Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy

Bone morphogenetic proteins (BMPs) are important extracellular cytokines that play critical roles in embryogenesis and tissue homeostasis. BMPs signal via transmembrane type I and type II serine/threonine kinase receptors and intracellular Smad effector proteins. BMP signaling is precisely regulated and perturbation of BMP signaling is connected to multiple diseases, including musculoskeletal diseases. In this review, we will summarize the recent progress in elucidation of BMP signal transduction, how overactive BMP signaling is involved in the pathogenesis of heterotopic ossification and Duchenne muscular dystrophy, and discuss possible therapeutic strategies for treatment of these diseases.     

杭州人工智能企业集群发展研究

基于人工智能技术、产品、服务对“人”“城市”“平台”的作用和影响,分析了杭州三类人工智能企业集群的发展情况和存在短板,提出对策建议。     

浅议工程施工成本控制方法

加强成本管理是市政施工企业提高管理水平、经济效益和持续稳定发展的重要保证,是直接涉及影响企业信誉和生存的关键因素,是需要我们实实在在地面对和解决的问题.     

感应式静电引信探测技术

目的　研究直接检测探测电极的感应电荷获得静电目标信息的静电近炸引信探测技术; 方法　采用短路轴向探测电极感应引信接近静电目标过程中电荷量的变化,并采用电荷放大器检测信号; 利用静电学的基本原理,对其进行了理论推导; 结果　得出探测方程和定距公式,以及增大探测灵敏度的设计准则; 阐述了在该种电极设置下对检测电路的要求以及环境变化对检测结果稳定性的影响; 结论　感应式静电引信探测技术适用于静电目标探测且探测距离远、不受非带电物体的干扰;     

压力下半导体GaAs的电子表面态

使用插值拟合近似获得晶格常数、带隙随压力的解析表示，采用变分法研究了流体静力学压力对半导体GaAs电子本征表面态的影响，数值结果表明，随压力增加电子表面态能级明显向上移动，且电子趋近表面。     

海子抒情诗中“秋”意象解析

海子诗歌意象丰富，意蕴深厚，极具艺术张力，例如“秋”意象。本文从三方面论述海子抒情诗中“秋”意象。首先，“秋”象征丰收而荒凉的人世；其次，论述“秋”的感伤；最后，“秋”是幻象丛生的国度。     

Design of the signal processor for an ionospheric sounding system

On the basis of the analysis of the system sounding principle, this paper introduced a new type of ionospheric oblique backscattering sound system, which is based on the pseudo- random noise phase modulated pulse compression. According to the high requirements of real-time and a large amount of computation and echo characteristics, a high-speed real-time signal processing system was established and the design of system hardware and software was focused on. The sounding results indicate that the system is equipped to handle the data fast and has a high degree of software features. It is of great significance for the realization of fast, real-time ionospheric sounding means.      

我国电子政务的发展与研究

目前,电子政务已成为世界许多国家和地区政府追求的目标和关注的焦点,我国的电子政务同样也得到了党和国家的高度重视,并成为国家信息化建设中极为重要的组成部分。本为首先介绍了我国电子政务的发展历程,然后经过深入研究总结出我国电子政务存在的问题,并提出相应的解决措施。     

钱谦益唐宋兼宗的祈向与清代诗风新变

“诗必盛唐”是明代具有强势传播力的诗学观念 ,其消极影响是法唐而赝 ,自狭诗道。当时虽有接纳宋诗的呼唤 ,但难以形成趋势。明末清初 ,钱谦益以唐宋兼宗为新的诗学选择 ,具体途辙是以崇尚杜诗为由唐向宋的起点 ,在诗坛大力导入宋代诗风 ,融铸异质 ,求变创新。以沉潜深厚改变浮薄肤浅 ,以性情为本取代唯务格调 ,从而形成宏衍阔大的气局 ,使诗歌创作具有多元组合的美质。钱氏的这一诗学选择开启了清代新诗风