基于K-TOOLS的信息领航系统的研究

研究基于K-TOOLS的信息领航系统的前景以及此领航系统与其他信息领航系统之间的竞争优势与开发此领航系统的必要性.     

三个新大环草酰胺Ni(Ⅱ)配合物配体的合成、结构和DNA切割活性研究

合成了3个新的大环草酰胺Ni(Ⅱ)单核配合物NiL1(1),NiL2·CH3CH2OH(2)和NiL3·1.25H2O(3).由于羟基和草酰胺基团的氧原子都能够与金属离子配位,因此,NiL1-3可以用作构筑同多核和异多核配位化合物的配合物配体.X-射线单晶结构分析表明,每个大环配体的4个N原子与Ni(Ⅱ)配位,构成变形的平面正方形配位环境;Ni-N键的长度都非常短,表明3个大环配体中所有氮原子的配位能力都很强.1~3中的醇羟基使羟自由基淬灭,从而抑制了配合物切割DNA的活性.     

Construction and expression of retroviruses encoding dual drug resistance genes in human umbilical cord blood CD34+ cells

A series of retro viral vectors encoding humanmdr1 gene alone as wetl as in combination with either humanmgmt gene or human mutantSer ³¹-dhfr gene are engineered. The resultant retroviruses are used to transduce human umbilical cord blood CD34⁺ cetls. It has been shown that expression of dual drug resistance genes in transduced cetls confers a broad range of resistance to both kinds of corresponding drugs. These data suggest a rationale for the use of such double chemoresistance gene constructs in anin vivo model in which transduced hematopoietic cetls will acquire multiple protection against the cytotoxic side effects of combination chemotherapy and may have future application in chemoprotection of normal tissues, thus killing tumor cetls more effectivety.     

浅谈晶体管电路在继电保护中的应用

文章论述了晶体管电路在继电保护中的应用,分析了晶体管电路在现代电力系统中应用的优势及其发展趋势。     

纳米二氧化钛催化剂的制备及其光催化性能

利用酸催化的溶胶-凝胶(Sol—Gel)法制备了纳米二氧化钛半导体催化剂．用XRD,TEM技术对其结构进行了表征．并利用环己烷在其上的光催化氧化进行了结构与其催化性能关系的研究．结果表明：利用热处理技术可以制得不同粒径、不同相结构的纳米粒子;粒子粒度分布均匀,粒径分布范围窄;该纳米催化剂的光催化活性随粒子粒径的大小、相结构的不同而改变;催化剂对产物环己醇具有很高的选择性(选择性大于85％)．     

一种新型催化剂用于对硝基甲苯催化氢化的研究

制备了两种不同的含氮高分子-钯络合物,并研究了它们对对硝基甲苯的催化活性.结果发现,聚苯乙烯负载的苯乙烯-二乙烯基苯-马来酸酐交替共聚物与氨反应得到的高分子-钯络合物,在常温常压下对对硝基甲苯催化氢化有很高的活性,产物对甲苯胺的收率为100%.     

Enantioselective assay of S（＋）－ and R（－）－propafenone in human urine by using RP－HPLC with pre－column chiral derlvatization

The enantioselective assay for S(+)- and R(-)-propafenone (PPF) in human urine that developed in this work involves extraction of propafenone from human urine and using S(+)-propafenone as internal standard, chiral derivatization with 2,3,4,6-tetra-O-beta-D-glucopranosyl isothiocyanate, and quantitation by an RP-HPLC system with UV detection (lambda=220 nm). A baseline separation of propafenone enantiomers was achieved on a 5-microm reverse phase ODS column, with a mixture of acetic acid (25:12:0.02,v/v) as mobile phase. There was good linear relationship from 24.9 ng/ml to 1875.0 ng/ml for both of enantiomers. The regression equations of the standard curves based on C(S-PPF) (or C(R-PPF)) versus ratio of A(S-PPF)/A(S) (or A(R-PPF)/A(S)) were y=0.0032x-0.081, (r=0.999) for S-PPF and y=0.0033x+0.0039, (r=0.998) for R-PPF, respectively. The method's limit of detection was 12.5 ng/ml for both enantiomers, and the method's limit of quantitation was 28.2+/-0.52 ng/ml for S-PPF, 30.4+/-methanol:water:glacial 0.53 ng/ml for R-PPF (RSD<8%, n=5). The analytical method yielded average recovery of 98.9% and 100.4% for S-PPF and R-PPF, respectively. The relative standard deviation was no more than 6.11% and 6.22% for S-PPF and R-PPF, respectively. The method enabled study of metabolism of S(+)- and R(-)-propafenone in human urine. The results from 7 volunteers administered 150 mg racemic propafenone indicated that propafenone enantiomers undergo stereoselective metabolism and that in the human body, S(+)-propafenone is metabolized more extensively than R(-)-propafenone.     

基于时频分析的海洋激光探测信号检测与识别

针对机载海洋激光探测系统接收信号中噪声的非平稳性及与信号的相关性问题 ,利用信号的 Gabor展开在时间和频率域局部化信号的能力 ,对信号进行时频相关检测和分析 ,提出了一种基于时频分析的相关检测方法以及基于时频特性描述的信号分析和识别 .实验结果表明该方法是一种抗噪性能强 ,自适应性能好的弱信号检测与识别方法     

供应链关键绩效评价指标及优化

分析了供应链产品出产 (或投产 )循环期这一关键绩效评价指标 ,运用生产平准化的思想和循环排序的方法 ,建立了供应链产品出产 (或投产 )循环期数学模型 .该问题为 NP难题 .通过对该模型的研究 ,提出了优化这一关键绩效指标的启发式算法 .     

块状纳米材料的设计理论研究

在二元共晶Spinodal系统中 ,Spinodal波长的大小随过冷度的增加而减少 ,并存在一个最小的波长 ,此时合金的生长速度最快 .提出当过冷度足够大时 ,液态Spinodal的波长进入到纳米尺度 ,形成块状纳米材料 .由于液态的扩散较易发生 ,当波长为纳米量级时 ,Spinodal的转变时间为微秒量级 .由于液体表面张力等的影响 ,液态Spinodal的组织由网状变成微粒形态 .