排序方式: 共有26条查询结果,搜索用时 203 毫秒
21.
22.
23.
Han MH Hwang SI Roy DB Lundgren DH Price JV Ousman SS Fernald GH Gerlitz B Robinson WH Baranzini SE Grinnell BW Raine CS Sobel RA Han DK Steinman L 《Nature》2008,451(7182):1076-1081
Understanding the neuropathology of multiple sclerosis (MS) is essential for improved therapies. Therefore, identification of targets specific to pathological types of MS may have therapeutic benefits. Here we identify, by laser-capture microdissection and proteomics, proteins unique to three major types of MS lesions: acute plaque, chronic active plaque and chronic plaque. Comparative proteomic profiles identified tissue factor and protein C inhibitor within chronic active plaque samples, suggesting dysregulation of molecules associated with coagulation. In vivo administration of hirudin or recombinant activated protein C reduced disease severity in experimental autoimmune encephalomyelitis and suppressed Th1 and Th17 cytokines in astrocytes and immune cells. Administration of mutant forms of recombinant activated protein C showed that both its anticoagulant and its signalling functions were essential for optimal amelioration of experimental autoimmune encephalomyelitis. A proteomic approach illuminated potential therapeutic targets selective for specific pathological stages of MS and implicated participation of the coagulation cascade. 相似文献
24.
J L Popot R A Demel A Sobel L L van Deenen J P Changeux 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,285(9):1005-1008
The interaction of the cholinergic (nicotinic) receptor protein purified from Torpedo marmorata electric organ with lipidic monomolecular films is studied at constant film area or constant superficial pressure. In both experimental situations, it is incorporated more efficiently into cholesterol than into egg lecithin films without showing any selectivity for a particular phospholipid class. 相似文献
25.
Nucleation by elastin 总被引:1,自引:0,他引:1
26.