resembling the high-silica adakite.Zircon U-Pb SHRIMP dating yields a weighted mean age of 438±3 Ma.This age is significantly younger than eclogitization ages of 460-490 Ma in the North Qilian orogen,suggesting that formation of the adakite postdates the subduction of oceanic crust in association with closure of the ancient Qilian Ocean.Whole-rock Sr and Nd isotopic analyses give initial ratios of I Sr =0.7044 0.7047 and Nd (t)=3.0 4.1,indicating that they are derived from partial melting of the juvenile oceanic crust.In view of the tectonic evolution of the North Qilian orogen,the high-silica adakite was probably derived from decompression melting of the exhumed eclogite at the depth of ～60 km.     

Leptomeningeal metastasis from central nervous system tumors: A study of classification and stage in the spinal canal of 58 patients

Leptomeningeal metastasis (LM) is caused by the spread of malignant tumor cells into the subarachnoid space.However,classification and staging of LM in the spinal canal is rare in the literature.The authors reviewed the records of 58 Chinese patients with LM for clinical features,neuroimaging,and treatments.Gadolinium-enhanced magnetic resonance imaging (MRI) of brain and spinal cord were performed in all patients.Removal of intracranial tumors was performed in all patients and diagnoses were confirmed by histology.The study group consisted of 58 patients,with 29 cases presenting with intraspinal symptoms.Of the 58,8 patients underwent intraspinal tumor removal,8 received radiotherapy alone,9 received chemotherapy alone,and 34 patients received combined radiochemotherapy.We classified LM into 3 types:type L or leptomeninges LM,is subdivided into 2 subtypes (subtype LI and LII (a,b)),type N or nerve root LM is subdivided into 2 subtypes (subtype NI and NII (a,b)),and type M or mixed-type LM.We also divided LM into stages of I-IV according to the symptoms and the volume of the tumor based on spinal axial MRI.Type LI LM often occurs in patients with intracranial and intraspinal tumors found simultaneously.Patients who receive surgery for intracranial tumors may present with type N LM.Surgery is suitable for patients with NI LM and LIIb LM in stages III-IV,presenting with severe spinal symptoms.The prognosis is better for type N LM than type L LM.     

Degradation of the antibiotic sulfamonomethoxine sodium in aqueous solution by photo-Fenton oxidation

In this study, photo-Fenton oxidation was applied to degradation of sulfamonomethoxine sodium (SMMS) in aqueous solution. The operation parameters of pH, temperature, and concentrations of H2O2, Fe2+ and SMMS were investigated. The optimum conditions for the photo-Fenton process were determined as follows: [SMMS]=4.53 mg/L, pH 4.0, [H2O2]=0.49 mmol/L, [Fe2+]= 19.51 μmol/L and T=25°C. Under these conditions 98.5% of the SMMS degraded. The kinetics were also studied, and degradation of SMMS by the photo-Fenton process could be described by first-order kinetics. The apparent activation energy was calculated as 23.95 kJ/mol. Mineralization of the process was investigated by measuring the chemical oxygen demand (COD), and the COD decreased by 99% after 120 min. This process could be used as a pretreatment method for wastewater containing sulfamonomethoxine sodium.     

MIMO干扰信道下基于功率分配的干扰抑制算法

为了抑制MIMO干扰信道下的多小区干扰,采用子空间干扰抑制算法和功率分配相结合的干扰抑制方案,该方案充分利用系统总功率,将多小区干扰尽可能地重叠,以提高系统的性能.理论分析及仿真结果表明,与传统干扰抑制方案相比,该方案仅牺牲极微小的系统容量,却明显地降低了系统的干扰功率.     

藏族小说审美价值探析

文章从审美倾向、表现手法等方面探讨了藏族小说旨在穿越历史探寻规律,挖掘藏民族个体与群体的精神世界及其与宗教文化的关系,着力表现藏族百姓的人性美、藏族英雄的崇高美和青藏高原的神奇美等方面的审美价值以及审美趋向。     

平面漫反射板对真空太阳集热管能量采集的影响

提出了平面漫反射板对真空太阳集热管能量采集贡献的计算模型.计算结果表明,在垂直入射光线下,平面漫反射板对真空太阳集热管能量采集的贡献较大,且依其结构因子的不同而不同.     

Co-W磁性薄膜应变对其有效磁晶各向异性能的影响

利用磁控溅射在250℃的MgO(220)单晶基片上先后沉积Cr(100 nm)下底层和不同厚度(9~80 nm)的Co-11%W(原子分数)磁性层,二者取向附生生长关系为Cr(112)[111]∥Co-W(1010)[1210]和Cr(112)[110]∥Co-W(1010)[0001].随着膜厚的增加,Co-W在薄膜面内的压应变(ε0)从0.781 3%减小到0.544 5%,相应地其有效磁晶各向异性能一级常数Ke1ff由3.82×106减小到2.58×106erg/cc.该结果表明通过设计磁性层和下底层之...     

大直径泥水盾构浅覆土穿越机场的风险演化分析

以上海市仙霞西路隧道地下穿越虹桥机场绕滑道工程为背景,对其规划设计、施工和运营3个阶段的风险因素及其相互关联性和演化关系进行了分析,并提出了风险演化的概念,在一定程度上实现了机场飞行区穿越工程的全过程风险识别.结果表明,盾构隧道3个阶段之间的风险演化为其风险识别与分析的重要组成部分,在工程设计阶段应对整个工程各阶段的风险因素及其相互演化关系进行分析,并制定应对措施.     

Comparison of SETAM with security use case and security misuse case: A software security testing study

A software security testing behavior model,SETAM,was proposed in our previous work as the integrated model for describing software security testing requirements behavior,which is not only compatible with security functions and latent typical misuse behaviors,but also with the interaction of them.In this paper,we analyze the differences between SETAM with security use case and security misuse case in different types of security test requirements.To illustrate the effectiveness of SETAM,we compare them in a practical case study by the number of test cases and the number of faults detected by them.The results show that SETAM could decrease about 34.87% use cases on average,and the number of faults detected by SETAM increased by 71.67% in average,which means that our model can detect more faults with fewer test cases for software security testing.