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261.
PAN HuiJuan SHI FangLei CHANG ZongFei XIANG ZuoFu SUN TingTing LIU ZhiJin LIMing 《科学通报(英文版)》2011,56(24):2541-2544
Guizhou snub-nosed monkey (Rhinopithecus brelichi) is a unique, endangered primate in China, mainly distributed in Fanjing Mountain National Natural Reserve, Guizhou Province, in an area of 275 km2. Recently, habitat loss and fragmentation have caused population isolation. To assess genetic diversity within this species and its population structure, we sequenced 400 bp of the hypervariable I segment from the mitochondrial DNA control region for 128 individuals. Only one haplotype was identified from these individuals. Compared with other primate species, R. brelichi can be regarded as a species with very low genetic diversity, which further adds to the conservation concern. 相似文献
262.
Yong Wei QiuGang Zong ZuYin Pu WeiXing Wan JianJun Liu SuiYan Fu QuanQi Shi 《科学通报(英文版)》2011,56(11):1117-1122
It is believed that a southward interplanetary magnetic field (IMF) is mainly responsible for the energy input from solar
wind into the magnetosphere. This paper presents an unusual case of strong anti-sunward plasma flow (up to 2 km/s) in the
polar cap ionosphere and large cross-polar cap potential (CPCP) during a period of horizontal IMF (|B
Z
| < 2 nT) observed by both ACE (at the L1 point) and Geotail (on the dusk flank of the magnetosheath). The CPCP is even higher
than that under preceding B
Z
≈ −23 nT. Furthermore, GOES8 observed that the magnetosheath field turns northward as the anti-sunward plasma flow and CPCP
start to increase, which implies that the magnetosheath field interacting with the Earth’s magnetopause has significantly
rotated and differs from the IMF observed by ACE and Geotail. In accordance with previous theoretical work, we suggest that
the magnetic field line draping produces a southward magnetosheath field and enhances anti-sunward plasma flow and the CPCP. 相似文献
263.
HongQiang Yan KeFu Yu Qi Shi YeHui Tan HuiLing Zhang MeiXia Zhao Shu Li TianRan Chen LingYing Huang PinXian Wang 《科学通报(英文版)》2011,56(7):676-684
Field measurements of air-sea CO2 exchange in three coral reef areas of the South China Sea (i.e. the Yongshu Reef atoll of the Nansha Islands, southern South China Sea (SCS); Yongxing Island of Xisha Islands, north-central SCS; and Luhuitou Fringing Reef in Sanya of Hainan Island, northern SCS) during the summers of 2008 and 2009 revealed that both air and surface seawater partial pressures of CO2 (pCO2) showed regular diurnal cycles. Minimum values occurred in the evening and maximum values in the morning. Air pCO2 in each of the three study areas showed small diurnal variations, while large diurnal variations were ob-served in seawater pCO2. The diurnal variation amplitude of seawater pCO2 was ~70 μmol mol–1 at the Yongshu Reef lagoon, 420–619 μmol mol–1 on the Yongxing Island reef flat, and 264–579 μmol mol–1 on the reef flat of the Luhuitou Fringing Reef, and 324–492 μmol mol–1 in an adjacent area just outside of this fringing reef. With respect to spatial relations, there were large differences in air-sea CO2 flux across the South China Sea (e.g. ~0.4 mmol CO2 m–2 d–1 at Yongshu Reef, ~4.7 mmol CO2 m–2 d–1 at Yongxing Island, and ~9.8 mmol CO2 m–2 d–1 at Luhuitou Fringing Reef). However, these positive values suggest that coral reef ecosystems of the SCS may be a net source of CO2 to the atmosphere. Additional analyses indicated that diurnal variations of surface seawater pCO2 in the shallow water reef flat are controlled mainly by biological metabolic processes, while those of deeper water lagoons and outer reef areas are regulated by both biological metabolism and hydrodynamic factors. Unlike the open ocean, inorganic metabolism plays a significant role in influencing seawater pCO2 variations in coral reef ecosystems. 相似文献
264.
针对异常检测算法速度慢、精度低、稳定性差等问题,提出了一种通过异常概率排序提取异常点的算法(OAP).由于异常点相对正常点更容易通过对数据空间的均匀分割而孤立出来,所以OAP通过数据点在均匀N叉分割树中的孤立深度估算异常概率的大小,从而得到异常概率的排序,最终构造由k个异常概率最大的点组成的列表,列表中的数据就是所求的... 相似文献
265.
266.
267.
新定额的实施符合通信建设市场发展的要求,也激励着更多的施工企业投入到通信工程建设中来。通过对新定额的不断补充和完善,使新定额在工程实践中得到更合理的应用。 相似文献
268.
269.
为了探讨瑞香狼毒(Stellera chamaejasme)在植物源农药方面的应用,研究采用2.50k的瑞香狼毒根粉,95%乙醇总提取液浓缩至500mL,定为原液,按不同浓度稀释后,室内叶碟法杀灭菜粉蝶(Pieris rapae)4龄菜青虫试验结果显示:浓度为160mol/L时,4龄幼虫表现为高度的拒食现象.浓度为80... 相似文献
270.
Zuber J Shi J Wang E Rappaport AR Herrmann H Sison EA Magoon D Qi J Blatt K Wunderlich M Taylor MJ Johns C Chicas A Mulloy JC Kogan SC Brown P Valent P Bradner JE Lowe SW Vakoc CR 《Nature》2011,478(7370):524-528
Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. Although chromatin alterations are, in principle, reversible and often amenable to drug intervention, the promise of targeting such pathways therapeutically has been limited by an incomplete understanding of cancer-specific dependencies on epigenetic regulators. Here we describe a non-biased approach to probe epigenetic vulnerabilities in acute myeloid leukaemia (AML), an aggressive haematopoietic malignancy that is often associated with aberrant chromatin states. By screening a custom library of small hairpin RNAs (shRNAs) targeting known chromatin regulators in a genetically defined AML mouse model, we identify the protein bromodomain-containing 4 (Brd4) as being critically required for disease maintenance. Suppression of Brd4 using shRNAs or the small-molecule inhibitor JQ1 led to robust antileukaemic effects in vitro and in vivo, accompanied by terminal myeloid differentiation and elimination of leukaemia stem cells. Similar sensitivities were observed in a variety of human AML cell lines and primary patient samples, revealing that JQ1 has broad activity in diverse AML subtypes. The effects of Brd4 suppression are, at least in part, due to its role in sustaining Myc expression to promote aberrant self-renewal, which implicates JQ1 as a pharmacological means to suppress MYC in cancer. Our results establish small-molecule inhibition of Brd4 as a promising therapeutic strategy in AML and, potentially, other cancers, and highlight the utility of RNA interference (RNAi) screening for revealing epigenetic vulnerabilities that can be exploited for direct pharmacological intervention. 相似文献