对基本对易关系式佯谬的讨论

对量子力学的基本关系式［ｘ·ｐｘ］＝ｉｈ在取迹时两边不相等的佯谬问题进行较系统的讨论，以便更好地进行教学     

Progenitor cell maintenance requires numb and numblike during mouse neurogenesis

Neurons in most regions of the mammalian nervous system are generated over an extended period of time during development. Maintaining sufficient numbers of progenitors over the course of neurogenesis is essential to ensure that neural cells are produced in correct numbers and diverse types. The underlying molecular mechanisms, like those governing stem-cell self-renewal in general, remain poorly understood. We report here that mouse numb and numblike (Nbl), two highly conserved homologues of Drosophila numb, play redundant but critical roles in maintaining neural progenitor cells during embryogenesis, by allowing their progenies to choose progenitor over neuronal fates. In Nbl mutant embryos also conditionally mutant for mouse numb in the nervous system, early neurons emerge in the expected spatial and temporal pattern, but at the expense of progenitor cells, leading to a nearly complete depletion of dividing cells shortly after the onset of neurogenesis. Our findings show that a shared molecular mechanism, with mouse Numb and Nbl as key components, governs the self-renewal of all neural progenitor cells, regardless of their lineage or regional identities.     

灰色线性规划及解的探讨

灰色线性规划（GLP）是研究不确定性决策问题的一种灰色系统分析方法,它是传统线性规划（TLP）方法的一个发展,GLP方法的应用主要依赖于它的解处理的可行性,以前的方法主要是通过定义和测试“可信度”来求解,本文给出了解漂移型灰色线性规划的一种新方法。     

移动卫星通信星座工程设计

在考虑许多的约束条件的情况下,研究了一个工程上可实现的轨道和星座设计方法。详细分析了移动卫星通信星座在工程设计时,就轨道参数、星座参数选择时所需考虑的在星体指标、通信要求、覆盖性能、发射及测控、经济等方面的约束条件,并进行综合考虑和优化设计。在此基础上,给出了一个星座通信系统的空间段设计,经专家评审该星座方案在工程实现上是可行的。     

川东高陡构造成因地质模式与含气性分析

川东高陡构造位于四川盆地东部 ,由一系列 NE-NNE向的隔档式褶皱组成。其构造变形经历了由隔槽式褶皱到“两背一断”,最终形成隔挡式褶皱的演化过程。在“两背一断”先存构造研究基础上 ,按继承发展的观点 ,综合运用伸展构造、反转构造、断层相关褶皱等构造新理论 ,系统探讨了川东高陡构造形成演化的成因地质模式 ,结合志留系主力生烃层的生气高峰期 ,对地腹不同成因类型的构造圈闭含气性进行了分析。     

CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing

To maintain genome stability, DNA replication is strictly regulated to occur only once per cell cycle. In eukaryotes, the presence of 'licensing proteins' at replication origins during the G1 cell-cycle phase allows the formation of the pre-replicative complex. The removal of licensing proteins from chromatin during the S phase ensures that origins fire only once per cell cycle. Here we show that the CUL-4 ubiquitin ligase temporally restricts DNA-replication licensing in Caenorhabditis elegans. Inactivation of CUL-4 causes massive DNA re-replication, producing cells with up to 100C DNA content. The C. elegans orthologue of the replication-licensing factor Cdt1 (refs 2, 3) is required for DNA replication. C. elegans CDT-1 is present in G1-phase nuclei but disappears as cells enter S phase. In cells lacking CUL-4, CDT-1 levels fail to decrease during S phase and instead remain constant in the re-replicating cells. Removal of one genomic copy of cdt-1 suppresses the cul-4 re-replication phenotype. We propose that CUL-4 prevents aberrant re-initiation of DNA replication, at least in part, by facilitating the degradation of CDT-1.     

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

Extracellular ATP is implicated in numerous sensory processes ranging from the response to pain to the regulation of motility in visceral organs. The ATP receptor P2X3 is selectively expressed on small diameter sensory neurons, supporting this hypothesis. Here we show that mice deficient in P2X3 lose the rapidly desensitizing ATP-induced currents in dorsal root ganglion neurons. P2X3 deficiency also causes a reduction in the sustained ATP-induced currents in nodose ganglion neurons. P2X3-null mice have reduced pain-related behaviour in response to injection of ATP and formalin. Significantly, P2X3-null mice exhibit a marked urinary bladder hyporeflexia, characterized by decreased voiding frequency and increased bladder capacity, but normal bladder pressures. Immunohistochemical studies localize P2X3 to nerve fibres innervating the urinary bladder of wild-type mice, and show that loss of P2X3 does not alter sensory neuron innervation density. Thus, P2X3 is critical for peripheral pain responses and afferent pathways controlling urinary bladder volume reflexes. Antagonists to P2X3 may therefore have therapeutic potential in the treatment of disorders of urine storage and voiding such as overactive bladder.     

基于形状描述直方图的声呐图像目标识别算法

针对水下声呐图像目标检测与识别问题,在图像规格化条件下,定义了几种不同的形状描述子,并统计计算描述子直方图,定义了几种不同的直方图匹配测度函数用以计算直方图间的相似性。分析了算法中关键参数的选取问题。仿真结果表明,基于该算法的识别率可达到98%以上,具有较强的不变性和鲁棒性。通过进一步信息融合算法可快速准确地实现水下声呐图像目标识别,具有较强的应用价值。     

基于RBF神经网络在线辨识的永磁同步电机单神经元PID矢量控制

提出一种基于RBF神经网络在线辨识的永磁同步电机单神经元PID矢量控制新方法,该方法针对传统的PI调节器固定参数所造成的不足,利用具有自适应能力的单神经元PID调节器和RBF神经网络相结合,实现了参数在线辨识,转速在线控制.仿真结果表明该方法控制精度高,动态特性好,适合于永磁同步电机的速度控制.     

W9Mo3Cr4V材料的低温热导率测量

通过试验测定了W9Mo3Cr4V材料在80K-300K的低温热导率,冷却介质采用液氮,试验采用稳态法,并使用中国科学院理化技术研究所的"金属材料低温热导测试装置".该试验数据精确度高,为高速钢刀具深冷处理的计算机模拟提供了必要的数据,同时填补了该材料低温参数的国内空白.