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排序方式: 共有103条查询结果,搜索用时 31 毫秒
51.
Hyerim Han Sang Hyeon Koh Bo Young Han Yeong Jin Chung Sang Chul Shin 《南京林业大学学报(自然科学版)》2010,34(4):175-175
以往研究认为,2006年前在韩国唯一的传播松材线虫的天牛是松褐天牛,但是最近的研究发现云杉花墨天牛也能传播松材线虫。对于两种天牛携带和传播线虫种类,特别是对拟松材线虫的携带和传播途径需要进一步研究。拟松材线虫分为欧洲型和东亚型,在韩国两种生物型都存在。笔者的研究表明大部分云杉花墨天牛携带的是欧洲型的拟松材线虫。 相似文献
52.
Kittichai Chaiseeda Shin A. Moteki D. Sahadeva Reddy Di Wu Kusumlata Chandra James M. Takacs 《复旦学报(自然科学版)》2005,44(5):631-632
We recently described a new combinatorial strategy for modular catalyst development, one using self-as-embly in the ligand scaffold-generating step to produce libraries of chiral self-assembled ligands. Metal-directed self-assembly of bifunetional subunits around a structural metal (typically zinc) can be used to form a heteroleptic complex in which a second set of ligating groups are suitably disposed to form a heterobimetallie cata- lyst system. See Fig. 1 相似文献
53.
Se-Yong Song Sang-Wook Yeh Soon-Il An Jong-Seong Kug Seung-Ki Min Seok-Woo Son Jongsoo Shin 《科学通报(英文版)》2022,(2):213-222
Understanding the regional hydrological response to varying CO2 concentration is critical for cost-benefit analysis of mitigation and adaptation polices in the ... 相似文献
54.
Summary We have observed Nebenkern formations in mammotrophs of normal male rats. The ultrastructural appearance of these formations suggests that they may be part of a mechanism which by the process of autophagy disposes of older prolactin granules. 相似文献
55.
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity 总被引:2,自引:0,他引:2
Gack MU Shin YC Joo CH Urano T Liang C Sun L Takeuchi O Akira S Chen Z Inoue S Jung JU 《Nature》2007,446(7138):916-920
Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, which contain a cluster of a RING-finger domain, a B box/coiled-coil domain and a SPRY domain, are involved in various cellular processes, including cell proliferation and antiviral activity. Here we report that the amino-terminal caspase recruitment domains (CARDs) of RIG-I undergo robust ubiquitination induced by TRIM25 in mammalian cells. The carboxy-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIG-I; this interaction effectively delivers the Lys 63-linked ubiquitin moiety to the N-terminal CARDs of RIG-I, resulting in a marked increase in RIG-I downstream signalling activity. The Lys 172 residue of RIG-I is critical for efficient TRIM25-mediated ubiquitination and for MAVS binding, as well as the ability of RIG-I to induce antiviral signal transduction. Furthermore, gene targeting demonstrates that TRIM25 is essential not only for RIG-I ubiquitination but also for RIG-I-mediated interferon- production and antiviral activity in response to RNA virus infection. Thus, we demonstrate that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic RIG-I signalling pathway to elicit host antiviral innate immunity. 相似文献
56.
苦杏仁脱苦去毒的最佳工艺条件探讨 总被引:3,自引:1,他引:2
通过正交试验法,对苦杏仁脱苦去毒的最佳工艺条件进行了选择。 相似文献
57.
58.
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile 总被引:1,自引:0,他引:1
Kilpeläinen TO Zillikens MC Stančákova A Finucane FM Ried JS Langenberg C Zhang W Beckmann JS Luan J Vandenput L Styrkarsdottir U Zhou Y Smith AV Zhao JH Amin N Vedantam S Shin SY Haritunians T Fu M Feitosa MF Kumari M Halldorsson BV Tikkanen E Mangino M Hayward C Song C Arnold AM Aulchenko YS Oostra BA Campbell H Cupples LA Davis KE Döring A Eiriksdottir G Estrada K Fernández-Real JM Garcia M Gieger C Glazer NL Guiducci C Hofman A Humphries SE Isomaa B Jacobs LC Jula A Karasik D Karlsson MK 《Nature genetics》2011,43(8):753-760
Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ~2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10(-6)) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10(-11)) and one near SPRY2 (P = 3 × 10(-8)). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance. 相似文献
59.
Vesicle budding and fusion underlies many essential biochemical deliveries in eukaryotic cells, and its core fusion machinery
is thought to be built on one protein family named soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE).
Recent technical advances based on site-directed fluorescence labelling and nano-scale detection down to the single-molecule
level rapidly unveiled the protein and the lipid intermediates along the fusion pathway as well as the molecular actions of
fusion effectors. Here we summarize these new exciting findings in context with a new mechanistic model that reconciles two
existing fusion models: the proteinaceous pore model and the hemifusion model. Further, we attempt to locate the points of
action for the fusion effectors along the fusion pathway and to delineate the energetic interplay between the SNARE complexes
and the fusion effectors.
Received 01 July 2008; received after revision 29 August 2008; accepted 23 September 2008 相似文献
60.
Cho YS Chen CH Hu C Long J Ong RT Sim X Takeuchi F Wu Y Go MJ Yamauchi T Chang YC Kwak SH Ma RC Yamamoto K Adair LS Aung T Cai Q Chang LC Chen YT Gao Y Hu FB Kim HL Kim S Kim YJ Lee JJ Lee NR Li Y Liu JJ Lu W Nakamura J Nakashima E Ng DP Tay WT Tsai FJ Wong TY Yokota M Zheng W Zhang R Wang C So WY Ohnaka K Ikegami H Hara K Cho YM Cho NH Chang TJ Bao Y Hedman ÅK Morris AP McCarthy MI;DIAGRAM Consortium;MuTHER Consortium Takayanagi R Park KS Jia W Chuang LM Chan JC Maeda S Kadowaki T Lee JY Wu JY 《Nature genetics》2012,44(1):67-72
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D. 相似文献