关于人体模型处理技术的探究

选择VRML和Java3D技术处理三维人体模型,该方法不仅可以高效地支持人体模型的可视化,还支持基于三维人体模型的研究与应用.采用Java3D技术对三维人体模型进行处理,可成功地解决前人利用VRML技术开发系统所碰到的若干问题.     

Ag纳米线过热的热力学模型

对Ag纳米线的熔化和过热作了研究,提出了一种经典热力学模型对Ag纳米线的过热机制作了阐述;当考虑到低能Ag/Ni界面的作用时,推导了过热的定量表达式,说明了过热与纳米线的半径和界面能有密切关系.     

构建具有创新精神与实践能力的人才培养体系

构建创造型人才培养体系,需要改变教育观念,全面推进素质教育;重构教师培养体制;改革教师分配制度,形成激励机制;加大投入力度,扩大创新型人才培养的覆盖面;改革实验室建设和管理模式,不断探索培养创造型人才的有效途径。     

打造特色：培养“本科＋全能”型小学师资的行动策略——以石家庄学院为例

小学教育的实践领域对教师的素质提出了更高的要求,实施以特色求发展的创新举措,把培养＂本科＋全能＂型小学师资作为打造教师教育特色的战略主攻方向,有助于在日趋激烈的社会竞争中异军突起、独领风骚,向教育实践领域输送高水平教师方面有所作为并受到青睐,打造教师教育特色的工作才会如虎添翼。     

汤旺河干流水电站规划二氧化硫减排量的分析和计算

开发水电资源,可以替代火电,减少二氧化硫的排放量,为节能减排做出积极地贡献．根据汤旺河干流水电规划,尝试对规划实施后替代的二氧化硫减排量进行分析和计算．     

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Epigenetic pathways can regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes, and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. Although chromatin alterations are, in principle, reversible and often amenable to drug intervention, the promise of targeting such pathways therapeutically has been limited by an incomplete understanding of cancer-specific dependencies on epigenetic regulators. Here we describe a non-biased approach to probe epigenetic vulnerabilities in acute myeloid leukaemia (AML), an aggressive haematopoietic malignancy that is often associated with aberrant chromatin states. By screening a custom library of small hairpin RNAs (shRNAs) targeting known chromatin regulators in a genetically defined AML mouse model, we identify the protein bromodomain-containing 4 (Brd4) as being critically required for disease maintenance. Suppression of Brd4 using shRNAs or the small-molecule inhibitor JQ1 led to robust antileukaemic effects in vitro and in vivo, accompanied by terminal myeloid differentiation and elimination of leukaemia stem cells. Similar sensitivities were observed in a variety of human AML cell lines and primary patient samples, revealing that JQ1 has broad activity in diverse AML subtypes. The effects of Brd4 suppression are, at least in part, due to its role in sustaining Myc expression to promote aberrant self-renewal, which implicates JQ1 as a pharmacological means to suppress MYC in cancer. Our results establish small-molecule inhibition of Brd4 as a promising therapeutic strategy in AML and, potentially, other cancers, and highlight the utility of RNA interference (RNAi) screening for revealing epigenetic vulnerabilities that can be exploited for direct pharmacological intervention.     

Musielak-Orlicz-Sobolev空间关于Luxemburg范数的端点

本文着重讨论Musielak-Orlicz-Sobolev空间端点的性质,得到Musielak-Orlicz-Sobolev空间关于Luxemburg范数端点的充分条件.     

溶胶-凝胶法制备TiO_2/MCM-41负载型光催化剂及其性能表征

以钛酸丁酯为钛源、MCM-41分子筛为载体,采用溶胶-凝胶法制备TiO2/MCM-41负载型光催化剂,并通过XRD、BET、TEM、XPS对最佳条件下制备的光催化剂进行表征。结果表明,所制光催化剂是一种具有均匀规则孔道结构的介孔材料,其粉体比表面积高达358.8m2/g;经700℃煅烧,催化剂主要晶相为锐钛矿相。光催化剂中的Ti以+4价存在,TiO2表面羟基氧所占比率为38.0%。以水中甲基橙为模拟污染物,TiO2/MCM-41光催化剂对浓度为25mg/L的甲基橙溶液降解0.5h后,其脱色率为93.7%。     

初探地理国情普查与省级基础测绘的协同生产

本文主要讲述地理国情普查与基础测绘的主要技术工艺及其协同生产的方式方法。明确基础测绘与地理国情项目的区别与联系,在实际作业中突出重点、避免重复,可以事半功倍。     

雷击引发的变压器故障分析

某电厂一次雷击事故,造成两台变压器间隙击穿,其中一台变压器出现故障并出现变压器差动保护快速动作。通过检查现场信息以及分析故障前后的波形相关数据,得出匝间故障是造成本次差动保护动作的原因。通过对故障过程以及保护动作原因进行分析,本文提出了一些建议,对该类问题的分析与解决提供一定的参考。