Growth potential of human hepatocarcinoma cells in the liver of neonatal immunocompetent mice and its relation to immunological tolerance

To determine the pathological behavior of human hepatocarcinoma cells in the liver microenvironment of neonatal non-immunode-ficient mice, three human hepatocarcinoma cell lines (Bel7402, HepG2, and SK-Hep-1), traced by DiI, were transplanted into the intrahepatic or subcutaneous tissue of neonatal and adult Kunming mice. Histopathological observations showed that cells in the adult liver induced a severe immune response as early as the second day after the implantation, while the subcutaneous neoplasm underwent extensive necrosis by the end of the study. Only the cells injected into the neonatal liver underwent a delayed immunologic rejection in the organ microenvironment. These cells retained recognizable tumor features over the first seven days, and displayed an intrahepatic invasive pattern. The expression of tumor markers including alpha-fetoprotein and survivin was maintained. The quantitative ELISA for the expression patterns of IL-2 and IL-10 also confirmed that the intrahepatic immunity was non-susceptive during this period. The high serum alpha-fetoprotein level was inversely correlated with the change in immune response. Our study provided a bio-system for the research of immune responses to xenografts in the liver.     

Detection of dynamic brain networks modulated by acupuncture using a graph theory model

Neuroimaging studies involving acute acupuncture manipulation have already demonstrated significant modulatory effects on wide limbic/paralimbic nuclei, subcortical gray structures and the neocortical system of the brain. Due to the sustained effect of acupuncture, however, knowledge on the organization of such large-scale cortical networks behind the active needle stimulation phase is lacking. In this study, we originally adopted a network model analysis from graph theory to evaluate the functional connectivity among multiple brain regions during the post-stimulus phase. Evidence from our findings clearly supported the existence of a large organized functional connectivity network related to acupuncture function in the resting brain. More importantly, acupuncture can change such a network into a functional state underlying both pain perception and modulation, which is exhibited by significant changes in the functional connectivity of some brain regions. This analysis may help us to better understand the long-lasting effects of acupuncture on brain function, as well as the potential benefits of clinical treatments.     

保护卡在机房管理中的应用

高校计算机实验室承担着重要的实验教学任务,所以科学高效的管理就成为正常教学的保证.本文从实际应用的角度出发,简单介绍了在机房管理工作中如何科学使用保护卡以达到高效管理的目的,并辅助以实例具体阐述了相关内容.     

农村教师专业化素质的特殊要求

农村教师劳动既具有教师劳动的一般特点,又具有其劳动的特殊性,突出表现为教师劳动的多面性、独立性和艰苦性。由此对农村教师专业化素质提出了特殊要求,主要是热爱农村教育、关爱农村学生的教师职业道德;"一专多能"的教师知识和能力,特别是适应农村教学工作需要的学科专业知识和技能,以及创新能力;更需要有为农村教育事业"捧着一颗心来,不带半根草去"的献身精神。     

大超篮球联赛对校园文化建设的影响分析

本文对大超篮球联赛(中国大学生男子篮球超级联赛)所带来的校园体育文化建设的问题进行了探析,并对校园体育文化的内涵、价值及作用进行了阐述.校园体育文化是校园文化的重要组成部分,是实施素质教育的重要途径.大超篮球联赛既丰富了校园文化的内容,并促进校园体育文化的发展,对构建和谐校园也具有重要意义.     

沥青混凝土路面摊铺找平方式探讨

介绍了沥青混凝土摊铺的基本要求、准备工作,对摊铺机各部件的工作原理、找平方式进行了叙述,给施工操作提供了一些具体方法,以提高沥青混凝土的摊铺质量.     

聚合物降解与稳定化

文章通过对聚合物降解现象、导致降解的因素及降解机理的阐述,提出了防止聚合物降解即对聚合物进行稳定化所采用的物理及化学方法.     

浅谈林场职工思想政治教育工作

对于林杨职工来说,构建和谐的人际关系,既是构建社会主义和谐社会的必然要求,同时也为新时期林场恩想政治工作指明了目标和方向。     

川西北高原野生垂穗披碱草居群穗部形态研究

对分布于川西北高原的12个垂穗披碱草（Elymus nutans）种群的15个穗部形态性状进行了研究。Shannon-weaver指数分析表明,12个种群穗部形态学性状上具有丰富的遗传多样性(H′=1．86748),且遗传多样性主要集中在种群内部（71．91%）大于种群间遗传变异（28．09%）;聚类分析把12种群的材料聚为4类;主成分分析表明小穗宽、小穗长、外稃长、内稃长、穗长、单穗重和穗节数是造成12个种群垂穗披碱草穗部特征差异的主要因素。     

矩形管成品拉拔的芯头工作带设计与变形平滑化

分析矩形管带芯头拉拔工艺实质和变形平滑化机理,提出"以小变形量控制矩形截面管坯均匀的从模具工作带挤压出来"的拉拔平滑化方法.建立了带芯头拉拔工艺简化的三维运动模型及弹塑性有限元模拟模型,采集矩形长边中点、短边中点、圆角中点三个研究的关键点,分析获得直线型与带台阶型两种方案关键点的等效塑性应变和接触应力变化规律.在表面质量最难以保证的长边中点,带台阶方案的等效塑性应变较直线型芯头提高45.5%,其接触应力由0提高到13 MPa.采用带台阶型的芯头工作带拉拔,获得"一拉二压"的应力状态,以少量挤压变形调控壁厚偏差、提高矩形管材内外表面质量.