基于频率的Read Mapping种子选择算法

选择具有最低频率的最优种子是一个复杂的计算问题,往往需要很长时间.提出了一种read的基于频率的合并种子选择算法(FMSS),该算法能够高效地选择接近最优的种子集合,可用于改善现有映射工具的性能.实验对比了平均种子选择方法和当前最优的种子选择策略(OSS,optimal seed solver),结果显示FMSS算法能够用很少的时间代价给出接近OSS的最优种子集合,这表明FMSS算法可集成到现有映射工具中用于处理更大规模的read mapping问题.     

Ion flux dropout observed near dipolarization front

An ion flux dropout near the dipolarization front （DF） at around XGSM =- 11 RE in the Earth＇ s plasma sheet was observed by Time History of Events and Macroscale Interaction during substorms （THEMIS） on March 31, 2009. The ion differential energy fluxes at energies from 450 eV to 150 keV measured by the ESA and SST instruments from THC began to decrease about 2 s before the detection of the DF and reached a local minimum 6 s later. Then, the ion fluxes gradually increased to form a dropout around the DF. The spatial extent of the dropout was about 4,000 km. For energies above 20 keV, the ion fluxes after the dropout are greater than those before it, contrary to the fluxes at energies below 20 keV. The associated ion density variation indicates that the ion flux dropout coincides with the ion density dropout. Taking advantage of multipoint observations, THD, THC, and THE detected the same DF consecutively. Only THC detected an obvious ion flux dropout; THD observed an indistinct one about 2 s before THC; no high-energy （E 〉 30 keV） ion flux dropout was observed by THE. Our study suggests that the ion flux dropout may evolve with the earthward-propagating DF, and its properties can depend on locations relative to the DF.     

系统论视角下我国农村水污染受害者救助的社区干预方法探析

支持性的社区环境可以为个人和家庭提供基本的社会、经济和情感的支持,而一个功能衰败、权力结构不平等的社区则会加深个人和家庭的功能失调和病态。本文以系统理论为基本工具,了解和介入案主的社会环境,探究我国农村水污染受害者救助社区干预方法。     

Benthic foraminiferal δ~(13)C minimum events in the southeastern Okhotsk Sea over the last 180 ka

A total of six d13C minimum events,i.e.,VI,V,IV,III,II,and I,were observed via a stable carbon and oxygen isotope analysis of infaunal benthic foraminifera Uvigerina spp.in gravity core OS03-1 in the southeastern Okhotsk Sea over the last 180 ka.These events occurred at112–109,102–90,85–76,57–54,44–40,and 17–10 ka BP.The largest negative excursions reached 2.5%in event V and were greater than 1%in the other events.We proposed that all d13C minimum events were caused by the increase in sea surface water productivity,the weakened formation of Okhotsk Sea intermediate water,and the enhancement of the oxygen minimum zone.The negative excursions were unaffected by methane hydrate destabilization and subsequent methane release based on the results obtained by using archaeal lipid markers.     

对合法有序语境下的网络监督思考

网络监督是以网民为主体,以互联网为平台,通过网络技术和各种网络形式对公共权力进行监督的方式。它需要加强网络系统的建设,建立部门齐全的法律相互协作,并协调网络政治参与和网络有序发展的关系,只有这样,才能提高网民的网络监督意识与能力。     

Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src

Apolipoprotein CIII (ApoCIII) not only serves as an inhibitor of triglyceride hydrolysis but also participates in diabetes-related pathological events such as hyperactivation of voltage-gated Ca²⁺ (Ca_V) channels in the pancreatic β cell. However, nothing is known about the molecular mechanisms whereby ApoCIII hyperactivates β cell Ca_V channels. We now demonstrate that ApoCIII increased Ca_V1 channel open probability and density. ApoCIII enhanced whole-cell Ca²⁺ currents and the Ca_V1 channel blocker nimodipine completely abrogated this enhancement. The effect of ApoCIII was not influenced by individual inhibition of PKA, PKC, or Src. However, combined inhibition of PKA, PKC, and Src counteracted the effect of ApoCIII, similar results obtained by coinhibition of PKA and Src. Moreover, knockdown of β1 integrin or scavenger receptor class B type I (SR-BI) prevented ApoCIII from hyperactivating β cell Ca_V channels. These data reveal that ApoCIII hyperactivates β cell Ca_V1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src.     

人影弹药安全存储报警装置研制

为解决基层人影作业点弹药安全存储问题,笔者开发研制了人影弹药安全存储报警装置,系统以三星ARM9 32位嵌入式RISC CPU S3C2410A处理器为硬件核心,根据报警装置需要实现的功能,添加适当的外围电路,主程序以嵌入式LINUX2.6.28作为操作系统而开发的具有远程报警、数据、监控画面上传等功能的报警系统。     

Transient pressure analysis for the reactor core and containment of a HTGR after a primary loop pressure boundary break accident

The pressure variances in the reactor core and containment of a High Temperature Gas-cooled Reactor (HTGR) after a primary loop pressure boundary break accident determine the structural integrity and safety of the reactor. Based on mass conservation, energy conservation and state equations, explicit formulae for the transient pressure and temperature variances in the pressure vessels were deduced, and a set of differential equations for the transient pressure and temperature variances in the containment were developed. Numerical simulation was also conducted to investigate the transient pressure and temperature variances in the pressure vessels and containment. The results show that energy transformation due to expansion work cannot be neglected. The maximum pressure in the containment could increase by 40 percent due to blockage caused by air in the containment. Detailed numerical simulations of the transient pressure and temperature variance in the reactor core flow passages were also conducted. The results show that the pressures acting on the reactor core and containment are below acceptable values.     

组网雷达探测能力的并行计算与可视化方法研究

深入研究了并行计算与并行绘制相结合的并行框架构建问题。针对组网雷达探测能力的计算与可视化特点,在(PC)集群的基础上,构建了一个并行计算与可视化运行框架。该框架在并行计算中,采用八叉树分割的方法对组网雷达计算区域进行任务分配；在并行绘制中,采用sort-last的并行绘制机制。仿真试验结果表明,该运行框架能够有效地满足大规模组网雷达探测能力计算与可视化的应用需要。