稀释气体对甲烷层流预混火焰燃烧速度的影响

基于GRI-Mech 3.0详细化学反应机理,利用预混燃烧模型(PREMIX Code)研究了甲烷-空气-稀释气层流预混火焰燃烧特性及火焰结构.重点探讨了不同化学当量比(0.5～1.5)、初始压力(0.05～0.40 MPa)、稀释气体种类(N2,CO2及H2O)和稀释摩尔比(0～0.35)对甲烷-空气-稀释气混合气层...     

多波段光度计定标及误差分析

摘要根据Langley法定标的原理,在河北省灵寿县对4台多波段太阳光度计MICROTOPSⅡ进行定标,并采用最小二乘法得到了很好的定标结果。分别计算了仪器的视场角、通道的半波宽度、大气状况以及气体吸收等方面对定标结果造成的影响,并且对水汽吸收通道（936nm）采用修正的Langley法定标,得到4台仪器各自5个通道的定...     

斑马鱼SAA基因克隆及表达分析

利用巢式PCR(nest PCR)的方法克隆斑马鱼血清淀粉样蛋白A基因,并进行生物信息学分析.实时荧光定量PCR结果显示:SAA在斑马鱼胚胎发育时期的表达量呈现明显的“增长—稳定—增长”趋势.成鱼组织分布中,SAA在11个斑马鱼组织中均能检测到,在心脏和肝脏中相对高表达.     

浅谈三段式电流保护

当线路发生短路故障时,重要特征之一是线路的电流急剧增大,当电流流过某一预定值时,反应于电流升高而动作的保护装置叫过流保护。而三段式电流保护具有作为主保护和后备保护的全部功能,在实际中得到广泛应用。     

浅谈我国铁路通信信号发展趋势

随着信息时代的到来,铁路的发展也在日新月异的变化着,铁路通信信号的发展趋势正在向一体化、多信息化、功能集成化、高度自动化的方向前进。文章主要从计算机联锁设备、列车自动控制系统、调度指挥系统三个部分对信号系统进行了分析和阐述。     

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response to natural and synthetic ligands. Recent crystal structures provide insights into inactive states of several GPCRs. Efforts to obtain an agonist-bound active-state GPCR structure have proven difficult due to the inherent instability of this state in the absence of a G protein. We generated a camelid antibody fragment (nanobody) to the human β(2) adrenergic receptor (β(2)AR) that exhibits G protein-like behaviour, and obtained an agonist-bound, active-state crystal structure of the receptor-nanobody complex. Comparison with the inactive β(2)AR structure reveals subtle changes in the binding pocket; however, these small changes are associated with an 11?? outward movement of the cytoplasmic end of transmembrane segment 6, and rearrangements of transmembrane segments 5 and 7 that are remarkably similar to those observed in opsin, an active form of rhodopsin. This structure provides insights into the process of agonist binding and activation.     

Crystal structure of the β2 adrenergic receptor-Gs protein complex

G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses to hormones and neurotransmitters as well as the senses of sight, olfaction and taste. The paradigm of GPCR signalling is the activation of a heterotrimeric GTP binding protein (G protein) by an agonist-occupied receptor. The β(2) adrenergic receptor (β(2)AR) activation of Gs, the stimulatory G protein for adenylyl cyclase, has long been a model system for GPCR signalling. Here we present the crystal structure of the active state ternary complex composed of agonist-occupied monomeric β(2)AR and nucleotide-free Gs heterotrimer. The principal interactions between the β(2)AR and Gs involve the amino- and carboxy-terminal α-helices of Gs, with conformational changes propagating to the nucleotide-binding pocket. The largest conformational changes in the β(2)AR include a 14 ? outward movement at the cytoplasmic end of transmembrane segment 6 (TM6) and an α-helical extension of the cytoplasmic end of TM5. The most surprising observation is a major displacement of the α-helical domain of Gαs relative to the Ras-like GTPase domain. This crystal structure represents the first high-resolution view of transmembrane signalling by a GPCR.     

喜鹊在山地次生林中鸟类群落组织结构形成的作用

通过山地次生林鸟类群落组织结构的研究,表明喜鹊在鸟类群落组织形成中是关键类群之一.关键类群是通过巢地资源的被利用来实现的.5年中,利用喜鹊巢繁殖的鸟类达5种,利用率为25%~40.7%.     

基于自适应形态学的跳频信号参数联合盲估计

跳频通信的应用大大提高了军事装备的抗干扰和抗截获能力,使得跳频对抗技术面临严峻的挑战。为解决传统形态学跳频信号参数估计方法中结构元素选择困难问题并提高估计精度,提出了一种基于自适应形态学的跳频信号参数联合盲估计方法。首先,对跳频信号进行短时傅里叶变换获取谱图。然后,从其时间轴投影中获取结构元素尺寸的知识, 设计自适应形态学滤波器抑制谱图噪声, 提取跳频图案初步估计跳频参数。最后, 引入最小二乘估计方法, 对跳频周期和跳变时刻进行精估计。仿真结果表明,此方法能够同时估计出跳频频率、跳频周期和跳变时刻, 不需要其中某一种参数作为先验条件, 在复杂的通信环境也能够保持良好的估计性能。     

基于特征选取与树状Parzen估计的入侵检测

针对目前网络空间安全形势快速变化带来的新风险和新挑战, 提出一种基于相关性分析的特征选取和树状Parzen估计优化的入侵检测方法。首先, 通过基于相关性分析的数据特征选取方法对数据维度进行压缩。其次, 对原始数据集进行特征筛选, 生成新的特征子集。最终, 使用序列模型优化算法中的树状Parzen估计算法对随机森林算法进行模型优化。实验结果表明, 相比其他应用机器学习算法的入侵检测方法, 所提方法在提升综合性能的同时拥有更高的检测效率, 有效地提升了入侵检测技术的实用性。