Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

海上要地防空反导阵地优度排序研究

针对海上要地防空反导作战中发射阵地优度排序问题,结合要地面积较小、各备选阵地自然环境条件差别不大的实际情况,提出一种以各阵地与保卫目标间距离来衡量阵地优度的评价指标体系构建方法。首次将各己方目标的重要度作为对应评价指标的权值,并提出一种基于网页排名(PageRank, PR)算法的评价指标赋权方法。通过算例仿真可得,本文提出的方法能够给出科学、准确的备选阵地优度排序,为解决海上要地防空反导阵地选择问题提供了一种新思路、新方法。     

Bidirectional Feedback Dynamic Particle Filter with Big Data for the Particle Degeneracy Problem

Particle Filter(PF) is a data assimilation method to solve recursive state estimation problem which does not depend on the assumption of Gaussian noise, and is able to be applied for various systems even with non-linear and non-Gaussian noise. However, while applying PF in dynamic systems, PF undergoes particle degeneracy,sample impoverishment, and problems of high computational complexity. Rapidly developing sensing technologies are providing highly convenient availability of real-time big traffic data from the system under study like never before. Moreover, some sensors can even receive control commands to adjust their monitoring parameters. To address these problems, a bidirectional dynamic data-driven improvement framework for PF(B3 DPF) is proposed.The B3 DPF enhances feedback between the simulation model and the big traffic data collected by the sensors,which means the execution strategies(sensor data management, parameters used in the weight computation,resampling) of B3 DPF can be optimized based on the simulation results and the types and dimensions of traffic data injected into B3 DPF can be adjusted dynamically. The first experiment indicates that the B3 DPF overcomes particle degeneracy and sample impoverishment problems and accurately estimates the state at a faster speed than the normal PF. More importantly, the new method has higher accuracy for multidimensional random systems.In the rest of experiments, the proposed framework is applied to estimate the traffic state on a real road network and obtains satisfactory results. More experiments can be designed to validate the universal properties of B3 DPF.     

环境污染时生物种群的控制问题

本文研究一类受环境污染的单种群系统．本文将毒素输入率作为控制变量，研究线性化单种群系统的最小范数控制问题，给出了一个单种群系统最小范数控制元的存在性定理．     

具有等固有频率的系统主振型的统一求法

关于具有等固有频率的系统的主振型问题,初学者多感到困惑难懂;而迄今为止,几乎国内所有的振动专著,对此问题都未从理论上透彻阐述.本文从理论上系统地、透彻地讨论了这一问题,并论证了一个求相应主振型的统一公式.     

库容有限且有批量折扣的不允许缺货存贮模型

Ｗｉｌｓｏｎ公式隐含着用户仓库容量足够大，单价与订购批量无关的假设，这一假设往往与实际情况相悖。为此，本文提出了仓库容量有限且有批量折扣条件下不允许缺货存贮模型，并通过实例说明了模型的应用。     

二能级原子与双模腔场的喇曼相互作用

研究了单个二能级原子与双模辐射腔场的喇曼相互作用，计算了原子的辐射谱，讨论了双模腔场处于不同数态时辐射谱的新特点     

一种参数闭环辨识方法在裁木系统中的应用

根根裁木系统的负载阶段性变化的特性,本文介绍了在设计中利用对象实际输出与期望输出之差来实现对对象参数闭环辨识的方法,使用该方法可有效地解决变动负载下的系统准确控制问题。在此基础上实现了裁木系统的微机自动控制。实验结果表明,理论设计是可行的,系统工作是可靠的,控制效果是满足技术要求的。     

ZG45钢表面激光熔凝处理及其热分析

用ＪＧ－２型脉冲激光机，对ＺＧ４５钢进行表面熔凝处理，熔凝区可以得到极细 的马氏体组织，其硬度可达到 ＨＶ８００以上。对激光熔凝处理过程的热分析表明：熔 区表面的升温和冷却速度极快，均在１０５数量级以上。一般情况下，ＺＧ４５钢的临界 淬火速度约为５０００℃／ｓ．热分析的计算结果与试验听得金相组织相符。