Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

海上要地防空反导阵地优度排序研究

针对海上要地防空反导作战中发射阵地优度排序问题,结合要地面积较小、各备选阵地自然环境条件差别不大的实际情况,提出一种以各阵地与保卫目标间距离来衡量阵地优度的评价指标体系构建方法。首次将各己方目标的重要度作为对应评价指标的权值,并提出一种基于网页排名(PageRank, PR)算法的评价指标赋权方法。通过算例仿真可得,本文提出的方法能够给出科学、准确的备选阵地优度排序,为解决海上要地防空反导阵地选择问题提供了一种新思路、新方法。     

Bidirectional Feedback Dynamic Particle Filter with Big Data for the Particle Degeneracy Problem

Particle Filter(PF) is a data assimilation method to solve recursive state estimation problem which does not depend on the assumption of Gaussian noise, and is able to be applied for various systems even with non-linear and non-Gaussian noise. However, while applying PF in dynamic systems, PF undergoes particle degeneracy,sample impoverishment, and problems of high computational complexity. Rapidly developing sensing technologies are providing highly convenient availability of real-time big traffic data from the system under study like never before. Moreover, some sensors can even receive control commands to adjust their monitoring parameters. To address these problems, a bidirectional dynamic data-driven improvement framework for PF(B3 DPF) is proposed.The B3 DPF enhances feedback between the simulation model and the big traffic data collected by the sensors,which means the execution strategies(sensor data management, parameters used in the weight computation,resampling) of B3 DPF can be optimized based on the simulation results and the types and dimensions of traffic data injected into B3 DPF can be adjusted dynamically. The first experiment indicates that the B3 DPF overcomes particle degeneracy and sample impoverishment problems and accurately estimates the state at a faster speed than the normal PF. More importantly, the new method has higher accuracy for multidimensional random systems.In the rest of experiments, the proposed framework is applied to estimate the traffic state on a real road network and obtains satisfactory results. More experiments can be designed to validate the universal properties of B3 DPF.     

环境污染时生物种群的控制问题

本文研究一类受环境污染的单种群系统．本文将毒素输入率作为控制变量，研究线性化单种群系统的最小范数控制问题，给出了一个单种群系统最小范数控制元的存在性定理．     

具有等固有频率的系统主振型的统一求法

关于具有等固有频率的系统的主振型问题,初学者多感到困惑难懂;而迄今为止,几乎国内所有的振动专著,对此问题都未从理论上透彻阐述.本文从理论上系统地、透彻地讨论了这一问题,并论证了一个求相应主振型的统一公式.     

警用脉冲防暴水炮实验系统设计

基于现有实验设备，搭建了科学合理的脉冲防暴水炮试验系统，对其它水炮类装备的实验设计起到了指导作用。     

浅谈高等数学中的化归思想

化归思想贯穿于高等数学全部内容，是主要的数学思想方法，文章介绍了化归思想的含义。并阐述了化归思想在高等数学的应用及其在教学过程中如何渗透。     

The Function and Development of Soybean Peptides

Soybean peptides are small molecules hydrolyzed soy protein, from three to six amino acid composition of the peptide mixture, inl000Da molecular weight below.Because it has a lot of good physical and chemical properties and physiological functions, in many areas has been widely used. This paper reviews the soybean peptide physical and chemical characteristics, physiological functions, technology and applications in the food industry.     

基于MALAB的车牌定位算法研究

利用Matlab工具实现车牌定位算法研究。利用灰度修正，滤波和图像增强等预处理方法。较好地消除了图像的噪音，提高了图像质量。通过对车牌特征的研究，利用边缘检测和扫描方法实现车牌定位。