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11.
Danielle Kamato Muhamad Ashraf Rostam Rebekah Bernard Terrence J. Piva Nitin Mantri Daniel Guidone Wenhua Zheng Narin Osman Peter J. Little 《Cellular and molecular life sciences : CMLS》2015,72(4):799-808
G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier. 相似文献
12.
Theory and controls parameters affecting the output pressure and flow rate of the packed-bed electroosmotic pump (p-EOP), including zeta potential ζ, electric intensity E, length of the column L, cross-section area of the column A, dielectric constant ε and viscosity coefficient η of the liquid being pumped, are discussed concisely. And also, the fabrication and application of the p-EOP are introduced. 相似文献
13.
LuJian-ke 《武汉大学学报:自然科学英文版》2004,9(1):1-5
The homogeneous quadratic Riemann boundary value problem (1) with Hoelder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained. 相似文献
14.
Abrupt climate change:Debate or action 总被引:4,自引:1,他引:3
CHENGHai 《科学通报(英文版)》2004,49(18):1997-2002
Global abrupt climate changes have been documented by various climate records, including ice cores, ocean sediment cores, lake sediment cores, cave deposits, loess deposits and pollen records. The climate system prefers to be in one of two stable states, i.e. interstadial or stadial conditions, but not in between. The transition between two states has an abrupt character. Abrupt climate changes are, in general, synchronous in the northern hemisphere and tropical regions. The timescale for abrupt climate changes can be as short as a decade. As the impacts may be potentially serious, we need to take actions such as reducing CO2 emissions to the atmosphere. 相似文献
15.
RAOLan-lan CAIDong-han 《武汉大学学报:自然科学英文版》2004,9(4):404-406
We prove that the model with physical and human capital adjustment costs has optimal solution when the production function is increasing return and the structure of vetor fields of the model changes substantially when the prodution function from decreasing return turns to increasing return. And it is shown that the economy is improved when the coefficients of adjustment costs become small. 相似文献
16.
李淑琴 《科技情报开发与经济》2004,14(11):293-294
从测量、地质、钻探、煤矿三大害、煤质成果、地质资料评价等方面阐述了地质资料对煤矿生产的重要性,指出对地质资料的再认识,就是为了将地质资料去粗取精,确定其中能够为我所用的部分,以更好地为生产服务,并在矿区做下一步勘探工作时能够有的放矢,以最少的资金投入,达到最佳目的。 相似文献
17.
现阶段高校就业指导队伍建设 总被引:6,自引:1,他引:5
孙树枫 《浙江科技学院学报》2002,14(3):56-59
讨论了高校大学生就业指导工作现状,对就业指导师资体系进行了研究,提出了现阶段就业指导队伍建设的基本框架。 相似文献
18.
高淑云 《上饶师范学院学报》2002,22(4):63-65
私营企业是党的建设的重要领域,私营企业中的党组织如何正确处理与企业主的关系,是目前党建工作中的一个薄弱环节,也是迫切需要研究探索的一个重要课题,本文积极探索,寻求这方面的路径及规律。 相似文献
19.
20.
本文从我国高等教育大众化过程中引发的问题入手,提出了高校应积极采取的对策和措施,主要有:加强教学建设;深化教育改革;调整专业结构;提高高校毕业生就业率等。 相似文献