Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.     

神经网络自适应滤波器在故障诊断中的应用

分析了用自适应滤波器进行故障诊断的方法．针对该方法在计算上要花费大量时间、难于完成实时诊断任务的缺点，提出了用神经网络自适应滤波器来完成故障诊断的方法．神经网络有极快的运行速度，能很好地完成实时诊断任务．     

连铸小方坯的组织与性能研究

The hot cracking of the continuous casting bullit is connected with its macrostructure and mechanical property burnt. The macrostructure and the mechanical property of 0. 13 wt- %C continuous casting bullit was investigated. The results are as follows: 1) the classical representation of the casting bullit shows three distinct zones, a peripherial region of small equiaxed grains, a columnar zone, and a central equiaxed zone. The rapid increase of the under cooling layer thickness is the criterion of the transformation from the columnar zone to central equiaxed zone; 2) The hardness decreases with the reducing of the solidification speed; 3) The tensile strength decreases gradually from the peripherial equiaxed maximum principal strain zone to central equiaxed zone ,and increases with the drop of the temperature.     

Short alanine-based peptides may form 3(10)-helices and not alpha-helices in aqueous solution.

Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + 4; ref. 9) and the next most common peptide helix, the 3(10)-helix10 (i-->i + 3 hydrogen-bonding). To address this problem we have designed single and doubly spin-labelled analogues of alanine-based peptides in which the nitroxide spin label forms an unbranched side chain extending from the sulphur atom of a cysteine residue. Here we report the circular dichroism, Fourier-transform infrared and electron-spin resonance spectra of these peptides under helix-forming conditions. The infrared absorbance gives an amide I' band with a frequency that is substantially different from that observed for alpha-helices. The electron-spin resonance spectra of doubly labelled helices show that the ranking of distances between side chains, around a single turn (residues 4-8), is inconsistent with an alpha-helical structure. Our experiments suggest that the more likely peptide geometry is a 3(10)-helix.     

运动时血浆皮质醇变化的影响因素

本文综合了在运动时血清皮质醇浓度的变化不仅受运动形式，运动强度，运动持续时间，血浆ｐＨ，训练水平，缺氧，心理等多种因素的影响，并且各因素间的相互作用也是影响其变化的重要因素。     

一个关于抽象经济的均衡存在定理

在抽象经济的均衡存在定理中，一般都假设偏好对应具有开图像。用一个较弱的条件代替关于偏好对应的开图像假设，证明了均衡的存在性。所得结果是Ｙａｎｎｅｌｉｓ（１９８７）均衡存在定理的一个推广．     

数学规划模型的建模语言（FQL）

对数学规划模型的结构作了深入分析。从纵向揭示了数学规划模型自然、清晰的层次结构；横向又把复合模型分解成若干基本模型，而基本模型又可由决策用户十分熟悉的二维形式加以描述。在此基础上，给出了建模语言（ＦＱＬ）的语法和语义。它除了具有建模能力外，消除了代数形式的索引；更重要的是具有数据库查询和模型操作能力。     

大理市土地资源人口承载能力之研究

大理市人地矛盾十分尖锐，深入开展本市土地人口承载力的研究有着很重要的意义。本文在讨论土地承载力研究内容（包括三个部分：（１）土地承载力测算；（２）土地承载力分析；（３）对策与措施的制定）的基础上，测算了本市土地在不同投入水平下的人口承载量，进而分析了本市土地的人口承载状况，划分了不同时期（１９９０年、２０００年、２０３０年）不同投入水平下的土地承载力类型。最后，提出了缓解本市人地矛盾的主要对策和措施。