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Rina Singer M. Sagiv B. Landau D. Allalouf E. Segenreich C. Servadio 《Cellular and molecular life sciences : CMLS》1980,36(5):578-579
Summary Motility and vitality of spermatozoa from semen differing in sperm density were assessed at various intervals after ejaculation. Percentile decreases in both parameters were found to be higher in oligospermic specimens than in those with higher sperm densities. 相似文献
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Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes 总被引:14,自引:0,他引:14
The intrathymic differentiation process by which precursor cells derived from the bone marrow develop into immuno-competent T lymphocytes is poorly understood. Most thymocytes express both CD4 and CD8 accessory molecules, yet little is known about either the function of these molecules or the responsiveness of the CD4+8+ double positive thymocytes that bear them. Here, we address the possibility that CD4 engagement influences T-cell receptor (TCR) expression on developing thymocytes. We engaged CD4 molecules on murine thymocytes by in vivo injection of an anti-CD4 monoclonal antibody, which reduced the surface expression of CD4 on CD4+ thymocytes. More importantly, CD4 engagement also affected TCR expression on CD4+ thymocytes, but the effect on CD4+8+ double positive and CD4+8- single positive thymocytes was very different. CD4+8+ thymocytes responded to CD4 engagement by dramatically increasing surface expression of TCR, whereas CD4+8- thymocytes decreased surface expression of TCR. These results demonstrate that the effect of CD4 engagement on TCR expression is dependent upon the developmental state of the responding thymocyte, and, most interestingly, results in increased TCR expression by double positive thymocytes. 相似文献
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Movements in the myelin Schwann sheath of the vertebrate axon 总被引:5,自引:0,他引:5
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The effects of elk ( Cervus elaphus ), pronghorn ( Antilocapra americana ), and mule deer ( Odocoileus hemionus ) browsing on shrubs in big sagebrush ( Artemisia tridentata ) communities were monitored over a 31-year period in Yellowstone National Park. Ungulates were restricting Wyoming big sagebrush (spp. wyomingensis ) heights, size, and recruitment on the lower-elevation stratum only, while no such suppression was observed on the high-elevation stratum. Parallel increases in mountain big sagebrush (spp. vaseyana ) densities and cover occurred over the study period on both browsed and unbrowsed sites at the higher-elevation stratum, although big sagebrush, green rabbitbrush ( Chrysothamnus viscidiflorus ), and horsebrush ( Tetradymia canescens ) were slightly taller and crown sizes were slightly larger on unbrowsed than browsed sites. Wyoming big sagebrush utilization (percent leader use) was eight times higher ( ̄ x = 87 ± 7.2% by pronghorns, mule deer, and elk) on the low-elevation winter ranges stratum (the Boundary Line Area [BLA] portion of the winter range), while mostly mountain big sagebrush with leader use averaged only 11 ± 4.1% (nearly all by elk) on the high-elevation range stratum. In addition, annual aboveground biomass production of big sagebrush did not differ between browsed and unbrowsed study sites on the high-elevation stratum of the winter range. Population turnover was higher on browsed plots versus unbrowsed plots. No difference was observed in percent dieback of big sagebrush adult plants between browsed and unbrowsed plots at the higher stratum. Browsing did not influence the number of leaves or seedstalks per plant ( P > .05), but leaves averaged 45% longer and seedstalks 42% longer on browsed big sagebrush. Ungulate browsing, however, apparently suppressed production, germination, and survival of Wyoming big sagebrush on the low-elevation stratum. Numbers of Wyoming big sagebrush declined 43% and cover declined 29%, 1957-1990, on browsed sites on the BLA. Annual biomass production on browsed sites at the low-elevation stratum was only 6-35% that of unbrowsed sites, and big sagebrush recruitment was less on browsed sites. Percent leader use of big sagebrush did not differ between the period of ungulate reductions, 1962-1969, and the 1980s on the lower stratum ( ̄ x = 87% leader use), but utilization was less on higher portions of the winter range during the period of elk reductions ( ̄ x = 2%) than during the 1980s following cessation of elk controls ( ̄ x = 11%). 相似文献
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The central dogma of molecular biology - DNA makes RNA makes proteins - is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work. 相似文献